Navigation Links
The Other Side of Hematopoietic Stem Cell Transplant

When everyone thought that Hematopoietic stem cell transplant could help in fighting cancer,// a recent study issued an alarming finding. According to this, if HSCT recipients are more prone to a relapse of caner in the following cases:
a. if they were older at the time of tranplant b. if the stem cells are from a female donor.

This second cancer could occur within ten years from the time of the original transplant. This is more pronounced in them than the general public. In the event of the recipient being in the older age group i.e, older than forty years, the risk quadruples.

Myeloablative, allogeneic HSCT is an effective standard therapy for specific life-threatening diseases, such as leukemia or myelodysplastic syndrome, for which blood cell lineages (which originate principally in the bone marrow and circulate in the blood) are abnormal. Destroying the patient's own unhealthy stem cells in the bone marrow and replacing them with a compatible donor's stem cells offers the chance of cure for a disease that otherwise has a high mortality rate with non-transplant therapies. While the procedure can be lifesaving, it is associated with serious short-term adverse effects, such as mucostitis, infections, and liver vascular obstruction as well as the potential long-term complication of developing of a second, usually solid cancer.

To estimate the risk and identify risk factors associated with this outcome, Genevieve Gallagher, M.D. and Donna L. Forrest, M.D. of the BC Cancer Agency and the University of British Columbia, retrospectively reviewed the medical records of 926 patients treated with myeloablative stem cell transplants over an 18-year period.

They found that at their institution the 10-year incidence of second cancers in these patients was 3.1 percent. When nonmelanoma skin cancer and carcinoma in situ of the cervix were excluded, incidence was 2.3 percent. That risk was 1.85 times that of the general pop ulation. The median time to diagnosis was almost 7 years after transplant. The most commonly reported second cancers were cancers of the skin (basal and squamous cell), lung, oral cavity, and colon.

Furthermore, data analysis showed that the risk more than tripled for patients who received their transplant when they were over 40 years of age. The study also identified a new risk factor: patients who received stem cells from a female donor had almost quadrupled the risk of a second solid cancer, a risk that further increased when the patient was male. "This observation has not been previously reported in the literature and the explanation for this finding is uncertain," say the authors.

"Since the risk of developing a solid neoplasm post-allogeneic transplantation continues to increase with time," suggest the authors, "extended follow-up will be needed to more fully assess the incidence and risk factors for their development."

Source-Eurekalert
'"/>




Related medicine news :

1. Twins Less Prone to Suicide Than Others
2. Sleep Disorders Could Indicate Other Medical Problems
3. Features Of The Brain Affect Asthma And Other Stress Related Disorders
4. Smokers Avoid Dental Care More Than Others
5. Brain Patterns In Amusia May Be Related To Other Disorders
6. Genetic Eye Disorder Can Have Other Implications
7. Some See A Hopeless End, While Others See An Endless Hope
8. Dead Palestinian Boy Saves Lives Of Six Others
9. Avastin, anti-Cancer Drug leads to Blindness and Other Complications
10. Hamsters Shows How Our Brains May Recognize Other Individuals
11. Anticancer Properties of Vitamin D Could Be Separated From Other Functions
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... Finally, a bruise cream that really works. Originally ... incorporated into the post-surgical treatment plans of a variety of other procedures including, but ... very effective for bruising and causes a rapid resolution of bruising and inflammatory changes ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Markarian, DDS, are co-chairs for the Illinois State Dental Society (ISDS) Foundation’s Mission ... at the Gateway Convention Center in Collinsville. , They expect to ...
(Date:6/24/2016)... ... 24, 2016 , ... SpiritQuest Sedona Retreats, located in Arizona has re-located to ... vortex sites: Cathedral Rock, Airport Mesa, and Boynton Canyon. The new retreat center ... as well as the Sedona Rouge, both popular accommodations for SpiritQuest clients. The ...
(Date:6/23/2016)... Colo., USA (PRWEB) , ... June 23, 2016 ... ... and Sanquin Blood Supply Foundation, a not-for-profit organization responsible for clinical transfusion research ... of patient enrollment for the Pathogen Reduction Evaluation and Predictive Analytical Rating Score ...
(Date:6/23/2016)... ... June 23, 2016 , ... vcfo, a consulting firm that ... to announce the promotion of Mike Mackey to Regional Vice President of Southeast ... was responsible for managing client projects and overseeing vcfo financial consultants in the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
Breaking Medicine Technology: