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The Dengue Virus Unplugged

on feature of this virus, said Gamarnik. 'We now recognize that it serves a role in bringing the SLA promoter near the initiation site.'

Paul Ahlquist, an HHMI investigator at the University of Wisconsin-Madison and an expert on RNA viruses, said that the Gamarnik team's findings explain prior observations from her lab and others that binding between the 5-prime and 3-prime ends of the viral genome is required for replication of dengue and several other medically important flaviviruses. "These insights suggest possible mechanisms by which flaviviruses may regulate some distinct replication steps, and might ultimately provide foundations for new antiflavivirus strategies, Ahlquist said.

Source : Eureka Alert


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