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The Benefits of Strontium in the treatment for Osteoporosis Questioned

um not incorporated into bone is excreted through the kidneys and feces. After three years' treatment with strontium ranelate, bone tissue will contain around one strontium atom for every 100 calcium atoms. No human studies have yet reported how quickly bone strontium is washed out once treatment is stopped.

An impressive increase in bone mineral density occurred in the spine (14.4%) and hip (8.3%).7. However, some caution is necessary in interpreting these figures because much of this effect is due to the higher atomic number of strontium (Z = 38) compared with calcium (Z = 20).

Bone biopsy was performed in a subset of patients after the adjustment for bone strontium, the measured effect of treatment on bone mineral density in the spine of 14.4% was corrected to 8.1%.7.

The important issue for treatment for osteoporosis is prevention of fractures and not changes in bone mineral density. Caution is therefore needed in predicting efficacy against fractures simply on the basis of a change in bone mineral density.

An increase of 5% in spine bone mineral density is required to confirm a notable response to treatment. With strontium ranelate, large increases in bone mineral density are often seen, and if this is the case one can be confident that the patient is complying with treatment. The issue of patients' long-term use and compliance with treatment is important for all types of treatment for osteoporosis.
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