Navigation Links
Toll-like Receptor (Tlr3) Attachment Leads To Lethal Encephalitis

Researchers have found that recognisation of West Nile Virus (WNV) by Toll-like// receptor (Tlr3) as the major factor which allows the virus to cross the blood-brain barrier (BBB) and cause lethal encephalitis.

WNV is a single stranded RNA (ssRNA) flavivirus with a life cycle that primarily involves birds and mosquitoes; however, humans and horses can become infected. In humans, infection is generally asymptomatic and if West Nile fever does develop then the illness is generally mild and self limiting. In elderly and immunocompromised individuals, however, WNV infection can progress to severe neurological disease. The molecular details oft he pathogenesis of severe disease are scarce. It is know that some TLRs can detect viral motifs such as ssRNA. In this study, researchers investigated the role of one of these TLRs , Tlr3, in the detection of WNV using a mouse model of WNV encephalitis.

Initial investigation showed that following intraperitonially challenge with a lethal dose of WNV, Tlr3 mice were more resistant to infection than wild type mice. Quantitative PCR assays showed that, following this challenge, the viral burden in the peripheral blood was increased in Tlr3 mice compared with wild type mice. Analysis blood cytokine levels showed increased levels of inflammatory cytokines in wild type, compared with Tlr3 mice early in infection. The results indicate that Tlr3 did have a role in WNV entry in to the brain. This was confirmed by comparing the permeability of BBB in wild type and Tlr3 mice following WNV infection or stimulation with the viral mimic poly (I:C), the permeability was increased in wild type mice but not in Tlr3 mice. A further insight into the pathogenesis of severe disease was provided by results suggesting that TNF-a receptor I signaling downstream of Tlr3 promotes WNV entry into the brain. Sporadic outbreaks of WNV infection of humans have become increasingly common over the past 5 years, particularly in North America and Europe. This new work identifying Tlr3 as the receptor allowing WNV to enter the brain can hopefully be exploited for the development of new therapeutics.

Source: Nature Microbiology.

Related Information on Mosquito borne infections in Medindia:

In India, malaria, filaria and dengue are the most prevalent diseases spread by mosquitoes. Over two million cases of malaria alone are reported. Even more astonishing is the fact that India spends 100 million dollars on malaria. In spite of spending so much, the diseases continue to explode from time to time. The reason is that these mosquitoes develop resistance to medicines and chemicals.

For more information:


Related medicine news :

1. Soluble IL-4 Receptor - A new boon for asthmatics
2. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
3. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
4. Researchers Identify Lung Failure Therapy Receptor
5. Effects Of Certain Food Related To Single Pain Receptors
6. Receptor for H.pylori Identified in Stomach
7. Functional Differences In Estrogen Receptor Could Be A Therapeutic Target
8. Schizophrenia Complicates With Altered Receptor Activity
9. Definite Connection Between Receptor Levels and Cocaine Abuse Reveals PET Imaging
10. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
11. Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax
Post Your Comments:

(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Inevitably when ... Many customers choose to buy during the Black Friday and Cyber Monday ... don’t need to search the Internet high and low to find the best massage ...
(Date:11/26/2015)... ... November 26, 2015 , ... Somu Sivaramakrishnan announced ... franchise owner, Somu now offers travelers, value and care based Travel Services, including ... sales, as well as, cabin upgrades and special amenities such as, shore excursions, ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical ... professionals and offered by healthcare staffing agency Aureus Medical Group . ... of October 2015 among those searching for healthcare jobs through the company’s website, ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare International, Inc., ... the 61st annual Employee Benefits Conference. The Employee Benefits Conference was hosted by ... through Wednesday, November 11th, 2015. The conference was held at the Hawaii Convention ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... consultation, has collaborated with Women’s Web – an online resource for Indian ... on mental and emotional well-being relationship, life balance, stress, professional development, and ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 /PRNewswire/ ... announced the addition of the "Global ... to their offering. --> ... "Global Brain Monitoring Devices Market 2015-2019" ... Research and Markets ( ) ...
(Date:11/25/2015)... Nov. 25, 2015  Amgen (NASDAQ: AMGN ) ... (BLA) with the United States ... a biosimilar candidate to Humira ® (adalimumab). Amgen ... submitted to the FDA and represents Amgen,s first BLA ... E. Harper , M.D., executive vice president of Research ...
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, a ... treatment outcomes for patients suffering from chronic pain, said ... a Temporary Restraining Order (TRO) enjoining Express Scripts from ... companies. --> --> ... of its legal options. --> ...
Breaking Medicine Technology: