Navigation Links
The 'bitter' proteins

A new study says that proteins associated with Alzheimer’s may worsen the symptoms of Parkinson’s disease and vice versa, and understanding this interaction could improve treatments for these conditions, say US researchers. Although both diseases are distinct neurological disorders, up to one-third of Alzheimer’s patients develop Parkinson’s and some Parkinson’s patients develop signs of Alzheimer’s.//

To research a possible link between the two diseases, neurology experts from the University of California and Gladstone developed strains of transgenic mice that produce two human proteins – human amyloid precursor protein (hAPP) and human alpha-synuclein (hSYN).Of the two proteins, hAPP is linked with Alzheimer’s and hSYN with Parkinson’s; and mice that produce one of these proteins develop the symptoms of the associated disease.

The researchers discovered that both Alzheimer’s and Parkinson’s symptoms were worse in the mice that had both conditions than in the mice that had just one of the diseases. Alzheimer-like symptoms – degeneration of particular classes of brain cells and impaired ability to learn – were enhanced by the production of hSYN (the protein associated with Parkinson’s), said the team.

They also found that Abeta – a metabolite of the Alzheimer’s protein hAPP – increased the build-up of hSYN in brain cells. This, said the researchers, shows a possible mechanism for the synergistic effects of one of the proteins on the other.The scientists suggest the interaction between the hAPP and hSYN means that drugs blocking these proteins could have broader benefits than previously thought. The study also helps explain the underlying mechanisms that destroy the cognitive and motor functions of Alzheimer’s patients who go on to develop Parkinson’s, they said.


'"/>




Page: 1

Related medicine news :

1. Special proteins to fight TB identified
2. Special proteins to fight TB identified
3. Obese children may have abnormalities of lipoproteins
4. Mix and match of proteins may have a significant role in immunity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
(Date:10/12/2017)... ... , ... On Saturday, October 21, the Health & Wellness Center at Florida ... money for the American Heart Association Heart Walk. Teams of up to 10 people ... keep their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first interactive health literacy software tool, and the Cancer Patient Education Network (CPEN), ... patient education, today announce a new strategic alliance. , As CPEN’s strategic ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
Breaking Medicine Technology: