Navigation Links
Team Tracks Genetic Origins of Eye Cancer

A West Virginia University professor and two alumni have tracked the chromosomal abnormalities associated with a tumor that develops in the eye and often leads to blindness and death.// They're hopeful their findings could someday lead to improved treatment for those who suffer from it.

Joginder Nath, professor of genetics and developmental biology, and former doctoral students Jason White ('02) and Alison Director-Myska ('96) published their findings in two recent issues of Cancer Genetics and Cytogenetics.

The first paper, published in July, describes the specific differences in chromosomal material in cell lines established from sample tissue of these tumors. The second, published in the October issue, describes similar anomalies observed in nearly 100 patients.

Both articles reflect research that comprised a large part of White's doctoral research at WVU. Much of the research was conducted at the Armed Forces Institute of Pathology in Rockville, Md., where Director-Myska headed a lab studying chromosomal aberrations.

"Uveal melanoma develops within the eye, and it's commonly detected when vision begins to be affected," White explained. "By this time, the tumor has grown quite large, and it then migrates to the liver. Once this has occurred, the prognosis is quite poor."

Treatment is often aggressive, involving removal of the eye, though more conservative alternatives are being explored and developed.

The WVU team studied these tumors at the chromosomal level. They studied cell lines from tumor tissue samples, and found common rearrangements in chromosomal configurations.

White found these rearrangements using three different techniques: fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and spectral karyotyping (SKY). FISH involves the fluorescent labeling of a piece of DNA to determine where that piece of DNA is found and how many copies there are . CGH is essentially an expanded version of FISH, with entire tumor cell lines, or genomes, labeled in different fluorescent colors, that provides a genome-wide comparison of amplified and deleted regions in DNA. SKY allows the researcher to track the physical rearrangement of chromosomes in a tumor cell, thereby revealing the origins of extra and deleted chromosomal material.

"This research was undertaken with the hope that identification of regions and genes of importance in this disease could lead to improvements in treatment strategies," said Nath, who directs WVU’s interdisciplinary graduate programs in genetics and developmental biology. Nath's research has focused on cytogenetics, the study of chromosomes, throughout his 40-year career.

"While gene therapy has enjoyed limited success to date, knowing the genetic make-up of a given tumor can guide the oncologist toward choosing an appropriate treatment regimen," White explained. "Ideally, this will lead to more preservative therapies, and fewer patients with uveal melanoma will have to endure the loss of their eye."

Source-Newswise
'"/>




Related medicine news :

1. Stop HIV/AIDS in its Tracks with Education
2. CDC Study Tracks Levels of Heart Diseases Across the U.S.
3. New Imaging Technique Tracks Traffic Patterns of White Blood Cells
4. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
5. Genetic influence in menopause
6. Genetics and cholesterol levels
7. Genetics helps in attacking cancer
8. Genetic disorder related with sleep patterns
9. Genetic innovation
10. Genetic tests for cancer
11. Genetic indicates memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... 08, 2016 , ... Remember the old saying “rub some dirt on it”? ... author of “Calcium Bentonite Clay” the health benefits of integrating clay into a daily ... body. , A former motivational speaker, Perry A~ has since dedicated her life to ...
(Date:2/8/2016)... ... 08, 2016 , ... GrassrootsHealth published data from its D*action ... diabetes in the GrassrootsHealth cohort with substantially higher vitamin D levels than a ... health,” states Carole Baggerly, Director of GrassrootsHealth, “the safety and benefits of ...
(Date:2/8/2016)... NV (PRWEB) , ... February 08, 2016 , ... Guruji ... February 9th, 10th and 11th, 2016 in honor of his birthday on February 10th. ... true happiness. Mahendra Trivedi is known by over 250,000 people from over 40 ...
(Date:2/7/2016)... (PRWEB) , ... February 07, 2016 , ... Women's Excellence ... National Wear Red Day. National Wear Red Day is the first Friday each ... Heart disease and stroke cause 1 in 3 deaths among women each year – ...
(Date:2/6/2016)... CA (PRWEB) , ... February 06, 2016 , ... US ... Ultimate Coaching Conference (YUCC) . This event brings together top non-profit leaders, ultimate organizations, ... Equity and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 5, 2016  Despite the recent explosion in Big ... industries to embrace Big Data due to the inherent ... medical side, organizations have begun looking to Big Data ... to adherence. --> --> ... Practices, LLC, Big Data has started informing many decisions. ...
(Date:2/5/2016)... , Feb. 5, 2016  Redwood Scientific Technologies, Inc. ... product designed to help women balance their hormones. This ... technology. Jason Cardiff , President and ... able to help the millions of women across the ... effects of imbalanced hormones. Our research and development team ...
(Date:2/5/2016)... 5, 2016  ivWatch, a medical devices company, is one ... granted by Governor Terry McAuliffe,s office. ivWatch will ... 25th at an event to be held at the Science ... honors professionals and business that have made significant contributions to ... - http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
Breaking Medicine Technology: