Navigation Links
The Link Between Oxidized Phospholipids And Coronary Artery Disease

According to a recent study published for the first time, researchers have made the first causal connection between concentrations of oxidized phospholipids and the risk of coronary artery disease (CAD).//

As levels were also closely related to those of Lp(a) lipoprotein, the researchers suggest that that the established ability of the latter to promote atherosclerosis may be partly mediated by the proinflammatory oxidized phospholipids that are bound to it.

Lp(a) lipoprotein is composed of apolipoprotein (apo) B-100, to which apo(a) is covalently bound.

Believing that oxidized phospholipids on lipoproteins containing apo B-100 may explain some of the atherogenic properties of Lp(a) lipoprotein, Sotirios Tsimikas (University of California, San Diego) examined whether oxidized phospholipid levels were related to CAD in 504 patients undergoing angiography. The oxidized phospholipid content per particle of apo B-100 - otherwise known as the oxidized phospholipid: apo B-100 ratio - was determined from oxidized low-density lipoprotein levels.

Researchers say that the ratio correlated strongly with Lp(a) lipoprotein levels, with both measures showing a strong and graded association with the presence and extent of CAD (p<0.001 in both cases). In patients aged 60 years or less, those in the highest quartiles for oxidized phospholipid: apo B-100 ratio (<0.294) were more likely than those in the lowest quartile (>0.047) to have CAD (41% vs 19%, odds ratio [OR]=3.12), and the same was true for Lp(a) lipoprotein levels (<39.7 vs >8.8 mg/dl, 61% vs 30%, OR=3.64, p<0.001 in both cases).

Results indicated that in all participants, the association of oxidized phospholipid: apo B-100 ratio with obstructive CAD was independent of all clinical and lipid measures, apart from Lp(a) lipoprotein. For individuals aged 60 years or under, the ratio remained an independent predictor of CAD.

In conclusion researcher s say that in settings of enhanced oxidative stress and elevated Lp(a) lipoprotein levels, a pro-inflammatory milieu may predominate that contributes to the clinical expression of cardiovascular disease.

According to another recent study researchers suggest that proteins and enzymes that remove or destroy oxidized phospholipids prevent atherosclerosis and that proteins and enzymes that produce or retain oxidized phospholipids promote atherosclerosis , hence they say that oxidized phospholipids can be also used as a diagnostic marker of CAD.


'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: