Navigation Links
The Importance of Junk DNA

Scientists have only recently begun to speculate that whats referred to as junk DNA the 96 percent of the human genome that doesnt encode for proteins and previously seemed to have no useful purpose is present in the genome for an important reason.

But it wasnt clear what the reason was. Now, researchers at the University of California, San Diego (UCSD) School of Medicine have discovered one important function of so-called junk DNA.

Genes, which make up about four percent of the genome, encode for proteins, the building blocks of life.

An international collaboration of scientists led by Michael G. Rosenfeld, M.D., Howard Hughes Medical Investigator and UCSD professor of medicine, found that some of the remaining 96 percent of genomic material might be important in the formation of boundaries that help properly organize these building blocks. Their work will be published in the July 13 issue of the journal Science.

Some of the junk DNA might be considered punctuation marks commas and periods that help make sense of the coding portion of the genome, said first author Victoria Lunyak, Ph.D., assistant research scientist at UCSD.

In mice, as in humans, only about 4 percent of the genome encodes for protein function; the remainder, or junk DNA, represents repetitive and non-coding sequences. The research team studied a repeated genomic sequence called SINE B2, which is located on the growth hormone gene locus, the gene related to the aging process and longevity.

The scientists were surprised to find that SINE B2 sequence is critical to formation of the functional domain boundaries for this locus.

Functional domains are stretches of DNA within the genome that contain all the regulatory signals and other information necessary to activate or repress a particular gene. Each domain is an entity unto itself that is defined, or bracketed, by a boundary, much as words in a sentence are b racketed by punctuation marks.

The researchers data suggest that repeated genomic sequences might be a widely used strategy used in mammals to organize functional domains.Without boundary elements, the coding portion of the genome is like a long, run-on sequence of words without punctuation, said Rosenfeld.

Decoding the information written in junk DNA could open new areas of medical research, particularly in the area of gene therapy.

Scientists may find that transferring encoding genes into a patient, without also transferring the surrounding genomic sequences which give structure or meaning to these genes, would render gene therapy ineffective.




'"/>




Related medicine news :

1. Importance of Fatty food In Hypercholestrolemia
2. Importance of soy protein in your diet
3. Importance of type of sex in organ transplantation
4. Importance of An Active Lifestyle
5. Importance of An Active Lifestyle
6. The Importance Of “ Good ”Control Of Diabetes During Pregnanc
7. The Importance Of Skin Cancer Screening
8. The Importance Of Folic Acid Supplements
9. The Importance Of Vitamin D Supplements
10. More Importance To Be Given To Prenatal Nutrition
11. Beauty Queens Urge On The Importance Of Maintaining Bone Integrity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... , ... They are musicians and librarians, fashion designers and fitness instructors, actors, ... England and around the nation. What do they have in common? All have been ... and compelling new photographic exhibit debuting Friday, December 9 at Logan International Airport in ...
(Date:12/7/2016)... ... 07, 2016 , ... The Cliff Hart Agencies, a Michigan-based ... Dewitt, Williamston, East Lansing, Ann Arbor, and Farmington Hills, is announcing a regional ... tumor. , Jason Bauer and his family are longtime members of the Williamston ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... One of ... changing of the securement tape is painful for her. "This is why the co-inventor ... patients’ heads," she said. , They then created a prototype of the patent-pending AV-AIR, ...
(Date:12/7/2016)... ... OCTOBER XX, 2016 (PRWEB) (PRWEB) December 07, 2016 , ... ... entitled “Canine Filamentous Dermatitis Associated with Borrelia Infection” reveals that ... was published in the prestigious Journal of Veterinary Science & Medical Diagnosis. , ...
(Date:12/7/2016)... ... ... Facial plastic surgeon, Dr. John D. Rachel of Timeless You™ Chicago , ... local organizations: North Chicago Animal Control and Friends and Our House of Hope Rescue. ... and trained volunteers who support rescued animals held in the City of North Chicago’s ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... , Dec. 7, 2016  The Corporate Whistleblower ... manager to call them anytime at 866-714-6466 if they ... to sell more drugs. Aside from the innocent patients ... as well, because often-times these practices target Medicare recipients or ... ...
(Date:12/7/2016)... Dec. 7, 2016   TraceLink Inc ., ... connecting the Life Sciences supply chain and eliminating ... announced that Tjoapack has selected TraceLink,s serialization solutions ... comply with the rapidly approaching serialization deadlines for ... in 2017 and the EU Falsified Medicines Directive ...
(Date:12/7/2016)... 2016 According to responses from U.S. oncologists that ... of patients with non-small cell lung cancer (NSCLC), treatment decisions ... genetic mutation status. The findings of the survey were presented ... #P3.02b ) at the 2016 World Conference on Lung ... The survey results revealed an overall high rate of ...
Breaking Medicine Technology: