Navigation Links
There is light at the end of the blind tunnel: prosthetic retinal cells offer hope!

People with inherited retinal degeneration have hope of vision since researchers have engineered cells in the eye to be light sensitive that were not before.//

Zhuo-Hua Pan of Wayne State University School of Medicine and colleagues have engineered this technology using a harmless virus, they introduced a gene for a light-sensitive protein into "inner retinal neurons" in a strain of mice with photoreceptor deficiency that resembles the defect in such inherited human disorders as retinitis pigmentosa. The light-sensitive protein they used, called channelrhodopsin-2 (ChR2), is found in green algae.

The introduced protein rendered the retinal neurons sensitive to light.

Writing a review of this paper from Neuron journal John Flannery and Kenneth Greenberg wrote,” With this strategy, the investigators have made a paradigm shift in the field and opened the possibility of genetically modifying the surviving retinal interneurons to function as a replacement light-sensing receptor. This publication is clearly a significant first step into this new field of re-engineering retinal interneurons as genetically modified 'prosthetic' cells.”

Still the researchers said that they have not yet determined whether the light signals reaching the visual cortex could be interpreted as vision and also the algal protein is less sensitive to light than is the normal light-detecting protein in the eye. Therefore they stress more work in this area.

The researchers say, "The remodeling of inner retinal neurons triggered by photoreceptor degeneration has raised some concerns for the retinal-based rescue strategy after the death of photoreceptors. However, retinal degenerative diseases are heterogeneous as to the time course of the degeneration, survival cell types, and, possibly, their functional state. Therefore, further studies are required to evaluate what types of retinal degenerative diseases and/or what disease stages are suitable for this potential treatment strategy. An important advantage of the strategy sought in this study is that it does not involve the introduction of tissues or devices into the retina and, therefore, may largely avoid the complications of immune reactions and biocompability. In addition, it could potentially achieve high spatial resolution for the restored 'vision' because the approach targets the cellular level. Thus, the expression of microbial-type channelrhodopsins, such as ChR2, in surviving retinal neurons may be another potential strategy for the treatment of complete blindness caused by rod and cone degeneration.”

'"/>




Related medicine news :

1. Could There Be A Link Between Famine and Breast Cancer ?
2. Can There Be A Diabetes Type III?
3. Diabetic Amputation May Reduce If Free Screenings Are There
4. Hospital Says There Is Time but Baby Decides Otherwise
5. WHO’s asking :Is There Light At The End Of The Tunnel In Tajikistan
6. Is There A Strong Link Between Fluoride In Tap Water And Bone Cancer?
7. Is There a Connection between Hearing loss and High-speed Dental Tools?
8. Is There Any Clinical Benefit to Staying on a Failing Regimen?
9. Doctors operate upon patients in candlelight- latest from the quake scene
10. “Don’t fear long haul flights!” Vascular surgeon tells travelrs
11. Hazards of sunlight
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: