Navigation Links
Team Discovers a Gene That Causes Familial Pancreatic Cancer

An international group of researchers has discovered that the mutated form of a gene called Palladin causes familial pancreatic cancer. The findings may help explain why the// disease is so deadly. The research project was led by Dr. Teri Brentnall, University of Washington associate professor of medicine, and supported by The Lustgarten Foundation, Canary Foundation, and other private sources.

Pancreatic cancer is usually a fatal diagnosis. One of the deadliest types of cancer, it is the fourth leading cause of cancer deaths overall, and third-leading cause of cancer deaths for people aged 40 to 60 in the United States. Most people with the disease die within a year of diagnosis; about 95 percent of patients die within five years. Researchers estimate that at least ten percent of all pancreatic cancer cases are inherited.

The discovery also reveals that the Palladin gene behaves abnormally in both the hereditary and non-hereditary, or sporadic, forms of pancreatic cancer. Previous studies by co-author Dr. Carol Otey, associate professor of physiology at the University of North Carolina, have revealed that when the Palladin gene is functioning properly, it gives a cell its shape and enables the cell to move. In the case of pancreatic cancer, a mutation in Palladin allows the cell to move much more quickly than normal, essentially invading the surrounding, healthy tissue.

Palladin, identified six years ago by Otey, is involved in the cytoskeleton, the structural backbone of all human cells. Brentnall discovered that Palladin played a role in pancreatic cancer and began to collaborate with Otey. The team believes that the mutated Palladin causes cancer by causing the cytoskeleton to malfunction, which allowed the cells to move much more quickly than normal cells.

“A normal cytoskeleton holds up the cell wall, and gives it direction to sit down in its proper place and basically to behave,” said Brentnall. “In cancerous cells, the cytoskeleton doesn't work correctly, and instead of sitting, the cells get up and invade areas where they don't belong, which is how the cancer spreads. This is a new way of thinking about cancer development in the pancreas.”

“Brentnall and her colleagues' report of their fascinating discovery of a new cause of inherited pancreatic cancer provides us with important new insights into the mechanisms of pancreatic cancer development that will have a significant impact on future research,” said Michael Goggins, MD, Associate Professor of Pathology, Medicine and Oncology at The Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins.

Brentnall began her search for the pancreatic cancer gene in 1996 when one of her patients described his family’s “curse.” His grandfather, father, four uncles and three cousins had all died of pancreatic cancer, some at a very young age. Brentnall designated this family as “Family X” and set off to identify the source of the fatal inheritance. The puzzle took a decade to unravel.

Brentnall and her colleagues developed a surveillance program for the early detection of pancreatic pre-cancer in families who inherit the disease. “By performing surveillance on many of the Family X members, the research team identified which ones had the initial stages of pancreatic cancer” said Brentnall. “We then compared DNA samples from the family members with pre-cancer to those who did not have the disease, and isolated the cancer-causing gene to an area of Chromosome 4.”

Over the next two years, the researchers, led by Dr. Kay Pogue-Geile, associate professor of research at University of Pittsburgh School of Medicine, created a customized DNA microarray to help them isolate the gene responsible. They searched for the genes most abnormally expressed in that area on Chromosome 4, using pre-cancerous tissue from Family X pancreas and from 10 sporadic pancreatic cancers, comparing the results t o normal pancreas tissue. The scientists hoped this approach would help them find the genes that were over-expressed in abnormal pre-cancerous and cancerous tissue.

“We finally found what we had so doggedly pursued -- a gene that was expressed 21 times more than any other,” said Brentnall. “This gene, Palladin, was mutated in Family X and appeared to cause the fatal inheritance. Every one of the members of Family X who had the Palladin mutation got pancreatic cancer or pre-cancer, while the members of Family X who did not have the mutation were cancer-free.”

By understanding the genes that cause pancreatic cancer in families, scientists can better understand why the disease forms sporadically in the general population. When Brentnall and her colleagues examined pancreas cells from cancer patients with no family history, they found that Palladin was also over-expressed in those cells. In fact, they found that in these non-hereditary cases, the gene became increasingly over-expressed as the pancreas tissue progressed through the pre-cancer stage and then to cancer.

Testing for a Palladin gene mutation may be possible in families that inherit pancreatic cancer (two or more affected family members). However, genetic testing is not likely to be useful for non-hereditary or sporadic pancreatic cancer (only one person affected in a family). Brentnall and her team hope to develop a screening blood test for pancreatic cancer using the Palladin protein, as well as treatments that target mutations in Palladin. In addition, early indications show that the study of Palladin may also shed light on how and why other cancers spread as well.

Soure-Newswise
SRM
'"/>




Related medicine news :

1. Studies On Hearing Loss Discovers New Causes
2. Indian Researcher Discovers Reason For Malignancy of Skin Cancer
3. Haryana Government Discovers Misappropriation In School Funds
4. Scientist Discovers Crucial Part of Blood-Clotting Process
5. Researcher Discovers Target Site for Developing Mosquito Pesticides
6. Mayo Researcher Discovers Target Site for Developing Mosquito Pesticides
7. Researchers Discovers DNA Repair as Key to Huntingtons Disease
8. Breast Cancer Surgery Causes Psychological problems
9. Causes of weakness in the aged
10. Gene Mutation Causes Ovarian Failure
11. Studying The Causes Of Autism
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
Breaking Medicine Technology: