Navigation Links
The potent anti-leukemia activity of Berbamine

Chronic myeloid leukemia (CML) is a pluripotent hematopoietic stem cell disorder characterized by accumulation of mature and immature granulocytes in peripheral blood and bone marrow due to uncontrolled growth // and resistance to apoptosis. The dysregulated activity of the bcr/abl oncoprotein tyrosine kinase, which is encoded by the bcr?abl fusion gene, has been shown to be responsible for the malignant phenotypes.

Gleevec, which is an inhibitor of the bcr/abl tyrosine kinase, has been a remarkable success for the treatment of CML. However, a significant proportion of patients chronically treated with Gleevec develop resistance. Thus, new approaches that override the resistance are crucial to the development of curative therapies for CML.

A recent study, to be published in Leukemia Research (available online 14 July 2005) describes the anti-leukemia activity of a natural small molecular compound, berbamine from plant Berberis amurensis that can selectively induce cell death of both Gleevec-sensitive and -resistant Ph+ CML cells.

Importantly, the results in this study show that berbamine is also active against Gleevec-resistant leukemia cells. It is of interest to note that berbamine down-regulates p210 bcr/abl oncoprotein of Ph+ leukemia cells, suggesting that this compound have different anti-leukemia mechanism from that of Gleevec.

The results indicate that up to 76% of leukemia cells were apoptotic cells after treatment with berbamine at concentration of 16 ì g/ml for 48 h, suggesting that the growth inhibition of berbamine for leukemia cells is caused by apoptosis of leukemia cells. Results also suggest that berbamine-induced apoptosis is mediated via caspase-3-dependent pathway.

Another important feature of berbamine is the very desirable safety that is not often seen in conventional chemotherapeutic agents. In addition, berbamine is widely used to improve normal hematopoiesis and immune function of c ancer patients in China.

The authors conclude that berbamine might be a novel bcr/abl inhibitor with potent anti-leukemia activity, and that the potency of berbamine against both Gleevec-sensitive and -resistant Ph+ leukemia cells, and its distinct mechanism of anti-leukemia activity warrant further investigation of berbamine for the treatment of CML

Related medicine news :

1. Hepatitis E virus made impotent
2. Unwed mothers find it difficult to attract potential life partner
3. Unpasteurised juices found to be potential health hazards
4. The many facets of milk and its health potential
5. Artificial sweetener, Aspartame, may be the potential cause of lymphoma, leukaemia
6. Alcohol a potential carcinogen: knocking on the door: pay heed!
7. A potent causative agent of dental flourosis: Fluoride
8. Quebec arming itself to combat a potential influenza pandemic
9. Smoking Is a Vital Cause among Impotent Men
10. Pluripotent ESC, To Serve As an Effective Therapy for Many Diseases
11. Estrogen also a potential neurotransmitter
Post Your Comments:

(Date:11/27/2015)... ... 2015 , ... "When I was traveling, I was very ... "Many people catch diseases simply from sitting on such dirty toilet seats. I ... germs." , He developed the patent-pending QUDRATECS to eliminate the need to sit ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that ... ). More than 3.7 billion people under the age of 50 – or 67% ... WHO's first global estimates of HSV-1 infection . , "The data shocks us highly!" ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you stop ... not only fulfilling the needs of advisers and clients but going above and ... providing top-tier customer service. However, there's always room for improvement, which is why ...
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap and ... Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health System’s Santa Rosa ... Sepsis conditions present in similar ways and require time-critical intervention to avoid large area ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, ... choose to buy during the Black Friday and Cyber Monday massage chair sales ... search the Internet high and low to find the best massage chair deals, they ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- Research and Markets ( ) has ... Horizons and Growth Strategies in the Japanese Therapeutic ... Forecasts, Competitive Intelligence, Emerging Opportunities" report to ... --> This new 247-page report provides ... monitoring market, including emerging tests, technologies, instrumentation, sales ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda SyMRI ... (MR-bilder) för patienter med multipel skleros ... forskningsavtal med SyntheticMR AB för att kunna ... på sjukhuset. Med SyMRI kan man generera ...
Breaking Medicine Technology: