Navigation Links
Tears Reveal Some of Their Deepest Secrets to Researchers

It’s no secret why we shed tears. But exactly what our tears are made of has remained a mystery to scientists.//

A new study sheds some light on the complex design of tears. What we think of as tears, scientists call tear film, which is made up of three distinct, microscopic layers. The middle, watery layer – what we normally think of as tears when we cry – is sandwiched between a layer of mucus and an outer layer of fatty, oily substances collectively called meibum.

It’s in this outer layer that researchers describe, for the first time, a new class of lipids – a type of fat – that make up part of the film. They also identified one of these lipids, oleamide, which had not been known to be a part of tears before.

With each blink, meibum spreads over the surface of the eye. It keeps the watery middle layer in place, ensuring that our eyes stay moist.

Finding these lipids may help scientists better understand the causes of eye-related disorders such as dry eye disease, which affects anywhere from 12 to 14 million Americans, said Kelly Nichols, the study’s lead author and an assistant professor of optometry at Ohio State University.

“The lack of certain compounds in the tear film may result in a number of different eye-related disorders, including dry eye,” she said. “The amount of oleamide and related lipids in tear film may be related to these disorders.”

Dry eye is really a collection of irritating symptoms that includes microscopic damage to the front of the eye. The eyes may ache, burn, feel extremely dry or excessively tear.

The researchers report their findings in the current issue of the journal Investigative Ophthalmology and Visual Science.

They collected oily meibum secretions from the meibomian glands of healthy volunteers. The meibomian glands are tiny, grape-like clusters of cells that line the rim of our upper and lower eyelids – the outlets to these glands are roughly adjacent to the eyelashes. Researchers gently pressed the volunteers’ lower eyelids and collected droplets of meibum in tiny glass tubes.

The researchers examined the meibum samples in the laboratory. They used a technique called electrospray mass spectrometry to differentiate between the different lipid components. This technique adds an electric charge to microscopic droplets of the oily substance, which allows the instrument to detect different components based on electrical charges and mass.

Nichols points out that researchers have used other techniques, such as chromatography, to characterize types of lipids in the tear film, but advances in mass spectrometry technology are improving research efforts.

“Other scientists used different techniques to try to determine the composition of meibum, but mass spectrometry is sensitive enough to detect individual lipid molecules, like oleamide,” Nichols said.

Oleamide was first identified as a lipid in the brain, where one of its roles is to induce sleep. It also has other key functions throughout the central nervous system. But the current study is the first to find and describe oleamide and related lipids in tear film.

“The finding could give us more insight into the role of lipid activity in humans and may also indicate a new function for oleamide and related lipids in cellular signaling in the eye and in the maintenance of tear film,” said Nichols, adding that researchers don’t fully understand the function of oleamide, or the other lipids in the meibum.

“Oleamide appears to be a predominate lipid in tear film,” she said. “It’s there for a reason, but we’re not sure yet what that reason is.”

Nichols and her team are currently studying the role of oleamide in cellular signaling and communication in the eye, along with the role that the lipid may play in dry eye.

“Dry eye is really a disorder of symptoms that irritat e the eyes,” Nichols said. “Not everyone with dry eye responds to the same treatment. If we could find individuals with varying oleamide levels, then we may be able discern one cause of dry eye, and specifically treat that.

“Even though two people with dry eye may have the same symptoms, there may be very different causes underlying those symptoms.”
Source-Newswise
SRM
'"/>




Related medicine news :

1. Girl Complained of Rolling Down Stones Instead of Tears While Crying
2. Methamphetamine Use Increases Risks of Artery Tears and Stroke
3. PET Scans Found To Reveal Hidden Cancers
4. Secret Of Heart Failure Revealed
5. Excavations Reveal Clues Of Early Warfare
6. New Procedure Reveals the Secrets of the Brain
7. Study Reveals Better Results in Patients Suffering From Depression.
8. Designer Rats Reveal Possible Heart Disease Genes
9. Brain Is More Active While Hiding The Truth, Reveals fMRI Imaging
10. Gene Bias: Onomastics of Shared Surnames among Men Reveals Genetic links
11. Revealing Study Results May Do More Harm Than Good
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 ... ... Company, Cal Dining at the University of California Berkeley, and other leading institutions ... leverages the buying power of institutions to change the way animals are raised ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... that its MyDario product is expected to appear on The Dr. Oz ... Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked ... The segment features ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
Breaking Medicine Technology: