Navigation Links
The Importance of Junk DNA

Scientists have only recently begun to speculate that whats referred to as junk DNA the 96 percent of the human genome that doesnt encode for proteins and previously seemed to have no useful purpose is present in the genome for an important reason.

But it wasnt clear what the reason was. Now, researchers at the University of California, San Diego (UCSD) School of Medicine have discovered one important function of so-called junk DNA.

Genes, which make up about four percent of the genome, encode for proteins, the building blocks of life.

An international collaboration of scientists led by Michael G. Rosenfeld, M.D., Howard Hughes Medical Investigator and UCSD professor of medicine, found that some of the remaining 96 percent of genomic material might be important in the formation of boundaries that help properly organize these building blocks. Their work will be published in the July 13 issue of the journal Science.

Some of the junk DNA might be considered punctuation marks commas and periods that help make sense of the coding portion of the genome, said first author Victoria Lunyak, Ph.D., assistant research scientist at UCSD.

In mice, as in humans, only about 4 percent of the genome encodes for protein function; the remainder, or junk DNA, represents repetitive and non-coding sequences. The research team studied a repeated genomic sequence called SINE B2, which is located on the growth hormone gene locus, the gene related to the aging process and longevity.

The scientists were surprised to find that SINE B2 sequence is critical to formation of the functional domain boundaries for this locus.

Functional domains are stretches of DNA within the genome that contain all the regulatory signals and other information necessary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence are b racketed by punctuation marks.

The researchers data suggest that repeated genomic sequences might be a widely used strategy used in mammals to organize functional domains.Without boundary elements, the coding portion of the genome is like a long, run-on sequence of words without punctuation, said Rosenfeld.

Decoding the information written in junk DNA could open new areas of medical research, particularly in the area of gene therapy.

Scientists may find that transferring encoding genes into a patient, without also transferring the surrounding genomic sequences which give structure or meaning to these genes, would render gene therapy ineffective.




'"/>




Related medicine news :

1. Importance of Fatty food In Hypercholestrolemia
2. Importance of soy protein in your diet
3. Importance of type of sex in organ transplantation
4. Importance of An Active Lifestyle
5. Importance of An Active Lifestyle
6. The Importance Of “ Good ”Control Of Diabetes During Pregnanc
7. The Importance Of Skin Cancer Screening
8. The Importance Of Folic Acid Supplements
9. The Importance Of Vitamin D Supplements
10. More Importance To Be Given To Prenatal Nutrition
11. Beauty Queens Urge On The Importance Of Maintaining Bone Integrity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... Whippany, New Jersey (PRWEB) , ... February 11, 2016 , ... ... invited to a free CEU seminar titled, “Stroke Management: Time to Act, Time to ... Senior Housing Community in Whippany, N.J. The presenter is Vishal Chedda, president of ...
(Date:2/11/2016)... ... February 11, 2016 , ... The president released a FY 2017 budget request ... shift more of the cost burden to military beneficiaries. , MOAA’s president, retired ... defense budget as including limited quantifiable benefit fixes mixed with numerous beneficiary fee hikes. ...
(Date:2/11/2016)... ... February 11, 2016 , ... In a new ... plastic surgeon , Dr. Rod J. Rohrich, and colleagues, examine and underscore the ... recommendations for rhinoplasty surgeons when addressing this vital area. , The upper lateral ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of J.R. Garrett Esq. as General Counsel. Garrett will focus on contract negotiations, ... and audits, privacy and security law, and best practices in data breaches for ...
(Date:2/11/2016)... ... 11, 2016 , ... Talix today announced that Clive Fields, ... presenting at the 2016 HIMSS Annual Conference & Exhibition, taking place February 29 ... “ Coding for Care: Using Data Analytics for Risk Adjustment ,” Dr. Fields ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Delcath Systems, ... and medical device company focused on oncology with ... metastatic liver cancers, announces the engagement of ... Company,s Global Medical Consultant. Dr. Birgerson will provide ... Company,s clinical operations team to help ensure timely ...
(Date:2/11/2016)... 11, 2016 SI-BONE, Inc., a medical ... iFuse Implant System, a minimally invasive surgical (MIS) ... the sacroiliac (SI) joint, announced the publication of ... MIS SI joint fusion for patients suffering from ... or SI joint disruption.  In the first article, ...
(Date:2/11/2016)... Inc. (NASDAQ: IONS ) announced today that it will ... a.m. Eastern Time to discuss its 2015 financial results and ... . A webcast replay will be available for a limited ... A webcast replay will be available for a limited time ... listen to the call by dialing 877-443-5662 or access the ...
Breaking Medicine Technology: