Navigation Links
Tiagabine Enhances Sleep Maintenance In Insomnia Patients

Recent research indicates that tiagabine, a selective ?-aminobutyric acid (GABA) reuptake inhibitor, has positive effect on sleep and next-morning alertness and performance in adult patients with primary insomnia.//

Primary insomnia is characterized by difficulty initiating or maintaining sleep and/or nonrestorative sleep, which causes clinically significant distress or impairment in important areas of waking function.

The authors, writing in the journal Sleep Medicine (available online 2 November 2005) assert that since GABA is a major inhibitory neurotransmitter in the central nervous system and tiagabine increases synaptic availability of GABA, hypnotic properties would seem a likely dose-related effect.

The researchers evaluated the effect of tiagabine administered before bedtime at doses from 4 to 16 mg on sleep and next-morning alertness and psychomotor performance in adult patients with primary insomnia.

Fifty-eight middle-aged patients were randomized for the study. Results showed a significant dose-dependent increase in slow wave sleep percentage with all tiagabine doses, a trend toward a dose-dependent increase in total sleep time, and no effect on latency to persistent sleep.

The authors conclude that tiagabine increased slow wave sleep and reduced wake after sleep onset in a dose-dependent manner. Tiagabine dosages up to 8 mg did not compromise next-morning alertness and psychomotor performance in adult patients with primary insomnia. Further investigation of tiagabine doses up to 8 mg is warranted.

The authors suggest that additional studies with tiagabine are warranted to further investigate tiagabine's clinical effects in patients with insomnia. Also of interest are the potential differences associated with increases in slow wave sleep mediated by different neurotransmitter systems.


'"/>




Page: 1

Related medicine news :

1. Animal Fat Enhances Risk Of Stomach
2. Simulated Heart Tissue Enhances Understanding of Arrhythmias And Defibrillator Failure
3. Glivec Enhances Survival Rates In Leukemia
4. Study Claims That Chemo Before And After Surgery Enhances Survival Rates
5. Common Virus Enhances Cancer-Fighting Ability of Standard Chemotherapy Drugs
6. Haryana Enhances Nutritional Support for Women, Children
7. Loop Incision Treatment Enhances Premature Delivery Risk
8. Sleep apnoea increases post-operative risks
9. Sleep, snoring....stroke
10. Sleeping sickness - a silent killer
11. Deep Sleep Doesnt Increase Memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... 12, 2017 , ... First Healthcare Compliance (FHC), an industry ... a range of technology and learning solutions at the 68th Annual American Healthcare ... be held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned ... Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness ... on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... YORK , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a ... today announced that its MyDario product is expected to appear on The ... when The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz ... The ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
(Date:9/19/2017)... -- HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy ... team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D ...
Breaking Medicine Technology: