Navigation Links
Threat posed by highly resistant strains of TB

An article published online this week in The Lancet warns that tuberculosis (TB) programs and HIV programs may face a threat from tuberculosis strains //that are resistant to both first-line and second-line drugs.

The study conducted by a team of researchers from the United States and South Africa reveals that highly resistant strains of TB that are responsible for increased death rates in HIV patients are widespread in a rural area of KwaZulu Natal, South Africa. TB claims nearly 1.7 million lives every year and is a major cause of death in HIV-infected patients in low-income countries.

In the study, presented by Dr. Neel Gandhi assistant professor of medicine at the Albert Einstein College of Medicine of Yeshiva University, the researchers tested patients with suspected tuberculosis for MDR and XDR strains. They found that of 1,539 patients, 221 had MDR tuberculosis, and 53 of these had XDR tuberculosis. The prevalence rates in a group of 475 patients with confirmed tuberculosis were 39% for MDR and 6% for XDR tuberculosis—higher rates than previously reported in the area. All patients with XDR disease who were tested for HIV were co-infected with the virus, and all but one died.

(Dr. Gandhi conducted this research while he completing fellowships at Yale University School of Medicine and Emory University. He joined the Einstein faculty in August 2006.) Further complicating the problem posed by multidrug-resistance is the fact that the epidemics of tuberculosis and HIV in South Africa are closely linked. Risk of tuberculosis disease is greatly increased in people with HIV infection, and multidrug-resistant (MDR) tuberculosis is emerging as a major cause of death in these patients. The term extensively drug-resistant (XDR) tuberculosis has recently been used to describe strains that are resistant to second-line drugs—i.e., drugs that are used if the recommended first drug treatment regimen fails.

Investigation of the pa tients’ histories and the genetic makeup of the infecting bacteria suggested that transmission of XDR strains had occurred recently, that transmission between individuals had occurred, and that some patients had been infected while in hospital. The researchers say that these findings are worrying, since hospitals in low-income countries have limited infection-control facilities and a high proportion of susceptible HIV-infected patients. They recommend action to tackle the problem of resistant strains that could jeopardise attempts to control tuberculosis and prevent mortality in HIV patients.

In addition to Dr. Gandhi, other researchers involved in the collaborative project were Dr. Gerald Friedland, director of the AIDS Program at Yale University; Dr. Tony Moll, of the Church of Scotland Hospital in Tugela Ferry, South Africa; and Drs. Willem Sturm, Robert Pawinksi and Umesh Lalloo, of the Nelson R. Mandela School of Medicine, in Durban, South Africa.

Source-Eurekalert
GT
'"/>




Related medicine news :

1. Is Smallpox Threat Real ?
2. WHO To Support Public Health Threats
3. Food May Trigger Life-Threatening Asthma
4. New Virus : A Threat In the Future?
5. Tsunami Survivors Face Pneumonia Threat
6. The Use Of Invasive Treatment For Life Threatening Heart Conditions Questioned
7. Baking Soda Treatment for Life-Threatening Asthma
8. Ethiopian Children Face Threat From Malnutrition
9. Pigs Population A Major Threat To Encephalitis Ravaged UP
10. Winter Premature Babies Face Threat From Lung Disease
11. Alcohol Consumption A Threat To Colorectal Tumours
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... 2017 , ... Only two months after the official release of The Private ... (France), XO Private has initiated a second print-run of its lavish luxury travel coffee ... across when open, weighs in at more than six kilos, retails at EUR 1,000 ...
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis of ... of Pittsburgh points to eight genes that may explain why susceptibility to one of ... results of a study published today in the journal npj Schizophrenia. , “There ...
(Date:2/24/2017)... ... , ... The Smart Machine Age is here, and it’s disrupting everything. Not ... all jobs in the United States may be taken over by technology in the ... know-it-all who steamrolls over colleagues is drawing to a close. Success will belong to ...
(Date:2/24/2017)... ... February 24, 2017 , ... With millions of Americans and ... that we all are aware of our options and are empowered with strength ... the launch of its newest edition of "Vision and Hearing" in USA Today, ...
(Date:2/24/2017)... Melbourne, Australia (PRWEB) , ... February 24, 2017 , ... ... Press AU) offers Erik Schanssema ’s true account of his paramedic experiences. Schanssema ... post-traumatic stress disorder and his attempts to overcome them. , Schanssema, initially unsure ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)...  In conjunction with DURECT Corporation,s (Nasdaq: ... you are invited to listen to a conference call ... Tuesday, March 14, 2017 at 4:30 pm Eastern Time ... webcast of the presentation will be available by accessing ... Relations."  If you are unable to participate during the ...
(Date:2/24/2017)... Report analyzes the worldwide markets for Endodontic Supplies in US$ ... Canada , Japan , ... Latin America , and Rest of World. ... through 2022. Also, a six-year historic analysis is provided for ... and secondary research. Company profiles are primarily based on public ...
(Date:2/24/2017)... 23, 2017  This report analyzes the worldwide markets ... Products: Intermediates, Analytical, and Others. The ... Pharmaceuticals, and Agrochemicals. The report provides separate comprehensive analytics ... Europe , and Rest of World. Annual ... through 2022. Also, a six-year historic analysis is provided ...
Breaking Medicine Technology: