Navigation Links
The Combo Treatment Is Effective to Treat Type 1 Diabetes in Mice

According to the researchers from the La Jolla Institute for Allergy and Immunology a combination treatment in mice is found to be very effective against Type 1 diabetes. //According to the Centers for Disease Control and Prevention in Atlanta, Type 1 diabetes or juvenile diabetes, accounts for up to 10 % of the 18 million cases of diabetes in the United States. Type 1 diabetes appears most often in childhood or adolescence stage.

It occurs when the immune system destroys the insulin-producing beta cells of the pancreas. Insulin is needed to control blood sugar levels. Insulin is a hormone that allows sugar to enter cells and be converted to energy. Without insulin, sugar and fats remain in the bloodstream and eventually damage the body's organs. Heart disease, blindness, kidney failure and the need for amputations are a few of diabetes' complications. On the other hand Type 2 diabetes is linked to obesity and physical inactivity. It usually affects people older than 40 years of age. It is characterized by the body's inability to produce enough insulin or properly use the insulin it produces.

Scientists at the La Jolla Institute for Allergy and Immunology said human trials using the new technique would begin late this year. The results of the findings were published in the online Journal of Clinical Investigation. The researchers injected antibodies called anti-CD3 into the mice to prevent the immune system's attack on insulin-producing beta cells in the animals' pancreas. In addition to this small chain molecules called nasal proinsulin peptides were also injected. This acts like a vaccine thereby triggering the production of a cell that specifically protects beta cells. A team led by Matthias von Herrath was able to stop the immune systems in most of the mice from destroying their own beta cells by using the combination of both these methods.

Von Herrath said that the mice did not have diabetes, again during their lifespan. Dr. Richard A. Insel, executive vice president for research at the Juvenile Diabetes Research Foundation International in New York City said that this finding contributed in a very important way. The rodents also experienced fewer side effects. Scientists have previously tested anti-CD3 antibodies and nasal proinsulin peptides separately in human clinical trials. They have never used the two therapies together. A couple of clinical trials in humans have shown that anti-CD3 antibodies alone reverse the recent onset of Type 1 diabetes, but only for about a year.

Von Herrath said that human clinical trials for the combination treatment still require regulatory approval. He and his colleagues are pursuing funding for the trials from the Diabetes Vaccine Development Centre in Australia and the National Institutes of Health in Washington, D.C. The trials would be directed at people recently diagnosed with Type 1 diabetes, or who are being treated as pre-diabetic. Mitchell Kronenberg, president and scientific director of the La Jolla Institute for Allergy and Immunology said that the new treatment would replace the daily insulin injections and prevent the long-term detrimental effects of diabetes.


'"/>




Related medicine news :

1. Drug Combo Works Better for children with ADHD, Tics
2. Scanning Combo Helps Detect Lung Cancer
3. Relief From Asthma With New Combo Therapy
4. Calcium-Vitamin D Combo For Reduced Fracture Risk
5. Drug Combo Improves Performance Of Multiple Sclerosis Drug
6. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
7. HER-2 Positive Breast Cancer Patients May Benefit With a Combo Drug Strategy
8. Doomed Duo: Obesity and Type 2 Diabetes Combo, Can Nip Life in the Bud
9. Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings
10. Fuzeon and MK-0518 Combo Holds Promise For HIV
11. Germ - Chemo Combo Fights Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... ... the University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® ... The program, developed in association with efforts by the American College of Surgeons, ...
(Date:3/28/2017)... ... March 28, 2017 , ... Award-winning medical group Allied ... as new board chair for Orange County health care system CalOptima Friday. CalOptima ... soon-to-be former chair Mark Refowitz’s term, which runs through June 30 of this ...
(Date:3/28/2017)... ... March 28, 2017 , ... In its ongoing effort ... has recently developed and published an informational resource that addresses frequently asked questions. ... common inquiries the site’s team of third party administrator (TPA) contributors regularly receives ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System ... procedure adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... Oily skin is a common and unwelcomed ... Advanced Dermatology has a lot to offer to the discussion of dealing with excess ... is that there are many home remedies that can help remove the oily shine while ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TEL AVIV, Israel , March 28, 2017 ... . This new business entity, Emosis Ltd, headquartered in ... and development of novel assays complementing the mother company existing technology ... support commercialization and sales development of Emosis kits. ... This strategic move starts building Emosis ...
(Date:3/28/2017)... , March 28, 2017  AcelRx Pharmaceuticals, ... on the development and commercialization of innovative therapies ... that the European Medicines Agency (EMA) has notified ... 30 mcg) Marketing Authorisation Application (MAA) has passed ... MAA is underway. The MAA for ARX-04 (known ...
(Date:3/28/2017)... RXi Pharmaceuticals Corporation (NASDAQ: RXII), a ... significant unmet medical needs, today announced that it ... Office (JPO) for the composition of matter of ... the treatment or prevention of fibrotic disorders, including ... retinopathy (Japanese Patent #: 6060071).  This patent includes ...
Breaking Medicine Technology: