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Too Much White Rice, Pasta and Bread may Increase Chances of AMD

A study has revealed that high consumption of foods like white rice, pasta and bread, which have high-glycemic-index, increase the chances of developing age-related macular degeneration (AMD).

However, whole-wheat versions of rice, pasta and bread are examples of foods that have a low-glycemic-index. These foods are often considered higher quality carbohydrates because they are associated with a slower and less dramatic rise and fall of blood sugar.

AMD it is the leading cause of central vision loss (blindness) and in the United States.

Allen Taylor, PhD, director of the Laboratory for Nutrition and Vision Research at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University, and colleagues said that AMD link and vision loss may be connected to the quality of carbohydrates an individual consumes.

"Men and women who consumed diets with a higher glycemic index than average for their gender and age-group were at greater risk of developing advanced AMD. The severity of AMD increased with increasing dietary glycemic index," said Taylor said.

"Our results build upon findings from an earlier, smaller study in which we determined that consuming a diet with a high glycemic index, but not one with a high total amount of carbohydrate, increased the risk of developing early AMD," said first author Chung-Jung Chiu, DDS, PhD, scientist in the Laboratory for Nutrition and Vision Research at the HNRCA and an assistant professor at Tufts University School of Medicine.

In the current study, Taylor, Chiu, and colleagues analyzed data from 4,099 men and women participating in the nationwide Age-Related Eye Disease Study (AREDS). Detailed dietary histories were obtained at the start of the study when participants were 55 to 80 years of age and had varying degrees of AMD. The AREDS was designed to assess the effect of high-dose antioxidant vitamins and zinc on the p rogression of AMD and cataracts, two of the leading causes of vision loss in older adults.

"Although carbohydrate quality was not the main focus in the AREDS, we were fortunate that the investigators had collected the dietary carbohydrate information we needed to do our analyses," says Taylor, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts and the Tufts University School of Medicine. "Our findings suggest that 20 percent of the cases of advanced AMD might have been prevented if those individuals had consumed a diet with a glycemic index below the average for their age and gender," notes Taylor.

AMD typically occurs after middle age, although the events which cause it may begin earlier. A leading cause of irreversible blindness, AMD results from the gradual breakdown of light-sensitive cells in the central region of the eye's retina, called the macula. Although there is no effective therapy for AMD, dietary intervention may delay its progress. Identifying modifiable risk factors for AMD is becoming increasingly important as the population ages. As Taylor and colleagues point out, the number of people in the US with visually impairing AMD is expected to double and reach three million by 2020.

"Our results support our hypothesis," says Taylor, "that dietary glycemic index, which has been related to the risk of diabetes, is also associated with the risk and severity of AMD." Taylor speculates that carbohydrates that comprise a high-glycemic-index diet may provide eye tissue"It is possible that the type of damage produced by poor quality carbohydrates on eye tissue is similar in both diabetic eye disease and AMD."

Taylor and colleagues conclude that the risk for AMD may be diminished by improving dietary carbohydrate quality, as defined by dietary glycemic index. This may be achieved by relatively simple dietary alterations, such as replacing white bread with whole grain br ead.

"However, additional studies are needed before we can recommend dietary carbohydrate management as a prevention strategy for AMD," Taylor said.

The study is study published in the July issue of the American Journal of Clinical Nutrition.


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