Navigation Links
The Link Between Oxidized Phospholipids And Coronary Artery Disease

According to a recent study published for the first time, researchers have made the first causal connection between concentrations of oxidized phospholipids and the risk of coronary artery disease (CAD).//

As levels were also closely related to those of Lp(a) lipoprotein, the researchers suggest that that the established ability of the latter to promote atherosclerosis may be partly mediated by the proinflammatory oxidized phospholipids that are bound to it.

Lp(a) lipoprotein is composed of apolipoprotein (apo) B-100, to which apo(a) is covalently bound.

Believing that oxidized phospholipids on lipoproteins containing apo B-100 may explain some of the atherogenic properties of Lp(a) lipoprotein, Sotirios Tsimikas (University of California, San Diego) examined whether oxidized phospholipid levels were related to CAD in 504 patients undergoing angiography. The oxidized phospholipid content per particle of apo B-100 - otherwise known as the oxidized phospholipid: apo B-100 ratio - was determined from oxidized low-density lipoprotein levels.

Researchers say that the ratio correlated strongly with Lp(a) lipoprotein levels, with both measures showing a strong and graded association with the presence and extent of CAD (p<0.001 in both cases). In patients aged 60 years or less, those in the highest quartiles for oxidized phospholipid: apo B-100 ratio (<0.294) were more likely than those in the lowest quartile (>0.047) to have CAD (41% vs 19%, odds ratio [OR]=3.12), and the same was true for Lp(a) lipoprotein levels (<39.7 vs >8.8 mg/dl, 61% vs 30%, OR=3.64, p<0.001 in both cases).

Results indicated that in all participants, the association of oxidized phospholipid: apo B-100 ratio with obstructive CAD was independent of all clinical and lipid measures, apart from Lp(a) lipoprotein. For individuals aged 60 years or under, the ratio remained an independent predictor of CAD.

In conclusion researcher s say that in settings of enhanced oxidative stress and elevated Lp(a) lipoprotein levels, a pro-inflammatory milieu may predominate that contributes to the clinical expression of cardiovascular disease.

According to another recent study researchers suggest that proteins and enzymes that remove or destroy oxidized phospholipids prevent atherosclerosis and that proteins and enzymes that produce or retain oxidized phospholipids promote atherosclerosis , hence they say that oxidized phospholipids can be also used as a diagnostic marker of CAD.


'"/>




Related medicine news :

1. Link Between Infection And Heart Disease
2. Prescription Drug Use Varies Widely Between States
3. Wait Between Pregnancies
4. Link Between Migraines and Behavioral Disorders
5. Link Between Obesity and Behavior in Kids
6. Link Between Mothers Depression and Violence in Children
7. Link Between Alcohol and Decrease in Brain Size
8. Link Between Musculoskeletal Pain and Vitamin D Deficiency
9. Link Between Hyperglycemia & Hospital Mortality
10. Link Between Alcohol Consumption And Cardiovascular Disease
11. Understanding The Link Between Hormone Replacement and Respiratory Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance ... greater Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to ... and deadly chromosome abnormality. , After struggling since birth with several health challenges, ...
(Date:10/13/2017)... ... , ... As health professionals work to improve their approach to healthcare, there ... more than filling out a survey; in many cases health professionals and patients are ... care and research on the importance of active engagement with patients and members of ...
(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... , ... October 13, 2017 , ... PurhealthRX , ... Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize ... providing a CBD form that can be easily incorporated into liquid products, while reducing ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
Breaking Medicine Technology: