Navigation Links
The Benefits of Strontium in the treatment for Osteoporosis Questioned

Strontium ranelate for the treatment of osteoporosis is useful, but changes in bone// mineral density need careful interpretation. Nowadays the main treatment options are anti-resorptive agents that prevent bone breakdown.

For patients with previous fractures, treatment with an anabolic agent that enhances bone formation is preferable, and this is now possible since the introduction of recombinant parathyroid hormone (PTH). However, the use of PTH is limited by its high cost and the need for subcutaneous self-injection.

Recently strontium ranelate has been licensed in the United Kingdom for the treatment of osteoporosis. The mechanism of action of strontium ranelate is not yet fully understood, compared with other treatments, but it seems to have a unique effect in that it inhibits bone resorption as well as stimulating bone formation. Recent studies have shown its efficacy at preventing both vertebral and non-vertebral fractures, including hip fractures in older women. Strontium ranelate was well tolerated in these trials and the most common side effects reported were nausea and diarrhea.

Strontium ranelate is composed of two atoms of stable strontium combined with organic ranelic acid. The ranelic acid is a carrier that makes the treatment palatable, and the strontium is the active component with regard to the skeleton. As an alkaline earth element, strontium is similar to calcium in its absorption in the gut, incorporation in bone, and elimination from the body through the kidneys.

Strontium is naturally present in trace amounts with around 100 μg in every gram of bone, so treatment with strontium ranelate is simply making more strontium available for incorporation into bone. In the short term the strontium atoms are adsorbed on to the surface of hydroxyapatite crystals, and in the longer term some strontium will exchange with calcium in the bone mineral and may remain bound in the skeleton for years.

Stronti um not incorporated into bone is excreted through the kidneys and feces. After three years' treatment with strontium ranelate, bone tissue will contain around one strontium atom for every 100 calcium atoms. No human studies have yet reported how quickly bone strontium is washed out once treatment is stopped.

An impressive increase in bone mineral density occurred in the spine (14.4%) and hip (8.3%).7. However, some caution is necessary in interpreting these figures because much of this effect is due to the higher atomic number of strontium (Z = 38) compared with calcium (Z = 20).

Bone biopsy was performed in a subset of patients after the adjustment for bone strontium, the measured effect of treatment on bone mineral density in the spine of 14.4% was corrected to 8.1%.7.

The important issue for treatment for osteoporosis is prevention of fractures and not changes in bone mineral density. Caution is therefore needed in predicting efficacy against fractures simply on the basis of a change in bone mineral density.

An increase of 5% in spine bone mineral density is required to confirm a notable response to treatment. With strontium ranelate, large increases in bone mineral density are often seen, and if this is the case one can be confident that the patient is complying with treatment. The issue of patients' long-term use and compliance with treatment is important for all types of treatment for osteoporosis.
'"/>




Related medicine news :

1. Benefits in fertility procedures
2. Benefits of Vitamin Supplements Unclear
3. Benefits of Eating Whole Grains, Fruits and Vegetables
4. Benefits of Nitric Oxide in the Treatment of Premature Infants
5. Benefits and Risks of Asthma Treatment Questioned
6. Benefits Of The Worlds Most Widely Used Beverage
7. Drug In Asthma inhaler Found To Counteract Benefits
8. The Benefits Of Keyhole Surgery
9. The Benefits Of A Stretch
10. A Reduction In Calories Found To Yield More Benefits
11. The Benefits Of Soy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... ... industry, ranked among the top five firms in the “2015/2016 Best in KLAS: ... Support and Staffing. KLAS is a research and insights firm on a global ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... advocates will discuss how to improve care by making data on heart procedures ... disease. The Summit on Transparency and Public Reporting of Pediatric and Congenital Heart ...
(Date:2/11/2016)... ... ... In a new paper published in the latest issue ... Rohrich, and colleagues, examine and underscore the importance of upper lateral cartilage in ... this vital area. , The upper lateral cartilage in rhinoplasty, refers to a ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... decision support technology, with highly adaptable algorithms, has been updated to help Emergency ... signs and symptoms consistent with Zikas and a travel history to affected regions, ...
(Date:2/11/2016)... ... February 11, 2016 , ... "What holds you back ... Clarke poses a question as a challenge for his readers to examine the ... the Being" (published by Partridge Singapore), Clarke explores the subject with more depth, ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016  Governor Andrew M. Cuomo today announced ... jobs throughout Western New York . ... SUNY Polytechnic Institute, includes a major expansion of Athenex,s ... Buffalo , as well as the creation ... Dunkirk . The combined projects are ...
(Date:2/11/2016)... 11, 2016  MiMedx Group, Inc. (NASDAQ: MDXG ... membrane and other birth tissues, human skin and bone, ... market advanced products and therapies, announced today that it ... Healthcare Conference in New York , ... Michael J. Senken , Chief Financial Officer and ...
(Date:2/11/2016)... -- Wearable posture tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or ... go, ALEX is said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers ...
Breaking Medicine Technology: