Navigation Links
Three Gene Variants Could Hold Key for HIV Vaccine: Study

Three gene variants in the DNA of 486 AIDS patients appear to play a role in containing and slowing the HIV virus, according to research published Thursday.

The researchers hope their finding will lead to a vaccine that would boost the protective effects of one or more of these genes, and help the body's own immune system overcome an infection.

One gene variant looks specially promising, the scientists said in a study to appear in the Friday edition of the journal Science.

"These results not only approximately double our understanding of the factors that influence variation amongst individuals in how they control HIV-1, but also point toward new mechanisms of control," said David Goldstein, of Duke's Institute for Genome Sciences and Policy at North Carolina's Duke University and chief author of the study.

The international team of geneticists worked for 18 months in carefully selecting patients and using the latest in genome-wide screening technology to discover the three genes.

The research found that some patients with specific gene variants in key immune system cells appear to be much better controlling the proliferation of the AIDS virus after infection.

"As we expand the number of patients in future studies conducted by CHAVI (Center for HIV/AIDS Vaccine Immunology) researchers, we aim to discover even more polymorphisms that could provide additional clues how some patients are better able to control the virus than others," Goldstein said.

"This should ultimately lead to novel targets for vaccines, the primary goal of CHAVI," a seven-year project launched in 2005 by the National Institute of Allergy and Infectious Diseases (NIH).

Two of the newly discovered gene variants were found in genes controlling the human leukocyte antigen (HLA) system, which plays a "major role" in the immune system by identifying foreign invaders and "tagging" them for des truction.

Two of the HLA genes, known as HLA-A and B, are turned off by the HIV virus when it enters the body, which keeps the immune system from recognizing the virus as foreign.

However, the HLA-C gene is apparently not turned off by the AIDS virus, suggesting that for some individuals at least HLA-C is involved in controlling the HIV virus, the researchers said.

The HLA-C gene may represent an Achilles heel of HIV, according to Goldstein.

A vaccine could be designed to elicit an HLA-C mediated response that the HIV virus might be unable to defuse, the expert added.


'"/>




Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. Nobel Prize for Medicine shared by Three scientists
3. Three Tropical Parasites Genetic Code Unravelled
4. The Future Pattern Of Weight Gain Is Laid As Early As Three Years Of Age
5. Smoking Increases The Risk Of Heart Disease By Three Times
6. Three Sisters Have One Baby and Make History
7. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
8. Three More Bird Flu Cases Reported By China
9. Three meals daily Keeps Keralas elderly Healthy
10. Three dimensional structure of apolipoprotein revealed
11. Delhi Witnessed 34 Meningitis Deaths In Three Months
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... The book, “Computers Should Just Work!”, provides a ... ask your IT consultant before signing a contract and how to spot an incompetent ... companies relying heavily on e-mail and technology, it’s more important than ever to make ...
(Date:2/10/2016)... ... February 10, 2016 , ... President Obama’s ... Advantage organizations to deliver medical services via telehealth, estimated to generate more than ... for such language for many years. Although there is more to be ...
(Date:2/10/2016)... ... 10, 2016 , ... Early this week, Team Iconic at J. Walter Thompson ... as the first global confectionery brand sourced from 100% sustainable cocoa. , The Nestlé ... their product, through activities that focus on better farming, better lives and better cocoa. ...
(Date:2/10/2016)... ... 10, 2016 , ... Western University of Health Sciences and ... developmentally disabled in the Coachella Valley. , The two entities, through an expanded ... Highway 111, Suite 100-B, in Rancho Mirage, California. The new site has 11 ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... (VRI) within Healthcare, recently partnered with Heart City Health Center to ... nearly 23 years, Heart City Health Center has provided the Elkhart community with ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 11, 2016 ... the "Molecular Diagnostics Reports Bundle" ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ... report to their offering. --> ... announced the addition of the "Molecular ...
(Date:2/10/2016)... SUNNYVALE, Calif. , Feb. 10, 2016 /PRNewswire/ ... Warren Kocmond , formerly Executive Vice President ... the position of President and Chief Operating Officer.  ... been expanded, and now include Global Commercial Operations ... and Customer Service.  Mr. Kocmond will continue to ...
(Date:2/10/2016)... , February 10, 2016 --> --> ... Japan .  --> Japan .  --> A ... With submission, Shire continues to strengthen ... With submission, Shire continues to strengthen its presence ... submission, Shire continues to strengthen its presence ...
Breaking Medicine Technology: