Navigation Links
Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer

Switching off a mammalian protein called Rad9 could hold the key to killing cancer cells easily with ionizing radiation, according to new research at Washington University School of Medicine in St. Louis. Rad9 was previously thought // to be a "watchman" for DNA, but it is now fund to be a "repairman" for DNA that fixes any breaks in the master molecule.

That is why reserachers are now looking at Rad9 with renewed interest. Turning off the protein could make the radiation treatments more effective, the reserachers say in the study, which appears online in the journal Molecular and Cellular Biology. "Our study suggests that if we could inactivate Rad9 in tumor cells, we would be able to kill them with a very low dose of radiation and gain a therapeutic advantage," observed lead author Tej K. Pandita, Ph.D., associate professor of radiation oncology and on the faculty of the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. The study found that Rad9 proteins interact with telomeres in the chromosomes. These telomeres are special structures located at the ends of chromosomes and protect them from fusion or degradation. "We saw that Rad9 stabilizes telomeres, and because we aren't yet sure how it does it, we will continue to study how Rad9 influences the telomere structure," Pandita said. "We speculate that without Rad9, some of the other proteins associated with the telomeric structure become delocalized, exposing the DNA at the ends of chromosomes." The reserachers are also looking at ways to identify people with mutations in Rad9, since they definitely expose people to the risk of developing cancer, "If Rad9 isn't functioning properly in cells, it can lead to genomic instability and result in the malignant transformation of cells," Pandita commented. "In fact, fusions at the telomeric ends of chromosomes like those seen in the absence of Rad9 appear frequently in tumor tissues." Main Article: Pandita RK, Sha rma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase specific cell survival and homologous recombinational repair. Molecular and Cellular Biology March 2006;26(5):1850-1864.
'"/>




Related medicine news :

1. Switching drugs regularly improves HIV treatment
2. Switching Genes to Overdrive Improves Muscular Dystrophy Symptoms in Mice
3. Lean Protein Could Be Key to Obesity Drugs
4. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
6. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
7. Protein in urine foresees heart disease
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Protein signals need for heart surgery
10. Protein and fat improve memory
11. Clotting Protein plays a role in nerve repair
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Columbus OH. Dr. Justin Harper, Founder ... few medical professionals in the country to sit on the 2017 National Advisory Board ... just 2 years Dr. Harper helped propel the clinic from a small start-up to ...
(Date:3/28/2017)... ... March 28, 2017 , ... Prominant bariatric ... Inc. is thrilled to offer the recently FDA-approved Obalon Balloon System to his ... to SkyLex Advanced Surgical’s already comprehensive list of weight-loss services. Dr. Liu ...
(Date:3/28/2017)... ... , ... With expansion and efficiency in mind, Patten Seed Company completed relocation ... plant opened in Marshallville in 2006, and a bagging and shipping facility has been ... of Patten Seed operations to the Middle Georgia location from their previous home in ...
(Date:3/28/2017)... ... ... you to all who attended Capio Partners Winter 2017 Healthcare Leadership Symposium in beautiful ... offered an opportunity to collaborate and network with healthcare colleagues across the United States. ... for a lively discussion on trends and issues that healthcare leaders will face in ...
(Date:3/28/2017)... California (PRWEB) , ... March 28, 2017 , ... Bacteria and fungi are probably not ... microorganisms are bad. In fact, including the right microorganisms in your diet can actually improve ... favorite foods. , This is the topic of a new peer-reviewed paper ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TEL AVIV, Israel , March 28, 2017 ... . This new business entity, Emosis Ltd, headquartered in ... and development of novel assays complementing the mother company existing technology ... support commercialization and sales development of Emosis kits. ... This strategic move starts building Emosis ...
(Date:3/28/2017)... , March 28, 2017  AcelRx Pharmaceuticals, ... on the development and commercialization of innovative therapies ... that the European Medicines Agency (EMA) has notified ... 30 mcg) Marketing Authorisation Application (MAA) has passed ... MAA is underway. The MAA for ARX-04 (known ...
(Date:3/28/2017)... RXi Pharmaceuticals Corporation (NASDAQ: RXII), a ... significant unmet medical needs, today announced that it ... Office (JPO) for the composition of matter of ... the treatment or prevention of fibrotic disorders, including ... retinopathy (Japanese Patent #: 6060071).  This patent includes ...
Breaking Medicine Technology: