Navigation Links
Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

Carol Greider, Ph.D., director and professor of molecular biology and genetics in the Johns Hopkins Institute of Basic Biomedical Sciences and colleagues have found that the length of telomeres is important// in ensuring that stem cells are able to divide indefinitely.

Telomeres are the ends of the chromosomes that protect genetic information while the chromosome is undergoing division. These are basically "repetitive stretches of DNA" designed to protect chromosomes. Every time a cell undergoes division, the chromosome ends shorten ultimately exposing the genetic information in the stem cell and preventing further division. But a protein called telomerase prevents this from happening and thus cells can divide "n" number of times. In the current study, the Johns Hopkins researchers say that stem cells did not retain their chromosome ends in mice that were engineered to have just half the normal amount of telomerase. "These offspring have what we have called 'occult' genetic disease -- their genetic make-up is perfectly normal, but they still have the physical problems of their parents," says Carol Greider. "This phenomenon could complicate the hunt for disease genes." The problem is that offspring inherit diseases through mutations in genes, but even in half-telomerase mice the disease is still present although the genetic basis gets obscured due to the inherited telomere length and not the gene. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice develop disease only because their telomeres are short, and having telomerase doesn't lengthen them right away." The condition in these altered mice bears a close resemblance to dyskeratosis congenita in humans where stem cells in the bone marrow as well as in the intestine are unable to multiply as required and consequently die early.

The details of the study are published in the December 16 issue of the journa l Cell.

The study was funded by the National Institutes of Health and the Johns Hopkins Institute for Cell Engineering. Authors on the paper are Hao, Armanios, Greider, Margaret Strong, Baktiar Karim, David Felser and David Huso, all of Johns Hopkins School of Medicine. Karim and Huso are with the Department of Comparative Medicine.

Contact
Johns Hopkins Medical Institutions
901 S. Bond St., Ste 550
Baltimore, MD 21231
United States
hopkinsmedicine.org/Press_releases
'"/>




Related medicine news :

1. Telomerase Expression Linked To Body Mass
2. Fat Consumption Could Play A Vital Role In Affecting A Child’s Memory
3. Brain Plays Vital Role In Maintaining Bone Density
4. Sex Played A Vital Role For Evolution Of Infectious Diseases
5. Cancer Patient Denied Vital Drug
6. Parental Knowledge Of RSV Infections Is Vital
7. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
8. Aluminium and Iron Could Play a Vital Role in Multiple Sclerosis
9. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
10. Urban Built Environment May Play a Vital Role in Influencing the Body Size
11. Non-Coding RNA Vital For Gene Activation And Protein Expression
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can be ... a preset onto their media," said Christina Austin - CEO of Pixel Film Studios. ... quickly and easily add stylish color grades to their footage. A LUT is a ...
(Date:5/27/2016)... CA (PRWEB) , ... May 27, 2016 , ... More ... Health, so it is not surprising that bariatric surgery has received increased attention in ... Journal explains. Of course, when it comes to weight loss, most people are familiar ...
(Date:5/27/2016)... ... ... An influential resource amongst nurses and professionals in the health care world, ... of topics detailing why we appreciate nurses in so many different ways. From exclusive ... being in a major recession to one of the hottest growing professions in any ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response to meager ... are unaware of the plight of aphasia. In collaboration with the American Aphasia ... campaign. , The link between stroke and aphasia is relatively unknown, but through ...
(Date:5/27/2016)... ... May 27, 2016 , ... Each year Standard Process ... Outerbridge is this year’s Life University winner of a $2,500 scholarship ... Student Leadership Awards ceremony. , Outerbridge is approaching her last quarter at Life ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 Digital ... issuance to it by the US Patent and ... company,s technology includes proprietary processes for electronic opt-­in ... health and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows ...
(Date:5/24/2016)... Niederländische Chirurgen haben eine ... Ärzten erlaubt, ihre Expertise weltweit zu teilen und ... Streaming mit einer Instant-Messaging-Funktion und der Möglichkeit, in ... Europa, Afrika, Asien und den USA ... registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... May 24, 2016  Diana Russell suffers from a ... from the inside out.  This disease has put her ... her children and grandchildren to leave her home.  Because ... family cannot haul the wheelchair.  So if there is ... and Diana is left to wait for the bus. ...
Breaking Medicine Technology: