Navigation Links
Tiagabine Enhances Sleep Maintenance In Insomnia Patients

Recent research indicates that tiagabine, a selective ?-aminobutyric acid (GABA) reuptake inhibitor, has positive effect on sleep and next-morning alertness and performance in adult patients with primary insomnia.//

Primary insomnia is characterized by difficulty initiating or maintaining sleep and/or nonrestorative sleep, which causes clinically significant distress or impairment in important areas of waking function.

The authors, writing in the journal Sleep Medicine (available online 2 November 2005) assert that since GABA is a major inhibitory neurotransmitter in the central nervous system and tiagabine increases synaptic availability of GABA, hypnotic properties would seem a likely dose-related effect.

The researchers evaluated the effect of tiagabine administered before bedtime at doses from 4 to 16 mg on sleep and next-morning alertness and psychomotor performance in adult patients with primary insomnia.

Fifty-eight middle-aged patients were randomized for the study. Results showed a significant dose-dependent increase in slow wave sleep percentage with all tiagabine doses, a trend toward a dose-dependent increase in total sleep time, and no effect on latency to persistent sleep.

The authors conclude that tiagabine increased slow wave sleep and reduced wake after sleep onset in a dose-dependent manner. Tiagabine dosages up to 8 mg did not compromise next-morning alertness and psychomotor performance in adult patients with primary insomnia. Further investigation of tiagabine doses up to 8 mg is warranted.

The authors suggest that additional studies with tiagabine are warranted to further investigate tiagabine's clinical effects in patients with insomnia. Also of interest are the potential differences associated with increases in slow wave sleep mediated by different neurotransmitter systems.


Page: 1

Related medicine news :

1. Animal Fat Enhances Risk Of Stomach
2. Simulated Heart Tissue Enhances Understanding of Arrhythmias And Defibrillator Failure
3. Glivec Enhances Survival Rates In Leukemia
4. Study Claims That Chemo Before And After Surgery Enhances Survival Rates
5. Common Virus Enhances Cancer-Fighting Ability of Standard Chemotherapy Drugs
6. Haryana Enhances Nutritional Support for Women, Children
7. Loop Incision Treatment Enhances Premature Delivery Risk
8. Sleep apnoea increases post-operative risks
9. Sleep, snoring....stroke
10. Sleeping sickness - a silent killer
11. Deep Sleep Doesnt Increase Memory
Post Your Comments:

(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... ... 12, 2017 , ... The American College of Medical Informatics (ACMI) will present ... the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... Collen, a pioneer in the field of medical informatics, this prestigious award is presented ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
(Date:9/13/2017)... OrthoAtlanta has been named the official orthopedic and sports ... the 2018 College Football Playoff (CFP) National Championship to be ... Atlanta, Georgia . OrthoAtlanta is proud to ... in many activities leading up to, and including the national ... OrthoAtlanta ...
Breaking Medicine Technology: