Navigation Links
Tamoxifen Ineffective In Presence Of Genetic Variation in Breast Cancer

Researchers at the University of Michigan and the Mayo Clinic say that the flagship breast cancer drug, tamoxifen might not be very effective in women who inherit a common genetic variation. //

This particular variant gene has the ability to influence the levels of a crucial enzyme that is vital to activate tamoxifen against breast cancer. The study which was conducted by James Rae, Ph.D., at the University of Michigan Comprehensive Cancer Center and Matthew Goetz, M.D., an oncologist at the Mayo Clinic, found that women who carried a variant of this gene had low levels of the CYP2D6 enzyme. This in turn predisposed for a relapse of the breast cancer. CYP2D6 enzyme is responsible for the metabolization of tamoxifen and plays a crucial role in triggering off the drug's activity against the cancer cells. The UM researchers were also a part of the team that found the adverse affect of the antidepressant drug Paxil on tamoxifen. In the present study, the researchers looked at the enzymatic profile of 256 women with breast cancer. They also found that women who carry the genetic variant do not have intense hot flashes. The researches added that additional tests are needed to confirm these variations, but are hopeful of a clinical test to determine which women can reap the maximum benefit from tamoxifen. "Our group has shown that CYP2D6 is responsible for activating tamoxifen to a metabolite called endoxifen that is nearly 100 times more potent as an anti-estrogen than tamoxifen itself,” said lead researcher Dr Rae. 'Our study suggests that women who inherit a genetic variant in the CYP2D6 gene appear to be at higher risk of relapse when treated with five years of tamoxifen.'

The study is detailed in the December 20 issue of The Journal of Clinical Oncology.
'"/>




Page: 1

Related medicine news :

1. Letrozole Beats Tamoxifen in Breast Cancer Therapy
2. Tamoxifen does not adversely affect the brain
3. Tamoxifen reduces breast cancer risk
4. Tamoxifen reduces breast cancer risk
5. Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence
6. New Drug More Effective than Tamoxifen in Preventing Breast Cancer Relapse
7. Raloxifene Better Than Tamoxifen For Breast Cancer
8. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
9. Study Identifies Mechanism Which May Help Tamoxifen Work Better
10. Tamoxifen Discontinuation Rates Surprisingly High
11. Tamoxifen Yields Long-term Reduction in Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... 02, 2016 , ... Two years ago, Arizona State University ... live by 1 million viewers and won numerous honors, including the region’s top ... the Walter Cronkite School of Journalism and Mass Communication are following up their ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... the launch of its 60-day free trial program for all of the company’s ... the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers use ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... of two ostomy patients, standing as living proof that attitude and determination can ... diseases and issues that spike around the holidays. This campaign will offer patients ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd Regional Conference will ... Spa in Honolulu, offering local frontline clinicians the opportunity to extend their certified ... demand for supplemental training related to pain management has surged dramatically in recent ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... "Pro3rd Accents ... FCPX editors to create versatile lower third titles with just a few clicks of ... Accents Volume 2 includes 30 lower third animations. Choose from various styles with accented ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... ALEXANDRIA, Va. , Dec. 2, 2016 /PRNewswire-USNewswire/ ... year by the Academy of Managed Care Pharmacy ... care organizations can better address the opioid addiction ... Medication Assisted Therapies (MAT). ATAG,s newly ... in Improving Access to Naloxone," addresses many issues ...
(Date:12/2/2016)... 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today announced ... ("PSI").  The combination of Texas -based Maxor ... PSI bring together both company,s clinical expertise and high-touch patient ... industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... , Dec. 2, 2016 CVS Health Corporation ... Analyst Day in New York City on Thursday, December 15, 2016, beginning ... leadership team will provide an in-depth review of the ... value. The company will also discuss 2017 earnings guidance ... webcast of the event will be broadcast simultaneously on ...
Breaking Medicine Technology: