Navigation Links
Targeting SOCS-3 can Control Obesity

A new research demonstrates how obesity causes the breakdown of a brain system that regulates appetite. The study also points// to a key gene as a possible target for new drug therapies to help individuals lose weight.

More than 60 percent of American adults are overweight and around 30 percent are obese. The study conducted by scientists at the Oregon National Primate Research Center is published in the March issue of Cell Metabolism.

The research provides new understanding of leptin resistance. Leptin is a hormone secreted by fat cells. It can suppress food intake by affecting brain cells that control appetite. However, high levels of leptin which can be found in severely overweight individuals, can lead to leptin resistance. Leptin resistance means that the body no longer responds to the hormone's weight suppressing effects.

The research was conducted in mice and involved two separate groups that were fed high-fat and low-fat diets. Over time, the high-fat diet group developed symptoms of diabetes and obesity, as is often the case in humans. The low-fat diet group did not develop these health problems.

"This research demonstrates how a portion of the hypothalamus of the brain, called the arcuate nucleus, is negatively impacted by an overabundance of leptin," explained Michael Cowley, Ph.D., an associate scientist in the Division of Neuroscience at ONPRC. "By developing a special test of neuronal function, we were able to witness the breakdown in this group of specialized cells.

Eventually the cells behaved as if there was no leptin present, even though levels were 40-times higher than in normal animals. We were also able to witness the eventual repair of this important system which occurs as the mice lost weight when returned to a low fat diet."

More specifically, the scientists determined that leptin resistance prevented the arcuate nucleus from taking part in an important signaling functio n that regulates appetite and body weight. Meanwhile, other portions of the weight regulation system remained intact and in fact became more responsive, thereby suggesting that arcuate nucleus function is the point of breakdown during leptin deficiency.

Finally the research highlighted a key gene called SOCS-3 involved in leptin deficiency. By targeting the gene with therapeutics, scientists may be able to repair leptin deficiency, aiding in weight loss.

"Of course these findings are quite far from the development of a weight loss drug," explained Cowley. "This work further highlights the essential role of SOCS-3 in this critical regulation system."

"One of the surprising things was when we put the genetically identical mice on the high fat diet, some became obese, and some did not. One major difference between these groups of mice was the activity of SOCS-3," said Pablo Enriori Ph.D. of Cowley's lab, first author of the paper. The research was conducted in conjunction with Brown University in Rhode Island.

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Novel Technique For Targeting Small-Cell Lung Cancer
2. Targeting PARP1 Is Effective In Protecting HD Cells from Damage
3. Ad Campaign Targeting Republicans On Medicare Prescription Drug Program
4. By Targeting Specific Germs, Hospital Hopes to Improve Pneumonia Treatment
5. Highly Potent TB Strain Plays Favorites Targeting Specific Ethnic Groups
6. New Asthma Medicine Targeting Vulnerable Inner-City Children Tested
7. Targeting a Single Gene Could Inhibit Bone Decay and Stimulate Bone Growth
8. Researchers Find Stem-cell Therapy Effective in Targeting Metastatic Cancer
9. Targeting the Adrenal Gland Could Be Key Against Heart Failure
10. Sex Abstinence Programs Targeting School-goers may Not Produce Desired Effect , Study
11. FDA Approves Birth Control Skin Patch
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... The old expression “a ... problem. A common injury that’s often misunderstood, whiplash should be swiftly diagnosed and treated ... orthopedic spine surgeon at Atlantic Spine Center . , So named because ...
(Date:5/24/2016)... ... 24, 2016 , ... Researchers from Catholic Health Initiatives (CHI) ... bleeding complications from percutaneous coronary intervention (PCI). The data, presented at the annual ... document a 40% reduction in risk-adjusted bleeding event rates over a two-year period ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... web-based software module. The cutting-edge feature provides end users with an embedded, ... self-service business intelligence solution and its analytics engine. , This powerful ...
(Date:5/23/2016)... Akron, Ohio (PRWEB) , ... May 23, 2016 ... ... not-for-profit continuing care retirement community, dedicated its new $11.5 million, 64-room assisted living ... an invitation-only ceremony and ribbon cutting. , The new building provides the ...
(Date:5/23/2016)... ... May 23, 2016 , ... According to an article ... than 1% of United Kingdom residents who could benefit from bariatric surgery are actually ... increases the number of bariatric procedures it offers to obese patients from 6,000 to ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... 19, 2016 A new report ... Market -Opportunities and Forecasts, 2015 -2022, projects that the ... 2022, registering a CAGR of 5.1% from 2015 to ... be the highest revenue-generating segment throughout the forecast period. ... one-third of the market share in 2015, and is ...
(Date:5/19/2016)... -- The equities market is never short of ... is without doubt the Healthcare space. ActiveWallSt.com has uncovered four ... Alkermes PLC (NASDAQ: ALKS ), AMAG Pharmaceuticals Inc. ... IDXX ), and Atossa Genetics Inc. (NASDAQ: ... http://www.activewallst.com/ On Wednesday, Alkermes PLC,s ...
(Date:5/19/2016)... 19, 2016 MGB Biopharma, ... of Anti-infectives, Welcomes the Final Instalment of Lord ... Today   Lord Jim O,Neill,s ... final recommendations, providing a comprehensive action plan for ... the rising threat of superbugs - something that ...
Breaking Medicine Technology: