Navigation Links
Targeting the Adrenal Gland Could Be Key Against Heart Failure

Scientists have staved off heart failure in animals by using gene therapy to shut down the adrenal gland’s excessive// output of fight or flight hormones such as epinephrine and norepinephrine. By blocking GRK2, an important regulatory enzyme, they cut the hormone production that forces the heart to pump too hard, leading to heart failure. Such a novel approach – targeting the adrenal gland in addition to the heart – provides a potential new strategy against heart failure, and could lead to a new class of drugs.

The researchers, led by Walter Koch, Ph.D., W.W. Smith Professor of Medicine and director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College, report their findings in the journal Nature Medicine.

“The emphasis has always been in treating right at the heart,” says Stephen B. Liggett, M.D., director of the cardiopulmonary genomics program at the University of Maryland School of Medicine, who has written an accompanying editorial.

“Despite our best efforts, about half of all heart failure patients die within five years of diagnosis, so clearly something new is needed. These results add a completely new dimension to the way physicians might be able to intervene to improve heart failure therapy.”

When an individual’s heart begins to fail, the sympathetic nervous system, attempting to compensate for the weakened heart, goes into overdrive, pumping out increasing levels of stimulants – catecholamines such as epinephrine and norepinephrine, making a bad situation worse. The typical treatment – beta blockers – inhibit the beta adrenergic receptors on the heart, blocking the hormones that force the heart to work overtime.

Dr. Koch’s group focused instead on the source of catecholamines – the adrenal gland. It discovered that in heart failure, the extra hormones “desensitize” the adrenal’s alpha 2 adrenergic receptors because of a rise in GRK2, or G protein-cou pled receptor kinase 2, essentially turning them off. Using gene therapy to block adrenal gland GRK2 in animals in heart failure, the scientists were able to get the alpha 2 receptors working again and also found that the beta adrenergic receptors on the heart worked better as well.

“We’ve shown that in the adrenal gland, resetting the alpha adrenergic receptors by inhibiting GRK2 causes more normal regulation and the proper feedback control, and catecholamines are lowered,” explains Dr. Koch, who also heads the George Zallie and Family Laboratory of Cardiovascular Gene Therapy in the Department of Medicine. “If less catecholamine is presented to the heart, then the beta receptors restabilize and that improves heart function. The heart is allowed to relax and get better.”

“This is the first time anyone has identified a molecular mechanism involved in such sympathetic overdrive in heart failure,” adds study first author Anastasios Lymperopoulos, Ph.D., a postdoctoral fellow in the Center for Translational Medicine, and means that adrenal gland GRK2 becomes a new target for heart failure medications.

“GRK2 inhibitors would be a totally new class of drugs if they come on the market,” Dr. Koch says, adding that eventually, human gene therapy for heart failure could be feasible.
Source-Newswise
SRM
'"/>




Related medicine news :

1. Novel Technique For Targeting Small-Cell Lung Cancer
2. Targeting PARP1 Is Effective In Protecting HD Cells from Damage
3. Ad Campaign Targeting Republicans On Medicare Prescription Drug Program
4. By Targeting Specific Germs, Hospital Hopes to Improve Pneumonia Treatment
5. Highly Potent TB Strain Plays Favorites Targeting Specific Ethnic Groups
6. New Asthma Medicine Targeting Vulnerable Inner-City Children Tested
7. Targeting a Single Gene Could Inhibit Bone Decay and Stimulate Bone Growth
8. Researchers Find Stem-cell Therapy Effective in Targeting Metastatic Cancer
9. Targeting SOCS-3 can Control Obesity
10. Sex Abstinence Programs Targeting School-goers may Not Produce Desired Effect , Study
11. Adrenal Suppression not predicted by inhaled corticosteroids
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... Texas (PRWEB) , ... May 26, 2016 , ... ... Friday, May 13 at Blackhorse Golf Club in Cypress. With the help of community ... non-profit that restores, empowers, and renews hope for wounded service members and their families ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... and products recently hosted the first PowerWave Instructor Certification Course in Stoughton, Massachusetts. ... a group of fitness professional through the 8 hour interactive course to qualify ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our professional athletes coincides ... HEAD ™”. , “We are proud to introduce Meghan Klingenberg, defender and ... have Brian Quick, wide receiver for Los Angeles who was a second round selection ...
(Date:5/26/2016)... ... ... Dr. LeRoy Perry’s recently authored whitepaper, “Tech Neck and ROI (return on ... users, hundreds of millions of whom are coming into the workplace with pain in ... action of looking down at hand-held technology devices (tablets, smartphones) for extended periods of ...
(Date:5/26/2016)... ... ... In Madeira Beach Florida, a small town with 4,300 residents on a ... Madeira Beach United, to oppose two development projects undertaken by their city government that ... rise urban environment. , According to the Tampa Bay Times on May ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016  Joe Marziani has joined VMS BioMarketing as senior vice president of sales, ... his new role, Marziani will lead the company,s business development and sales team, exploring ... Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... May 24, 2016 ... , la première endoprothèse à double ... à l,intervention portant sur les membres inférieurs ... OrbusNeich, entreprise mondiale spécialisée dans la ... la vie, a élargi son portefeuille pour ...
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
Breaking Medicine Technology: