Navigation Links
Switching Genes to Overdrive Improves Muscular Dystrophy Symptoms in Mice

y of genes under its control. Exercising a muscle raises PGC-1alpha levels, causing the formation of more mitochondria, the chemical power plants that create energy in cells.

PGC-1alpha is also required for the normal operation of genes that control the development of neuromuscular junctions (NMJ) – sites on muscle fibers where nerves attach and signal the fibers to contract. Part of the reason that exercise builds stronger muscles is that it increases PGC-1alpha activity. Conversely, disease or lack of exercise reduces PGC-1alpha activity, causing a loss of NMJ function and weakening, or atrophying, of muscles.

Spiegelman’s team had previously bred a strain of mice with higher-than-normal levels of PGC-1alpha in their muscles. Also available for the research was a mouse model of Duchenne muscular dystrophy, the MDX mouse. In the new experiment, the scientists bred male high-PGC-1alpha mice with female MDX mice (the muscular dystrophy gene is carried by females in mouse and in humans.) As a result, the offspring of these matings had muscular dystrophy but also had elevated PGC-1alpha. Using exercise and chemical tests, the researchers compared muscle function in the offspring with MDX mice having no additional PGC-1alpha.

Both sets of rodents were run on a treadmill for one hour, then again 24 hours later. Normal mice completed the runs easily on both days, while untreated MDX rodents were exhausted halfway through each run. The MDX mice with increased PGC-1alpha activity performed almost as well as normal mice on the first day; their performances decreased on the second day, but they still did better than the untreated MDX mice on both runs.

The exercise tests and microscopic and chemical examinations of the muscles showed that boosting PGC-1alpha caused “a clear and substantial improvement in the structure and function of skeletal muscle in this disease model,” the scientists wrote.

Source-Eurekaler
SR
'"/>




Page: 1 2 3

Related medicine news :

1. Switching drugs regularly improves HIV treatment
2. Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer
3. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
4. Genes for lung disease
5. Genesis of SUPAC
6. Genes for Vision discovered
7. Genes Found To Help Leukemia Treatment
8. Cardiac Valve Disease Linked To Genes
9. Genes Linked To Cigarette Addiction
10. Genes from saliva may predict oral and breast cancer
11. Genes More Important Than Exercise for Bad Cholesterol
Post Your Comments:
(Date:10/22/2014)... (PRWEB) October 22, 2014 Shriners Hospitals ... that will change the current location of Shriners Hospitals ... South Limestone across from the University of Kentucky Albert ... state-of-the-art ambulatory care center, owned and operated by Shriners ... orthopaedic needs of children and their families well into ...
(Date:10/22/2014)... Angeles, California (PRWEB) October 22, 2014 Hay ... 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; $10.82) ... field of Yoga & Recovery. This book is meant ... thrive in a life of recovery. , Recovery 2.0 ... the 12 Steps; Recovery 2.0 is a guide for what ...
(Date:10/22/2014)... Pass, OR (PRWEB) October 22, 2014 ... Southern California’s fresh water supply runs dangerously low, Southern ... change. Southern Oregon’s rivers, despite the lowest mountain snow ... even in late summer and early autumn.* That was ... authors of the new book “Hiking Southern Oregon,” during ...
(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
(Date:10/22/2014)... Although there are only 24 hours in a day, ... have trouble finding time within their busy schedules for exercise and ... of time to get in shape. Here are five ways you ... , Change Up Your Commute , Consider riding a bike ... exercise into your daily routine. If you must use your car ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2
... study on sleep patterns in American women found that most of ... and physical health// , personal lives, professional work and driving safety. ... Foundation, studied about 1,003 adult women in ages 18 t0 65 ... get less than one or two nights of good sleep each ...
... Smailholm and the border areas has raised the concern ... village hall where drumming classes were being conducted. ... Sabre, to look into this matter. The finding revealed ... areas in Northumberland and the Borders, including Smailholm Village ...
... consulate in Hyderabad will start operations in a makeshift location ... permanent// facility in five years time. ,The US ... April so that work could begin to set up the ... by Henrietta H. Fore, under secretary of state for management, ...
... says a study that adds to a weight of evidence ... the peppers their zing. ,According to the latest ... National Chung Hsing University in Taiwan, capsaicin makes fat cells ... ,The result of the study is reported in the Journal ...
... from the renowned Salk Institute for Biological Studies, have discovered ... secretion will not only reduce insulin resistance, in animal models, ... high calorie diet. , The peptide in question ... are peptides produced in the insulin secreting cells ...
... 2007 -- A team of UCSB researchers, in collaboration ... of Los Gatos, California, has designed a novel ... the skin without the pain or bruising that deeper ... today in the Proceedings of the National Academy of ...
Cached Medicine News:Health News:Sleep Problems of Women 2Health News:US Consulate to Start Hyderabad Operations Next Year 2Health News:Scientists Explore Ways to Reduce Insulin Resistance by ‘handcuffing’ Gen 2Health News:Researchers Design Pulsed Mircrojet System to Deliver Protein Drugs Without Pain or Bruising 2
(Date:10/20/2014)... Calif. , Oct. 20, 2014  PneumRx, Inc. ... interventional pulmonology, today announced completion of enrollment in their ... RENEW Clinical Study is the FDA-approved IDE pivotal trial ... severe emphysema. It was anticipated that the ... February 2013, would take until the end of 2014 ...
(Date:10/20/2014)... BOSTON , Oct. 20, 2014  Indianapolis ... and Toronto -based 3D visualization ... the Congress of Neurological Surgeons Annual Meeting that ... technologies for brain surgery. The collaboration is the ... powerful combination to improve patient outcomes. NICO,s BrainPath® ...
(Date:10/20/2014)... 2014  ResMed (NYSE: RMD ) ... Exchange program, a comprehensive suite of software and ... other health care providers. ResMed ... patient information. It integrates valuable sleep and respiratory ... management platforms with customers, in-house or third-party electronic ...
Breaking Medicine Technology:PneumRx Completes RENEW Pivotal Trial Enrollment 2PneumRx Completes RENEW Pivotal Trial Enrollment 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 2Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 3Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 4Indianapolis' NICO Corporation and Toronto's Synaptive Medical, Inc. Announce First-Ever Intervention-Visualization Partnership with Goal to Improve Standard of Care in Neurosurgery 5ResMed Launches ResMed Data Exchange 2
... ST. PAUL, Minn., Oct. 28 M.B.A. students ... and CEO Eric Elliott speak about the history ... Therapeutics is a pharmacy benefit management company dedicated ... clients and members. In a speech ...
... 28, 2010 The enVision e ICU® Center ... Virginia Hospital Alliance (NVHA) Regional Hospital Coordinating Center to ... surge capabilities in the region.  Inova,s enVision e ... using eICU Program technology from Philips VISICU. ...
Cached Medicine Technology:Columbia University Students Learn About Pharmacy Benefit Management From Prime Therapeutics President and CEO 2NVHA and Inova Health System Utilize Philips VISICU eICU® Program to Increase Surge Capacity During All-Hazards Event 2NVHA and Inova Health System Utilize Philips VISICU eICU® Program to Increase Surge Capacity During All-Hazards Event 3
Autolensmeter with black/white monitor and no internal printer....
FF 450plus IR Fundus camera with Visupac / System 451. High-end system for visualizing even the finest detail and reliable diagnosis....
... CL-100 measures all types ... with improved precision. The ... senses multi-focal lenses with ... makes operation easier while ...
... is designed for fast and easy operation ... mode, the readings are automatically held when ... are automatically detected. The sophisticated alignment system ... The TL-2000A has been designed with a ...
Medicine Products: