( mechanisms of ribosomal protection and...)Tigecycline – New Generation Tetracycline With Broad Spectrum Antibacterial Activit,Health

mechanisms of ribosomal protection and active drug efflux. But, the new generation tetracycline - Tigecycline is not affected by either of these mechanisms.

Clinical studies and FDA approval: Two clinical studies proving the active effect of Tigecycline as lead to FDA approval of Tigecycline for treatment of bacterial infections.

Study I: Tigecycline was tested on patients with complicated skin and skin-structure infections.

The study was performed in 800 adult patients. Tigecycline was given in a concentration of 100 mg intravenous initial dose followed by 50 mg every 12 hours which was compared with vancomycin 1 g intravenously every 12 hours/aztreonam 2 g intravenously every 12 hours for 5–14 days.

Study II: Tigecycline was tested in patients with complicated intra-abdominal infections

The study was performed in more than 1,000 adult patients. Tigecycline was given at a dosage of 100 mg intravenous initial dose followed by 50 mg every 12 hours which was compared with imipenem/cilastatin 500 mg intravenously every 6 hours for 5–14 days.

Tigecycline has great promise as a new therapeutic agent against important pathogens and is highly active against both nosocomial and Methicillin Resistant S. aureus strains (MRSA), vancomycin resistant E. faecium and penicillin resistant strains of S. pneumoniae. Though, Tigecycline's structure is similar to that of the tetracyclines but additional structural elements increase its potency and impede the mechanisms of bacterial resistance associated with the tetracyclines.

Source: Nature Reviews Drug Discovery
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