Navigation Links
The Downside of Asthma Medication

Could a common class of drugs used for acute asthma attacks be causing the very thing it aims to treat?//

Perhaps, find researchers from Harvard School of Public Health and Brigham and Women’s Hospital who studied the use of bronchodilators known as beta-agonists in asthmatics.

Beta-agonists are the primary treatment used to relieve acute asthma attacks. The drugs come in many forms -- they may be delivered with an inhaler, given in pill or liquid form, delivered in a nebulizer, or given by injection. Whatever the mode of administration, they work by relaxing the airway and reducing airway responsiveness to allergens that cause it to restrict and cause an acute attack. Many people with asthma rely heavily on these medications, sometimes taking them several times a day. Previous research suggests regular use could increase sensitivity to airway constriction and thus lead to a greater number of attacks and more serious attacks, primarily by causing a desensitization of the beta2-adrenergic receptor (beta2AR) that the drug binds with to achieve its effects.

These researchers suggest an alternative mechanism. Their study finds the increased airway hyperresponsiveness seen in some regular users of beta-2 agonists may be due to increased expression of a substance called phospholipase C-beta (PLC-beta) in the smooth airway muscle that occurs with persistent high-level activation of the beta2AR. The finding may lead to new treatments for asthma targeting PLC-beta.

Writing in an accompanying commentary, other researchers from Harvard and Brigham and Women’s concur, noting, “Understanding the panoply of beta2AR-mediated events in airway smooth muscle might lead to the design of new agonists that avoid negative effects of beta2AR activation while enhancing events that lead to relaxation.”

'"/>




Page: 1

Related medicine news :

1. Downside of Diets in Children
2. New Drug for Bronchial Asthma
3. Asthma may actually be prevented by Dust and Dirt
4. Inhaled Steroids Safe & Effective for Children with Asthma
5. What happens when Asthmatics consume Aspirin?
6. Asthma! A new warning for heart disease
7. Asthma linked to obesity
8. Higher Risk of Asthma in children with autoimmune disease
9. Asthmatics at increased risk of lung cancer
10. Cleanliness might lead to Asthma
11. Asthma is not just a childhood condition
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The Downside Asthma Medication

(Date:4/27/2015)... April 27, 2015 Array Health ... technology, has announced that Lance Hood, senior director of ... fourth annual Direct-to-Consumer Health Care Marketing Summit ... David Smith, Partner and Director of Payer Services, Leavitt ... care consumerism – through a retail/e-commerce perspective – and ...
(Date:4/27/2015)... April 27, 2015 Ticket Down is a ... Philadelphia for his upcoming concert on Sunday, June 21st. ... thrill his countless North American fans again in 2015 when ... his "Out There" tour. He will be performing in ... to listen to this legendary performer for the first time ...
(Date:4/27/2015)... Thanks to a $7.5 million grant ... half-dozen institutions, including American University, will operate in a ... and behavioral research aimed at ending the AIDS epidemic. ... with HIV or AIDS, according to the latest statistics. ... population over the age of 13 was living with ...
(Date:4/27/2015)... Angeles, CA (PRWEB) April 27, 2015 The ... has been to connect clients of personal injury attorneys with ... network of doctors has seen steady growth throughout their history ... Charles E. Richardson, DC and his team in the ... including a medical doctor and massage therapist, patients can find ...
(Date:4/27/2015)... April 27, 2015 Sitting or standing for ... and feel tired, and for those whose occupation requires them ... and taxi cab drivers, or to be on their feet ... the discomfort can be more severe and longer lasting. These ... syndrome. Dr. Madaiah Revana of Northeast Houston Vein Center is ...
Breaking Medicine News(10 mins):Health News:Array Health’s Senior Director of Marketing to Present at The Fourth Annual Direct-to-Consumer Health Care Marketing Summit 2Health News:Paul McCartney Presale Tickets at Wells Fargo Center in Philadelphia: Ticket Down Slashes Paul McCartney Ticket Prices in Philadelphia at the Wells Fargo Center 2Health News:D.C. Center for AIDS Research Established with New Grant from NIH 2Health News:D.C. Center for AIDS Research Established with New Grant from NIH 3Health News:Prominent Doctors with Distinguished Backgrounds Join Doctors on Liens in Tujunga 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 2Health News:Northeast Houston Vein Center Offers Tips on How to Treat Achy Legs 3
... Feb. 26 AIDS Action congratulates Jeffrey Crowley, an ... health care and HIV/AIDS for his appointment as Director ... He joins a well-respected and dedicated team in the ... and reports to Director Melody Barnes who has a ...
... inhibit both normal and virulent strains, study finds ... Combination treatment with two FDA-approved drugs shows promise ... study shows. , In laboratory tests, researchers at ... National Institute of Allergy and Infectious Diseases found ...
... The number of Americans traveling abroad for healthcare is ... trend as the recession worsens and more Americans are left ... to the Deloitte Centre for Health Solutions, the number of ... million in 2010 and 15.75 million by 2017. The $16 ...
... Ignagni, President and CEO of America,s Health Insurance Plans, ... President,s budget:"Today,s budget submission sends a signal to the ... health care. We applaud the President for laying ... to put our nation on a path towards comprehensive ...
... Consultancy, is pleased to announce the launch of a further nine ... listings to relevant specialist industries. , ... (PRWEB) February ... & Marketing Consultancy , is pleased to announce the launch of ...
... RALEIGH, N.C., Feb. 26 Arbor Pharmaceuticals, a ... that the company has launched XYLAREX - a ... otitis media (middle ear,infections). XYLAREX is a ... reduce the number of ear infections children experience. ...
Cached Medicine News:Health News:AIDS Action Applauds President on Appointment of Jeffrey Crowley as Director of National AIDS Policy 2Health News:Antibiotic Combo Fights Resistant TB 2Health News:Americans Will Soon Have Medical Butlers to Assist in Medical Tourism Research 2Health News:AHIP Statement on the President's Budget 2Health News:Simply Marcomms Launch New Specialist Online Industry Directories 2Health News:Arbor Pharmaceuticals Announces the Launch of XYLAREX(TM) - A New Nonantibiotic Product for the Dietary Management of Recurrent Ear Infections in Children 2
(Date:4/27/2015)... , April 27, 2015 Harwood Feffer LLP ... board of directors of Aerie Pharmaceuticals, Inc. ("Aerie" or ... board has breached its fiduciary duties to shareholders. ... press release announcing results from its first Phase 3 ... release disclosed that in the trial, Rhopressa failed to ...
(Date:4/27/2015)... , April 27, 2015 ... the addition of the "Endoscopy Global Market ... offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... approximately $43 billion by 2019 growing at around ... drivers for the market growth are aging population, ...
(Date:4/27/2015)... AUSTIN, Texas , April 27, 2015 ... solutions company focused on gynecologic disease, announced ... financial results after the market close on ... investor conference call and webcast at 4:30pm ... 2015 at 4:30pm Eastern/1:30pm Pacific Domestic: , ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Aerie Pharmaceuticals, Inc. 2Endoscopy Global Market - Forecast to 2020: Market is expected to reach approximately $43 billion with Johnson and Johnson, Olympus and Covidien Dominating 2Endoscopy Global Market - Forecast to 2020: Market is expected to reach approximately $43 billion with Johnson and Johnson, Olympus and Covidien Dominating 3
Mayfield Disposable Adult (plastic) Skull Pins are designed for rigid skeletal fixation....
Endoscopes...
Short system ventriculoscope for free hand use....
Preclude Dura Substitute is the only non-biological membrane designed to "seal" around suture holes. 0.3 mm as nominal thickness....
Medicine Products: