Navigation Links
The potent anti-leukemia activity of Berbamine

Chronic myeloid leukemia (CML) is a pluripotent hematopoietic stem cell disorder characterized by accumulation of mature and immature granulocytes in peripheral blood and bone marrow due to uncontrolled growth // and resistance to apoptosis. The dysregulated activity of the bcr/abl oncoprotein tyrosine kinase, which is encoded by the bcr?abl fusion gene, has been shown to be responsible for the malignant phenotypes.

Gleevec, which is an inhibitor of the bcr/abl tyrosine kinase, has been a remarkable success for the treatment of CML. However, a significant proportion of patients chronically treated with Gleevec develop resistance. Thus, new approaches that override the resistance are crucial to the development of curative therapies for CML.

A recent study, to be published in Leukemia Research (available online 14 July 2005) describes the anti-leukemia activity of a natural small molecular compound, berbamine from plant Berberis amurensis that can selectively induce cell death of both Gleevec-sensitive and -resistant Ph+ CML cells.

Importantly, the results in this study show that berbamine is also active against Gleevec-resistant leukemia cells. It is of interest to note that berbamine down-regulates p210 bcr/abl oncoprotein of Ph+ leukemia cells, suggesting that this compound have different anti-leukemia mechanism from that of Gleevec.

The results indicate that up to 76% of leukemia cells were apoptotic cells after treatment with berbamine at concentration of 16 ì g/ml for 48 h, suggesting that the growth inhibition of berbamine for leukemia cells is caused by apoptosis of leukemia cells. Results also suggest that berbamine-induced apoptosis is mediated via caspase-3-dependent pathway.

Another important feature of berbamine is the very desirable safety that is not often seen in conventional chemotherapeutic agents. In addition, berbamine is widely used to improve normal hematopoiesis and immune function of c ancer patients in China.

The authors conclude that berbamine might be a novel bcr/abl inhibitor with potent anti-leukemia activity, and that the potency of berbamine against both Gleevec-sensitive and -resistant Ph+ leukemia cells, and its distinct mechanism of anti-leukemia activity warrant further investigation of berbamine for the treatment of CML
'"/>




Related medicine news :

1. Hepatitis E virus made impotent
2. Unwed mothers find it difficult to attract potential life partner
3. Unpasteurised juices found to be potential health hazards
4. The many facets of milk and its health potential
5. Artificial sweetener, Aspartame, may be the potential cause of lymphoma, leukaemia
6. Alcohol a potential carcinogen: knocking on the door: pay heed!
7. A potent causative agent of dental flourosis: Fluoride
8. Quebec arming itself to combat a potential influenza pandemic
9. Smoking Is a Vital Cause among Impotent Men
10. Pluripotent ESC, To Serve As an Effective Therapy for Many Diseases
11. Estrogen also a potential neurotransmitter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... Orion, Michigan (PRWEB) , ... ... ... a disease affecting the female reproductive tract in which the endometrial lining ... pelvic structures causing inflammation and pain. Patients experiencing painful intercourse, painful periods, ...
(Date:5/24/2017)... ... 24, 2017 , ... Rob Lowe is a sought after actor, and also ... brings the public important topics from all aspects of life, and a new segment ... surrounding feet and ankles. , Podiatry is essential to people’s overall well-being, and if ...
(Date:5/23/2017)... ... May 23, 2017 , ... MDLand ... Integration company, announced today that its iClinic V12.2 solution has achieved approval from ... NCQA recently introduced PCMH 2017 standards which emphasize team-based care with a significant ...
(Date:5/23/2017)... , ... May 23, 2017 , ... New England Journal ... Crisis Worthy of a Policy Response”, -The Rory Staunton Foundation Calls on Health & ... for the Prevention of Sepsis ( http://www.rorystauntonfoundation.org ) today reported on a new study ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months of ... call for diligence, asking homeowners to scout for any open water sources that can ... the annoying buzz of mosquitos is the buzz associated with potential infections stemming from ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... Clarius Mobile Health, a digital healthcare ... this week at the American Congress of Obstetricians ... San Diego, CA from May ... perfect tool for clinicians to easily confirm pregnancy, ... pregnancy-related complications like ectopic pregnancy and placenta previa," ...
(Date:5/4/2017)... , May 4, 2017   BioLife Solutions ... developer, manufacturer and marketer of proprietary clinical grade ... ("BioLife" or the "Company"), today announced that the Company,s ... market close on Thursday, May 11, 2017, and that ... webcast at 1:30 p.m. PT that afternoon. Management will ...
(Date:5/3/2017)... , May 3, 2017  West Pharmaceutical ... innovative solutions for injectable drug administration, announced today ... Affairs and Technical Services, and Diane Paskiet ... and offering presentations focused on West,s expertise in ... products, as well as providing commentary on updated ...
Breaking Medicine Technology: