Navigation Links
Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

Carol Greider, Ph.D., director and professor of molecular biology and genetics in the Johns Hopkins Institute of Basic Biomedical Sciences and colleagues have found that the length of telomeres is important// in ensuring that stem cells are able to divide indefinitely.

Telomeres are the ends of the chromosomes that protect genetic information while the chromosome is undergoing division. These are basically "repetitive stretches of DNA" designed to protect chromosomes. Every time a cell undergoes division, the chromosome ends shorten ultimately exposing the genetic information in the stem cell and preventing further division. But a protein called telomerase prevents this from happening and thus cells can divide "n" number of times. In the current study, the Johns Hopkins researchers say that stem cells did not retain their chromosome ends in mice that were engineered to have just half the normal amount of telomerase. "These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents," says Carol Greider. "This phenomenon could complicate the hunt for disease genes." The problem is that offspring inherit diseases through mutations in genes, but even in half-telomerase mice the disease is still present although the genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice develop disease only because their telomeres are short, and having telomerase doesn't lengthen them right away." The condition in these altered mice bears a close resemblance to dyskeratosis congenita in humans where stem cells in the bone marrow as well as in the intestine are unable to multiply as required and consequently die early.

The details of the study are published in the December 16 issue of the journa l Cell.

The study was funded by the National Institutes of Health and the Johns Hopkins Institute for Cell Engineering. Authors on the paper are Hao, Armanios, Greider, Margaret Strong, Baktiar Karim, David Felser and David Huso, all of Johns Hopkins School of Medicine. Karim and Huso are with the Department of Comparative Medicine.

Contact
Johns Hopkins Medical Institutions
901 S. Bond St., Ste 550
Baltimore, MD 21231
United States
hopkinsmedicine.org/Press_releases
'"/>




Related medicine news :

1. Telomerase Expression Linked To Body Mass
2. Fat Consumption Could Play A Vital Role In Affecting A Child’s Memory
3. Brain Plays Vital Role In Maintaining Bone Density
4. Sex Played A Vital Role For Evolution Of Infectious Diseases
5. Cancer Patient Denied Vital Drug
6. Parental Knowledge Of RSV Infections Is Vital
7. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
8. Aluminium and Iron Could Play a Vital Role in Multiple Sclerosis
9. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
10. Urban Built Environment May Play a Vital Role in Influencing the Body Size
11. Non-Coding RNA Vital For Gene Activation And Protein Expression
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented ... the lowdown on sciatica in a new episode of "Success Files," which is ... events and innovation and investigates each subject in-depth with passion and integrity. , ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... and Consulting, LLC , and named its founder as ... in Tennessee , will operate under ... EnvoyHealth,s service offerings for health care partners to include ... "In an interoperable world, technology delivers ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: