( When everyone thought that Hematopoieti...)The Other Side of Hematopoietic Stem Cell Transplant,Health

When everyone thought that Hematopoietic stem cell transplant could help in fighting cancer,// a recent study issued an alarming finding. According to this, if HSCT recipients are more prone to a relapse of caner in the following cases:
a. if they were older at the time of tranplant b. if the stem cells are from a female donor.

This second cancer could occur within ten years from the time of the original transplant. This is more pronounced in them than the general public. In the event of the recipient being in the older age group i.e, older than forty years, the risk quadruples.

Myeloablative, allogeneic HSCT is an effective standard therapy for specific life-threatening diseases, such as leukemia or myelodysplastic syndrome, for which blood cell lineages (which originate principally in the bone marrow and circulate in the blood) are abnormal. Destroying the patient's own unhealthy stem cells in the bone marrow and replacing them with a compatible donor's stem cells offers the chance of cure for a disease that otherwise has a high mortality rate with non-transplant therapies. While the procedure can be lifesaving, it is associated with serious short-term adverse effects, such as mucostitis, infections, and liver vascular obstruction as well as the potential long-term complication of developing of a second, usually solid cancer.

To estimate the risk and identify risk factors associated with this outcome, Genevieve Gallagher, M.D. and Donna L. Forrest, M.D. of the BC Cancer Agency and the University of British Columbia, retrospectively reviewed the medical records of 926 patients treated with myeloablative stem cell transplants over an 18-year period.

They found that at their institution the 10-year incidence of second cancers in these patients was 3.1 percent. When nonmelanoma skin cancer and carcinoma in situ of the cervix were excluded, incidence was 2.3 percent. That risk was 1.85 times that of the general pop
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