Navigation Links
Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer

Switching off a mammalian protein called Rad9 could hold the key to killing cancer cells easily with ionizing radiation, according to new research at Washington University School of Medicine in St. Louis. Rad9 was previously thought // to be a "watchman" for DNA, but it is now fund to be a "repairman" for DNA that fixes any breaks in the master molecule.

That is why reserachers are now looking at Rad9 with renewed interest. Turning off the protein could make the radiation treatments more effective, the reserachers say in the study, which appears online in the journal Molecular and Cellular Biology. "Our study suggests that if we could inactivate Rad9 in tumor cells, we would be able to kill them with a very low dose of radiation and gain a therapeutic advantage," observed lead author Tej K. Pandita, Ph.D., associate professor of radiation oncology and on the faculty of the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. The study found that Rad9 proteins interact with telomeres in the chromosomes. These telomeres are special structures located at the ends of chromosomes and protect them from fusion or degradation. "We saw that Rad9 stabilizes telomeres, and because we aren't yet sure how it does it, we will continue to study how Rad9 influences the telomere structure," Pandita said. "We speculate that without Rad9, some of the other proteins associated with the telomeric structure become delocalized, exposing the DNA at the ends of chromosomes." The reserachers are also looking at ways to identify people with mutations in Rad9, since they definitely expose people to the risk of developing cancer, "If Rad9 isn't functioning properly in cells, it can lead to genomic instability and result in the malignant transformation of cells," Pandita commented. "In fact, fusions at the telomeric ends of chromosomes like those seen in the absence of Rad9 appear frequently in tumor tissues." Main Article: Pandita RK, Sha rma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase specific cell survival and homologous recombinational repair. Molecular and Cellular Biology March 2006;26(5):1850-1864.
'"/>




Related medicine news :

1. Switching drugs regularly improves HIV treatment
2. Switching Genes to Overdrive Improves Muscular Dystrophy Symptoms in Mice
3. Lean Protein Could Be Key to Obesity Drugs
4. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
6. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
7. Protein in urine foresees heart disease
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Protein signals need for heart surgery
10. Protein and fat improve memory
11. Clotting Protein plays a role in nerve repair
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... The American Board of Family Medicine's (ABFM) Board of Directors has ... succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in the ... at the end of 2018. Upon assuming the role of President and CEO on ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... , Oct. 5, 2017  In response ... of Oral and Maxillofacial Surgeons (AAOMS) released prescribing ... – to be used as a first-line therapy ... Recognizing the ... AAOMS White Paper "Opioid Prescribing: Acute and Postoperative ...
Breaking Medicine Technology: