Navigation Links
Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

Carol Greider, Ph.D., director and professor of molecular biology and genetics in the Johns Hopkins Institute of Basic Biomedical Sciences and colleagues have found that the length of telomeres is important// in ensuring that stem cells are able to divide indefinitely.

Telomeres are the ends of the chromosomes that protect genetic information while the chromosome is undergoing division. These are basically "repetitive stretches of DNA" designed to protect chromosomes. Every time a cell undergoes division, the chromosome ends shorten ultimately exposing the genetic information in the stem cell and preventing further division. But a protein called telomerase prevents this from happening and thus cells can divide "n" number of times. In the current study, the Johns Hopkins researchers say that stem cells did not retain their chromosome ends in mice that were engineered to have just half the normal amount of telomerase. "These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents," says Carol Greider. "This phenomenon could complicate the hunt for disease genes." The problem is that offspring inherit diseases through mutations in genes, but even in half-telomerase mice the disease is still present although the genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice develop disease only because their telomeres are short, and having telomerase doesn't lengthen them right away." The condition in these altered mice bears a close resemblance to dyskeratosis congenita in humans where stem cells in the bone marrow as well as in the intestine are unable to multiply as required and consequently die early.

The details of the study are published in the December 16 issue of the journa
'"/>




Page: 1 2

Related medicine news :

1. Telomerase Expression Linked To Body Mass
2. Fat Consumption Could Play A Vital Role In Affecting A Child’s Memory
3. Brain Plays Vital Role In Maintaining Bone Density
4. Sex Played A Vital Role For Evolution Of Infectious Diseases
5. Cancer Patient Denied Vital Drug
6. Parental Knowledge Of RSV Infections Is Vital
7. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
8. Aluminium and Iron Could Play a Vital Role in Multiple Sclerosis
9. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
10. Urban Built Environment May Play a Vital Role in Influencing the Body Size
11. Non-Coding RNA Vital For Gene Activation And Protein Expression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Telomerase Vital Maintaining Ability Stem Cell Multiply

(Date:9/22/2014)... Metformin, a drug commonly used to treat diabetes, may ... (TSH) among patients with an underactive thyroid, a new ... levels may be associated with heart problems and broken ... this study. Among those in the study with ... low levels of thyroid-stimulating hormone per year compared with ...
(Date:9/22/2014)... Medical experts this past weekend gathered ... discuss brain-related diseases facing an aging population, including ... disorders. , Each of the 50 attendees ... memory care community or hospice office. Silverado, with ... hosts the annual event to facilitate the exchange ...
(Date:9/22/2014)... anxiety, excessive perspiration these symptoms are a few ... the body,s heart rate and plays a crucial role ... from Tel Aviv University points to an additional complication ... published in Mammalian Genome , was conducted by ... the Department of Human Molecular Genetics and Biochemistry at ...
(Date:9/22/2014)... leadership of Senators Sherrod Brown (D-Ohio) and Patty ... care services were lauded yesterday by the American ... representing internal medicine and related subspecialties. A ... introducing the Ensuring Access to Primary Care for ... extend current-law payment rates under Medicaid for certain ...
(Date:9/22/2014)... is one of 11 collaborating institutions that have been ... National Science Foundation for a project focused ... include plant symbionts, animal and human pathogens and decomposers ... used in numerous industrial processes and fermentation of foods, ... Symbiotic associations with zygomycetes may have facilitated the origin ...
Breaking Medicine News(10 mins):Health News:Diabetes Drug Metformin May Affect Thyroid in Some Patients 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 3Health News:Lack of thyroid hormone blocks hearing development 2Health News:Broad physician coalition urges Congress to extend Medicaid pay parity 2Health News:Project launched to study evolutionary history of fungi 2Health News:Project launched to study evolutionary history of fungi 3Health News:Project launched to study evolutionary history of fungi 4
... , REDWOOD CITY, Calif., June 2 Integromics, ... RealTime StatMiner(R) and Integromics Biomarker Discovery(TM) (IBD) for ... The resulting platform provides a uniform ... genomics data, and then identify relevant biological processes ...
... ... Isn,t Sexy, LLC announces an initiative to have all dentists screen their patients for both ... ... epidemic proportions in the United States, Snoring Isn,t Sexy, LLC announces an initiative to have ...
... ... HealthForumOnline (HFO), announces a new CE/CEU course entitled A Review ... and Coordination of Care of the Pain Patient to their extensive ... professionals, nurses and allied healthcare workers. While there is an ...
... (NYSE: SGP ) today announced that the ... the company,s Marketing Authorization Application (MAA) for SYCREST(R) (asenapine) ... episodes associated with bipolar I disorder. The application ... The MAA for SYCREST includes data from the asenapine ...
... , LOS ANGELES, June 1 Neurosurgeons, brain tumor researchers ... Department of Neurosurgery will present a one-day conference, ... to 4:30 p.m. The free conference is designed for brain ... the Medical Center,s Harvey Morse Auditorium, 8700 Beverly Blvd., Los ...
... , Support of local communities in the Silicon Valley , ... one of the nation,s first and leading providers of kidney ... announced their participation at the National Kidney Foundation (NKF) walk ... event will be held Saturday, June 6 at Cityview Plaza ...
Cached Medicine News:Health News:Ingenuity and Integromics Offer Integration for Comprehensive Genomics Analysis 2Health News:Founder of Snoring Isn't Sexy, LLC Urges All Dentists to Screen Their Patients for Snoring and Obstructive Sleep Apnea 2Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 2Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 3Health News:HealthForumOnline Offers New Online CE/CEU Course on Pain Screening Instruments for Medical and Mental Health Providers 4Health News:Schering-Plough Announces European Filing of SYCREST(R) (asenapine) for the Treatment of Schizophrenia and Bipolar I Disorder 2Health News:'Outsmarting Brain Tumors': Cedars-Sinai Researchers, Neurosurgeons and Other Experts Present Free Conference for Adult Brain Tumor Patients and Caregivers 2Health News:Satellite Healthcare Steps Out in San Jose 2
(Date:9/22/2014)... Research and Markets has announced ... Hypercholesterolemia Drugs" report to their offering. ... cholesterol burden despite the presence of many cholesterol-lowering drugs ... statins have been ubiquitously prescribed over the last 25 ... cholesterol (LDLC) is the cornerstone of assessing heart risk. ...
(Date:9/22/2014)... 2014 Persistence Market Research ( ... Study on Ophthalmic Devices: Asia ... market was valued at USD 29,171.5 million in 2014 and ... from 2014 to 2020, to reach an estimated value ... the full Global Market Study on Ophthalmic Devices:  Asia ...
(Date:9/22/2014)... Md. , Sept. 22, 2014  Neuralstem, Inc. (NYSE ... MD, site investigator at Emory University, presented long-term follow ... human neural stem cells in the treatment of amyotrophic ... The presentation, which occurred at the Annual Symposium on ... Canada , on Friday, and was not open ...
Breaking Medicine Technology:PCSK9 and Other Novel Hypercholesterolemia Drugs 2PCSK9 and Other Novel Hypercholesterolemia Drugs 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4
... 14, 2011 /PRNewswire-Asia-FirstCall/ -- China Botanic Pharmaceutical Inc. ... Inc.) ("China Botanic" or the "Company"), a developer, ... traditional Chinese medicines ("TCM") in China, today announced ... Enterprise assessment, and that as a result, China ...
... 14, 2011 Reportlinker.com announces that a new ... Global Cardiac Monitoring Systems Market ... With advancements in technology, innovative product offerings ... introduced in the Cardiac Monitoring Systems market. Further, ...
Cached Medicine Technology:China Botanic Pharmaceutical Receives a Tax Exemption in 2011 2China Botanic Pharmaceutical Receives a Tax Exemption in 2011 3Reportlinker Adds Global Cardiac Monitoring Systems Market -2013 2Reportlinker Adds Global Cardiac Monitoring Systems Market -2013 3
... Plate Shaker are designed to give reliable performance ... microplates. The on/off button, power supply socket and ... of the unit. The speed knob is located ... of speed from a minimum 950 rpm to ...
... FACSCalibur is the only four-color, automated benchtop ... analysis and cell sorting. Designed specifically to ... FACSCalibur system offers software instrument control, auto-sample ... ease and productivity. FACSCalibur is fully modular ...
... Compact mobile flow cytometer for ... absolute volumetric counting. The CyFlow SL ... in combination with up to 3 ... real-time display is performed with a ...
The Elecsys 2010 Rack System streamlines processes and allows for smooth implementation of laboratory automation....
Medicine Products: