Navigation Links
Tiny Sphere Of Nanoparticles Can Fight Cancer

Researchers have found in a preclinical trail, that siRNA packed as a tiny sphere can shrink ovarian cancer.//

Researchers from the University of Texas M. D. Anderson Cancer Centre had reported in the August 15th edition of Clinical Cancer Research, that siRNA that are wrapped up in a tiny sphere infiltrate deeply into ovarian cancer tumour cells, which could thereby oppress the troublesome protein and drastically reducing the size of tumours.

Anil Sood, M.D., associate professor in the Departments of Gynaecologic Oncology and Cancer Biology at M. D. Anderson, and the senior author explained that their experiment that was conducted on a mouse shows the effective delivery system for the short interfering RNA, (siRNA) in attacking the cancer cells.

Short interfering RNA is a great technology we can use to silence genes, shutting down production of harmful proteins, Sood says. 'It works well in the lab, but the question has been how to get it into tumours.' Short pieces of RNA don't make it to a tumour without being injected directly, and injection methods used in the lab are not practical for clinical use.

The research team took siRNA that targets a protein that helps ovarian cancer cells survive and spread and rolled it into a liposome -- a lipid ball so small that its dimensions are measured in nanometers (billionths of a meter).

Getting the siRNA inside tumour cells is important, Sood said, because the targeted protein, focal adhesion kinase (FAK), is inside the cell, rather than on the cell surface where most proteins targeted by cancer drugs are found. 'Targets like FAK, which are difficult to target with a drug, can be attacked with this liposomal siRNA approach, which penetrates deeply into the tumour,' Sood said.

Mice infected with three human ovarian cancer cell lines derived from women with advanced cancer were treated for 3-5 weeks. They received liposomes that contained either the FAK siRNA, a control siRNA, or were empty. Some mice received siRNA liposomes plus the chemotherapy docetaxel.

Mice receiving the FAK-silencing liposome had reductions in mean tumour weight ranging from 44 to 72 percent compared with mice in the control groups. Combining the FAK-silencing liposome with docetaxel boosted tumour weight reduction to the 94-98 percent range.

These results also held up in experiments with ovarian cancer cell lines resistant to docetaxel and to the chemotherapy drug cisplatin.

The FAK-silencing liposome and the liposome with chemotherapy also reduced the incidence of cancer by between 20 and 50 percent in all tested cancer lines.

In addition to its anti-tumour effect, the researchers found that the therapeutic liposome attacked the tumour's blood supply, especially when combined with chemotherapy. By inducing cell suicide (apoptosis) among blood vessel cells, the treatment steeply reduced the number of small blood vessels feeding the tumour, cut the percentage of proliferating tumour cells and increased cell suicide among cancer cells.

Sood and Professor of Molecular Therapeutics Gabriel Lopez-Berestein, M.D., an expert in liposomal therapeutics, cite at least two factors for the success of the anti-FAK liposome.

'This particle is so small, it has no problem getting through the tumour's vasculature and into the tumour,' Lopez-Bernstein says. The FAK-targeting liposome ranges between 65 and 125 nanometers in diameter. Blood vessels that serve tumours are more porous than normal blood vessels, with pores of 100 to 780 nanometers wide. Normal blood vessel pores are 2 nanometers or less in diameter.

Second, the liposome -- a commercially available version known as DOPC -- has no electrical charge. Its neutrality provides an advantage over positively or negatively charged liposome's when it comes to binding with and penetrating cells.

The next step for the FAK siRNA-DOPC liposome is toxicity testing. 'So far it appears to be very well-tolerated,' Sood says. 'We hope to develop this approach for clinical use in the future.'

In addition to ovarian cancer, FAK is over expressed in colon, breast, thyroid, and head and neck cancers.

Source: EurekAlert.
'"/>




Related medicine news :

1. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
2. Alzheimers Can Be Slowed Down By Gold Nanoparticles
3. Gold Nanoparticles Are Good Detectors Biological Toxins
4. Scientists To Study Effect Of Nanoparticles On Liver
5. Nanoparticles and Their Damage to Liver Cells
6. Effect of Nanoparticles on Liver
7. Use of Nanoparticles in Sunscreen under Scrutiny
8. Hybrid Nanoparticles for Multimodal Medical Imaging
9. Nanoparticles Used by Researchers to Attack Brain Tumours
10. Link Between Nanoparticles and Kidney Stones
11. UC Davis Creates New Nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: