Navigation Links
Tears Reveal Some of Their Deepest Secrets to Researchers

It’s no secret why we shed tears. But exactly what our tears are made of has remained a mystery to scientists.//

A new study sheds some light on the complex design of tears. What we think of as tears, scientists call tear film, which is made up of three distinct, microscopic layers. The middle, watery layer – what we normally think of as tears when we cry – is sandwiched between a layer of mucus and an outer layer of fatty, oily substances collectively called meibum.

It’s in this outer layer that researchers describe, for the first time, a new class of lipids – a type of fat – that make up part of the film. They also identified one of these lipids, oleamide, which had not been known to be a part of tears before.

With each blink, meibum spreads over the surface of the eye. It keeps the watery middle layer in place, ensuring that our eyes stay moist.

Finding these lipids may help scientists better understand the causes of eye-related disorders such as dry eye disease, which affects anywhere from 12 to 14 million Americans, said Kelly Nichols, the study’s lead author and an assistant professor of optometry at Ohio State University.

“The lack of certain compounds in the tear film may result in a number of different eye-related disorders, including dry eye,” she said. “The amount of oleamide and related lipids in tear film may be related to these disorders.”

Dry eye is really a collection of irritating symptoms that includes microscopic damage to the front of the eye. The eyes may ache, burn, feel extremely dry or excessively tear.

The researchers report their findings in the current issue of the journal Investigative Ophthalmology and Visual Science.

They collected oily meibum secretions from the meibomian glands of healthy volunteers. The meibomian glands are tiny, grape-like clusters of cells that line the rim of our upper and lower eyelids – the outlets to these glands are roughly adjacent to the eyelashes. Researchers gently pressed the volunteers’ lower eyelids and collected droplets of meibum in tiny glass tubes.

The researchers examined the meibum samples in the laboratory. They used a technique called electrospray mass spectrometry to differentiate between the different lipid components. This technique adds an electric charge to microscopic droplets of the oily substance, which allows the instrument to detect different components based on electrical charges and mass.

Nichols points out that researchers have used other techniques, such as chromatography, to characterize types of lipids in the tear film, but advances in mass spectrometry technology are improving research efforts.

“Other scientists used different techniques to try to determine the composition of meibum, but mass spectrometry is sensitive enough to detect individual lipid molecules, like oleamide,” Nichols said.

Oleamide was first identified as a lipid in the brain, where one of its roles is to induce sleep. It also has other key functions throughout the central nervous system. But the current study is the first to find and describe oleamide and related lipids in tear film.

“The finding could give us more insight into the role of lipid activity in humans and may also indicate a new function for oleamide and related lipids in cellular signaling in the eye and in the maintenance of tear film,” said Nichols, adding that researchers don’t fully understand the function of oleamide, or the other lipids in the meibum.

“Oleamide appears to be a predominate lipid in tear film,” she said. “It’s there for a reason, but we’re not sure yet what that reason is.”

Nichols and her team are currently studying the role of oleamide in cellular signaling and communication in the eye, along with the role that the lipid may play in dry eye.

“Dry eye is really a disorder of symptoms that irritat e the eyes,” Nichols said. “Not everyone with dry eye responds to the same treatment. If we could find individuals with varying oleamide levels, then we may be able discern one cause of dry eye, and specifically treat that.

“Even though two people with dry eye may have the same symptoms, there may be very different causes underlying those symptoms.”
Source-Newswise
SRM
'"/>




Related medicine news :

1. Girl Complained of Rolling Down Stones Instead of Tears While Crying
2. Methamphetamine Use Increases Risks of Artery Tears and Stroke
3. PET Scans Found To Reveal Hidden Cancers
4. Secret Of Heart Failure Revealed
5. Excavations Reveal Clues Of Early Warfare
6. New Procedure Reveals the Secrets of the Brain
7. Study Reveals Better Results in Patients Suffering From Depression.
8. Designer Rats Reveal Possible Heart Disease Genes
9. Brain Is More Active While Hiding The Truth, Reveals fMRI Imaging
10. Gene Bias: Onomastics of Shared Surnames among Men Reveals Genetic links
11. Revealing Study Results May Do More Harm Than Good
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... ... 2017 , ... Axiad IDS , a leading provider of trusted identities ... the company a “Top 25 Cybersecurity Companies 2017.” Axiad IDS received this ... and proactively address potential cybersecurity threats before they happen. The annual list ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... a 2017 Best in KLAS category winner, has named Daniel P. Bullington as ... and enhance its technology platform and product offerings,” says Justin Neece, president. “Daniel ...
(Date:5/23/2017)... ... May 23, 2017 , ... Drs. Allen Huang and ... in Las Vegas, NV, and the importance of treating it immediately. They ... leading care for peri-implantitis, with or without a referral. As experienced periodontists and ...
(Date:5/23/2017)... ... ... New patients with symptoms of gum disease in San Diego, ... treatments from the doctors at Art of Dentistry, without first receiving a referral. Drs. ... of receiving qualified treatment in order to avoid systemic health effects associated with untreated ...
(Date:5/22/2017)... Mt. Kisco, NY (PRWEB) , ... May 22, 2017 , ... ... are urged to receive relaxing sedation dentistry in Mt. Kisco, NY from Advanced ... can be administered for a variety of treatments. One or more sedation methods may ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO)., has completed its ... health care service center company based in ... relationship management programs for leading pharmaceutical manufacturers and health ... WRB will join Envoy Health Management, LLC , ... biotech firms, and other service companies. Together, WRB and ...
(Date:5/6/2017)... 5, 2017  May is Stroke Awareness Month and ... most important methods to prevent a stroke: monitor and ... Disease Control and Prevention, undetected and uncontrolled hypertension is ... the global leader in personal heart health technology, recently ... heart attack and stroke and is advancing a national ...
(Date:5/4/2017)...  Fortuna Fix Inc. (" Fortuna "), a private, ... eliminate the need for embryonic and fetal stem cells by ... Fortuna announced today the launch of ... , MD, PhD; Father Kevin FitzGerald , S.J., PhD; ... James Giordano , PhD. "We are excited ...
Breaking Medicine Technology: