Navigation Links
The Importance of Junk DNA

Scientists have only recently begun to speculate that whats referred to as junk DNA the 96 percent of the human genome that doesnt encode for proteins and previously seemed to have no useful purpose is present in the genome for an important reason.

But it wasnt clear what the reason was. Now, researchers at the University of California, San Diego (UCSD) School of Medicine have discovered one important function of so-called junk DNA.

Genes, which make up about four percent of the genome, encode for proteins, the building blocks of life.

An international collaboration of scientists led by Michael G. Rosenfeld, M.D., Howard Hughes Medical Investigator and UCSD professor of medicine, found that some of the remaining 96 percent of genomic material might be important in the formation of boundaries that help properly organize these building blocks. Their work will be published in the July 13 issue of the journal Science.

Some of the junk DNA might be considered punctuation marks commas and periods that help make sense of the coding portion of the genome, said first author Victoria Lunyak, Ph.D., assistant research scientist at UCSD.

In mice, as in humans, only about 4 percent of the genome encodes for protein function; the remainder, or junk DNA, represents repetitive and non-coding sequences. The research team studied a repeated genomic sequence called SINE B2, which is located on the growth hormone gene locus, the gene related to the aging process and longevity.

The scientists were surprised to find that SINE B2 sequence is critical to formation of the functional domain boundaries for this locus.

Functional domains are stretches of DNA within the genome that contain all the regulatory signals and other information necessary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence are b racketed by punctuation marks.

The researchers data suggest that repeated genomic sequences might be a widely used strategy used in mammals to organize functional domains.Without boundary elements, the coding portion of the genome is like a long, run-on sequence of words without punctuation, said Rosenfeld.

Decoding the information written in junk DNA could open new areas of medical research, particularly in the area of gene therapy.

Scientists may find that transferring encoding genes into a patient, without also transferring the surrounding genomic sequences which give structure or meaning to these genes, would render gene therapy ineffective.




'"/>




Related medicine news :

1. Importance of Fatty food In Hypercholestrolemia
2. Importance of soy protein in your diet
3. Importance of type of sex in organ transplantation
4. Importance of An Active Lifestyle
5. Importance of An Active Lifestyle
6. The Importance Of “ Good ”Control Of Diabetes During Pregnanc
7. The Importance Of Skin Cancer Screening
8. The Importance Of Folic Acid Supplements
9. The Importance Of Vitamin D Supplements
10. More Importance To Be Given To Prenatal Nutrition
11. Beauty Queens Urge On The Importance Of Maintaining Bone Integrity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2017)... ... 2017 , ... In its just released 2018 Edition, The Best Lawyers in ... the third consecutive year that Hardiman and Mills have been honored and the seventh ... in Health Care Law while Mills was recognized in the Administrative and Regulatory Law ...
(Date:8/17/2017)... ... August 17, 2017 , ... SeQuel Response announced today that for ... among the fastest-growing private companies in the U.S., putting it in the top 10 ... applied to the Inc. 5000 over the years, only a fraction have ...
(Date:8/17/2017)... ... August 17, 2017 , ... An August 2 article on NextShark ... surgery, largely influenced by the growing popularity of “pretty boys” in both K-Pop and ... standards of male appearance are changing not only in the Asian nation, where plastic ...
(Date:8/17/2017)... Mesa, CO (PRWEB) , ... August 17, 2017 ... ... & Moral Injury: The Journey to Healing Through Forgiveness ($15.99, paperback, 9781498497626; ... disorder (war) trauma, to encourage inner healing of memories and achieve forgiveness, through ...
(Date:8/17/2017)... ... 17, 2017 , ... Inc. Magazine Unveils 36th Annual List of America’s Fastest-Growing ... Growth of 3,004.8% , NEW YORK, August 16, 2017 – Inc. magazine today ranked ... of the nation's fastest-growing private companies. The list represents a unique look at the ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Fenita J. Caldwell is ... Lifetime Professional in the Field of Healthcare. Caldwell ... Pharmaceuticals, AG. Her skills and areas of expertise ... Fenita ... experience as a highly successful sales specialist in ...
(Date:8/1/2017)... , Aug. 1, 2017   CerSci Therapeutics , ... Dallas, Texas , has received notice from the ... Institutes of Health (NIH) that it has been awarded ... totaling over $650,000 in 2017 with an additional $1,000,000 ... Investigational New Drug application of their lead non-opioid drug ...
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today announced financial ... 2017, and updated its financial outlook for fiscal 2017. ... fiscal third quarter, Hill-Rom reported earnings of $0.09 per ... the prior-year period. These results reflect after-tax special items, ... related to the non-cash write-down of assets associated with ...
Breaking Medicine Technology: