Navigation Links
The Link Between Rheumatoid Arthritis and Cancer

Patients with rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, have a high risk of death from disease – at least double// the risk of the general population, studies overwhelmingly show. Evidence has been less clear on whether RA patients are exceptionally vulnerable to dying from cancer.

The first study to investigate whether patients with RA who develop cancer have a decreased rate of survival, featured in the issue of Arthritis & Rheumatism, also examined the impact of rheumatic disease on overall cancer incidence. Conducted by a team of researchers in the United Kingdom, it focused on 2,105 patients with recent onset inflammatory polyarthritis (IP). Over time, a large proportion of new-onset IP cases evolve into RA, meeting the diagnostic criteria of the American College of Rheumatology.

Researchers followed the IP patients over a 10-year period to detect the occurrence of cancer. Among the group, they identified 123 cases of cancer for analysis. These cases included bone, lung, breast, prostate, urinary, colon, and brain cancers; cancers of the digestive, respiratory, and central nervous systems; cancers of the blood cells and cancerous tumors; but excluding non-melanotic skin cancers. Then, they compared these rates with the rates of cancer in the general population from the same geographic area, Norfolk, adjusting for difference in age and sex. Overall, the incidence of cancer was not increased in the IP subjects compared with the general population. However, the risk of blood cell cancers was increased among the IP sample, a finding researchers expected given the association between RA and lymphoma.

The study also compared the number of deaths in patients with cancer and inflammatory arthritis with that of cancer patients without a history of inflammatory arthritis. The finding was striking: a 40 percent increase in mortality in patients who suffered both IP, or RA, and cancer.

"The resul ts of this study demonstrated that 5-year cancer survival in patients with IP is substantially reduced in comparison with that in the general population, even after adjusting for differences in age, sex, and cancer site, whereas the overall cancer incidence does not seem to be increased," observes Alan Silman, M.D., an epidemiologist with the University of Manchester and the study’s leading researcher. Whether targeted cancer therapies could improve the survival rate for RA patients remains a subject for further research.


Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:

(Date:11/24/2015)... ... ... Bibliomotion is thrilled to announce the launch of UNCONVENTIONAL ... Nancy M. Schlichting, Chief Executive Officer of Henry Ford Health System (November ... of patients and their families, shaped my desire to improve the system of care. ...
(Date:11/24/2015)... FL (PRWEB) , ... November 24, 2015 , ... ... and engineer of patented products, announces Innovative Blending, a household invention that revolutionizes ... , "The Juice & Smoothie Bars market is worth $2 billion," says Scott ...
(Date:11/24/2015)... ... 2015 , ... World Patent Marketing , a vertically ... invention which offers a combination of natural essential oils to create something fragrantly ... $3 billion annually," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:11/24/2015)... ... , ... “I am so thrilled, as a newbie here, to leave a mark for the ... School Lounge Makeover® from California Casualty . Stephanie is in her fifth year teaching ... longer tenure. , “This is such an amazing school and we deserve a space where ...
(Date:11/24/2015)... ... November 24, 2015 , ... There’s nothing better than giving the gift of ... can enjoy. , This year, gardens are popping up in the most unexpected ... , Vita Gardens’ African Keyhole Garden Bed ($499) , Water conscious gardeners – ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Calif. , Nov. 24, 2015 Abaxis, ... manufacturing point-of-care instruments and consumables for the medical, research, ... Taylor , Chief Financial Officer, will present at the ... Tuesday, December 1, 2015 at 11:30 a.m. ET. The ... Palace in New York City . ...
(Date:11/24/2015)... Nov. 24, 2015   Mast Therapeutics, Inc. ... molecular adhesion and sealant technology (MAST) platform to develop ... stroke, today announced that the Company,s Chief Executive Officer, ... Piper Jaffray 27 th Annual Healthcare Conference on ... the New York Palace hotel in New ...
(Date:11/24/2015)... DIEGO , Nov. 24, 2015 Arena Pharmaceuticals, ... scheduled to present a corporate overview and update at the ... December 2, 2015, at 8:30 a.m. Eastern Time (5:30 a.m. ... New York City . . ... days following the event. Please connect to Arena,s website several ...
Breaking Medicine Technology: