Navigation Links
The 'Mad Cow' Disease And Protein

The PrPC is a normal physiological protein, especially present in the central nervous system, including// that of the human, with functions that are little known as yet. Altered prionic proteins, pathogens, infectants, i.e. prions, are responsible for spongiform encephalopathies, amongst these being bovine spongiform encephalopathy (BSE or mad cow disease). In order to operate, prions require the presence of the PrPC. Thus, the importance of this investigation for the location of the PrPC in the central nervous system.

(Department of Anatomy at the University of Navarra) Knowing where in the central nervous system the prions operate

Locating the PrPC meant being able to identify which places in the central nervous system the prions operate. The findings enabled the research team to establish that the PrPC is a protein involved in the neuronal metabolism of calcium. Moreover, the existence of neurones without PrPC and surrounded by perineuronal nests breaks with the hypothesis, to date, that the disappearance of such nests – a special form of extracellular matrix – is a primary event in the course of spongiform encephalopathies; rather it is secondary event.

According to the researchers' observations, the loss of these nests and consequent neuronal death are due to the damage produced after the appearance of the prions in the brain, where they act upon such perineuronal nests, amongst other structures.

According to the researchers' comments, extrapolating these results from the rat to the human is valid, given that similar results had been obtained after carrying out the study on human brains. Moreover, this work and others carried out on the brains of the autochthonous Pyrenees breed of cow will help to explain the operating mechanisms of the prions in bovine spongiform encephalopathy.

This study, published in Brain Research, is an addition to the work of the Department of Pathological Histology and Anatomy at the U niversity of Navarra regarding the manner in which prions enter the digestive tube of bovine animals, from which organ they enter the central nervous system, causing the mad cow disease or bovine spongiform encephalopathy.

'"/>




Related medicine news :

1. Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease
2. Vitamins-The answer to Heart Disease?
3. Link between Constipation and Parkinsons Disease
4. Levels Of Blood Proteins May Help Heart Disease Care
5. New Drug PP188 Helps Sickle Cell Disease
6. Gene Treatment for Heart Disease
7. Legume Consumption Can Cut Heart Disease Risk
8. Link Between Infection And Heart Disease
9. Celiac Disease in Type 1 Diabetes
10. Shunt for Alzheimers Disease
11. High iron levels may cause Cardiovascular Disease in women
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior TV ... the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will stream ... Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food Warriors ...
(Date:2/5/2016)... CA (PRWEB) , ... February 05, 2016 , ... ... to announce the addition of micro-needling services in their Napa Valley office. The ... founders of Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are part of ...
(Date:2/5/2016)... Miami, Florida (PRWEB) , ... February 05, 2016 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – is poised to once again host, Swirl, A Wine Tasting Event ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: ... wait longer to access the treadmills. It’s a predictable trend. After the excesses of ... and get in shape by joining gyms, starting new walking or running routines, or ...
(Date:2/5/2016)... , ... February 05, 2016 , ... At its annual ... Patrick McDermott as Chairman of the National Board of Directors. Mr. McDermott succeeds former ... the Board,” stated Leslie A. Chambers , APDA President and CEO. “Pat has ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 Aethlon Medical, Inc. (Nasdaq: ... Chairman and CEO, will be presenting at Source Capital Group,s ... York, NY at 2:15 p.m. ET on Wednesday, ... Immunotherapy Panel discussion taking place at 3:15 p.m. ET. ... approximately one hour after the conclusion of the live event. ...
(Date:2/5/2016)... Feb. 5, 2016  Zimmer Biomet Holdings, Inc. (NYSE ... previously announced underwritten secondary offering of 11,027,558 shares of ... of affiliates of Blackstone and Goldman Sachs.  The shares ... price of $96.45 per share. The selling stockholders will ... Zimmer Biomet nor any of its directors, officers or ...
(Date:2/5/2016)... France , Germany ... and Israel ). It includes a 10-year epidemiology forecast ... segmented by age and sex in these markets. GD epidemiology report is ... in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends ... Germany , Italy , Spain ...
Breaking Medicine Technology: