Navigation Links
Testosterone Replacement Therapy Appears Safe for Prostate

Preliminary research suggests that testosterone replacement therapy for men with low testosterone levels appears to have little effect //on the prostate gland, contrary to some reports that this therapy may be harmful, according to a study in the November 15 issue of JAMA, a theme issue on men's health.

Leonard S. Marks, M.D., of the Urological Sciences Research Foundation and University of California, Los Angeles, presented the findings of the study today at a JAMA media briefing on men's health in New York.

Testosterone replacement therapy (TRT) in aging men is a widespread, growing practice. According to pharmaceutical industry estimates, more than 1.8 million prescriptions for testosterone products were written in the United States in 2002, a 30 percent increase over the previous year and a 170 percent increase over the previous 5 years. In 2005, a total of 2.3 million prescriptions were written for these products. Serum levels of testosterone decline with age, and many aging men with low levels of the hormone may experience depression, sexual dysfunction, diminished lean body mass, muscle volume and strength, and reduced bone mineral density, according to background information in the article. Such changes, in association with low testosterone levels, have been called "male menopause."

Aspects of the syndrome may be improved with TRT, and most testosterone prescriptions are currently written for men older than 45 years, a demographic in which prostate disease is most common. Between 2 and 4 million men, nearly all in this "prostatic age group," may be candidates for treatment, the authors write. In men with advanced prostate cancer, testosterone administration often worsens the disease. Thus, when aging men receive supplemental testosterone, a primary concern is prostate safety. Even in men with no sign of prostate cancer, the possibility of stimulating growth in subclinical disease exists. Instances of prostate cancer in men receiving testosterone supplementation have been reported. When TRT is prescribed, careful monitoring for prostate disease is considered mandatory. But there is little information regarding the effects of TRT on prostate tissue in men.

Dr. Marks and colleagues conducted a randomized controlled trial to assess the effects of TRT on prostate tissue of 44 men, age 44 to 78 years, with low serum testosterone levels. The study was conducted between February 2003 and November 2004. Participants were randomly assigned to receive by injection 150 mg of replacement testosterone or matching placebo every 2 weeks for 6 months. Of the 44 men randomized, 40 had prostate biopsies performed both at baseline and at the end of the study and were included in the final analysis (TRT, n = 21; placebo, n = 19).

Testosterone replacement therapy increased serum testosterone levels to the mid-normal range with no significant change in serum testosterone levels in matched, placebo-treated men. In prostate tissue, TRT increased median (midpoint) androgen (male sex hormone) concentrations only slightly compared with baseline levels or between the 2 groups. No treatment-related change was observed in prostate histology, tissue biomarkers, gene expression, or cancer incidence or severity. Treatment-related changes in prostate volume, serum prostate-specific antigen, voiding symptoms, and urinary flow were slight.

"… under the conditions herein, including the biopsy to detect cancer performed pretreatment, a degree of prostate safety is defined for men undergoing TRT," the authors write. "The prostate risks to men undergoing TRT may not be as great as once believed, especially if the results of the pretreatment biopsy are negative. However, establishment of prostate safety for large populations of older men undergoing longer duration of TRT requires further study," the researchers conclude.

Source-Newswise
'"/>




Related medicine news :

1. Testosterone Replacement Therapy Safe If Monitored Appropriately
2. Low Testosterone Levels the Cause Of Depression In Men
3. The Use Of Testosterone Replacement Therapy Questioned
4. Depression In Men Could Be To Low Testosterone Levels
5. Testosterone patch for women Rejected For safety Reasons
6. Testosterone Patches Found To Increase Sexual Desire In Menopausal Women
7. Testosterone Therapy can improve sexual function in postmenopausal women
8. Fatherhood Found To Tame Men by Reducing Testosterone Levels
9. Testosterone levels could serve as a marker for determining risk of SIDS
10. Males Lifespan Shortened By Elevated Levels Of Testosterone
11. Study Indicates An Increased Risk Of Breast Cancer In Women Undertaking Estrogen and Testosterone Therapy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/16/2017)... ... August 16, 2017 , ... Any Lab Test Now® ... company ranked #4429 on the newly released, 36th annual Inc. 5000 , the ... look at the most successful companies within the American economy’s most dynamic segment — ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... doors. They celebrate 30 years in business this year, and they’re marking the ... tranquil space to serve their patients. , It stands to reason that, ...
(Date:8/16/2017)... ... August 16, 2017 , ... QualDerm Partners , a ... today announced Cumberland Skin Surgery and Dermatology has joined the company ... in both Hermitage and Lebanon, Tennessee, provides comprehensive general dermatology and skin cancer ...
(Date:8/16/2017)... ... 2017 , ... Maury Regional Health has announced a large-scale adoption of AccuVein ... devices, Maury Regional Medical Center is making vein visualization part of their standard of ... and more importantly, helps our staff members locate a vein that will provide good ...
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, FACS , is honored ... The annual list identifies the nation’s top physicians, in a variety of specialties. This ... the top of Castle Connolly’s coveted ranking. , Castle Connolly is the nation’s trusted ...
Breaking Medicine News(10 mins):
(Date:7/25/2017)... BARCELONA, Spain and CAMBRIDGE, Massachusetts ... SOM Biotech, specializing in repurposing drugs to treat rare nervous ... Therapeutics Inc. to clinically develop and market the drug SOM0226 ... reached, the drug achieved very promising results in a Phase ... A new office in the United ...
(Date:7/24/2017)... , July 24, 2017 IBM (NYSE: ... Gartner Magic Quadrant for Solid-State Arrays (SSA) for the fourth ... According to Gartner, "Vendors in the Leaders quadrant ... Completeness of Vision. A vendor in the Leaders quadrant has ... to drive the acceptance of new technologies. These vendors demonstrate ...
(Date:7/21/2017)... EDMONTON, Alberta , July 21, 2017 ... the University of Alberta in Edmonton, ... Nature,s partner journal, Schizophrenia 1 , demonstrating that ... of schizophrenia with 74% accuracy. This retrospective analysis ... specific symptoms in schizophrenia patients with significant correlation, ...
Breaking Medicine Technology: