Navigation Links
Tamoxifen does not adversely affect the brain

The breast cancer drug tamoxifen does not damage the brains of elderly women, alleviating fears of a neurotoxic effect of such treatment, recent study has revealed. According to researchers, tamoxifen has a similar effect on the brain to oestrogen, which has been linked with potentially neuroprotective action //against cognitive decline.

The researchers used proton magnetic resonance spectroscopy to determine levels of the cerebral metabolite myo-inositol, which has been found at elevated levels during brain injury, in the brains of 80 women. Sixteen of the women were breast cancer patients who had received tamoxifen therapy for at least two years beforehand, 27 were healthy women who had received preventative oestrogen-based hormone replacement therapy (HRT) for at least two years and 33 were healthy women who had received neither tamoxifen nor HRT.

Dr Ernst and colleagues found that women who had received tamoxifen or oestrogen had lower levels of myo-inositol than the controls who had received neither treatment. The women who had received tamoxifen for the longest period of time had the lowest levels of the metabolite present in their brains.

The researchers concluded that both tamoxifen and oestrogen may have neuroprotective effects, and may modulate the effect on the brain. They added that further research is needed to determine the effects of oestrogen and tamoxifen on cognition.
'"/>




Page: 1

Related medicine news :

1. Letrozole Beats Tamoxifen in Breast Cancer Therapy
2. Tamoxifen reduces breast cancer risk
3. Tamoxifen reduces breast cancer risk
4. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
5. Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer
6. New Drug More Effective than Tamoxifen in Preventing Breast Cancer Relapse
7. Raloxifene Better Than Tamoxifen For Breast Cancer
8. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
9. Study Identifies Mechanism Which May Help Tamoxifen Work Better
10. Tamoxifen Discontinuation Rates Surprisingly High
11. Tamoxifen Yields Long-term Reduction in Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... 2016 According to a new ... Pen Needles, Safety Pen Needles), Needle Length (4mm, 5mm, ... Mode of Purchase (Retail, Non-Retail) - Trends & Global ... the market for the forecast period of 2016 to ... Billion by 2021 from USD 1.65 Billion in 2016, ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: