Navigation Links
Synthetic protein found to relieve arthritis symptoms in animal model

A synthetic version of a human protein has been found to alleviate symptoms associated with acute and chronic arthritis in mice, which could be the basis for developing a new drug for the disease, according to researchers. // The protein has been found to function by blocking the transmission of chemical signals associated with development of arthritis symptoms.

The idea that the protein, called pre-ligand assembly domain protein or PLAD, might play a role in easing or comforting pain characteristic of rheumatoid arthritis is an incidental discovery. The original work was carried out on a very rare autoimmune disease called autoimmune lymphoproliferative syndrome (ALPS).

Previously, it has been shown that PLAD blocks a cell surface receptor and prevents a needed chemical signaling pathway from functioning correctly. In ALPS, the signal pathway interrupted by PLAD leads to disease symptoms. But, the scientists reasoned, PLAD might also be able to block a related cell surface receptor one involved in passing signals, leading to inflammation. In theory, inhibiting this pathway might benefit people with rheumatoid arthritis, who suffer from excessive inflammation.

The scientists used a variety of techniques to induce arthritis symptoms in mice. Researchers also injected some of the animals with lab-made PLAD (P60 PLAD). It was found that P60 PLAD protein powerfully inhibited the symptoms of TNF-alpha-induced arthritis (a key promoter of inflammation is a chemical called tumor necrosis factor alpha- TNF-alpha). Moreover, it also appeared to inhibit disease symptoms in mice with established as well as acute arthritis. The scientists did not detect any obvious toxicity in the PLAD-treated mice.

The scientist’s next aim is to develop a more stable form of P60 PLAD to be followed by testing of the protein in clinical trials. This study opens a new research avenue to better understand and, perhaps, to treat rheumatoid arthritis, according to those who believe that a treatment for rheumatoid arthritis is not far way.

Related medicine news :

1. New Study Will The Look Into The Effects Of Synthetic Steroids
2. Synthetic Bone Tissue Could Be the Answer to Disfigurement Caused by Oral Cancer
3. A Synthetic Molecule Instigates Cancer Cells To Self-Harm
4. Synthetic DNA Makes Better Hydrogels for Drug Delivery
5. Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer
6. Synthetic Chemicals May Trigger Breast Cancer
7. Synthetic Cannabinoid Could Improve Fertility in Smokers
8. Chemicals Used To Make Synthetic Color Can Cause Cancer And Permanent Blindness
9. Special proteins to fight TB identified
10. High-protein diets may pose health risks
11. Hidden influenza virus protein found
Post Your Comments:

(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... a safe and convenient way to dispense prescription medications at home, so he ... effective way to monitor and dispense prescription medications. In doing so, it could ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion is ... Pro X. With ProSidebar: Fasion, video editors can easily add an informative sidebar ... minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and text ...
(Date:11/27/2015)... ... , ... A simply groundbreaking television series, "Voices in America", which is hosted ... array of issues that are presently affecting Americans. Dedicated to providing the world with ... changing the subjects consumers focus on, one episode at a time. , In ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... successful and prominent nonprofit healthcare organizations in the country. They have overseen financial ... organizations, and helped advance the healthcare industry as a whole through their advocacy ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... ... substance abuse located in central Michigan, have come together on Thanksgiving Day to ... produced video, available for viewing on the Serenity Point YouTube channel, patients displayed ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... total global healthcare industry is expected to grow at a ... has the highest projected growth at 12.7%, and ... ), is second with growth projected at 11.5%. ... In 2013-2014, total government funded healthcare was nearly 68%. Federal ... in 2013-2014. In real terms, out of pocket expenditure increased ...
(Date:11/25/2015)... , Nov. 25, 2015  The American Academy ... Gynecologists (ACOG), and the March of Dimes cheered ... Protecting Our Infants Act of 2015 (S.799), ... of newborns born exposed to drugs, such as ... bill,s introduction, all three organizations have worked together ...
(Date:11/25/2015)... , Nov. 25, 2015 AAIPharma ... planned investment of at least $15.8  Million to ... Wilmington, NC . The expansion will ... to meet the growing demands of the pharmaceutical ... site expansion will provide up to 40,000 ...
Breaking Medicine Technology: