Navigation Links
Switching Genes to Overdrive Improves Muscular Dystrophy Symptoms in Mice

y of genes under its control. Exercising a muscle raises PGC-1alpha levels, causing the formation of more mitochondria, the chemical power plants that create energy in cells.

PGC-1alpha is also required for the normal operation of genes that control the development of neuromuscular junctions (NMJ) – sites on muscle fibers where nerves attach and signal the fibers to contract. Part of the reason that exercise builds stronger muscles is that it increases PGC-1alpha activity. Conversely, disease or lack of exercise reduces PGC-1alpha activity, causing a loss of NMJ function and weakening, or atrophying, of muscles.

Spiegelman’s team had previously bred a strain of mice with higher-than-normal levels of PGC-1alpha in their muscles. Also available for the research was a mouse model of Duchenne muscular dystrophy, the MDX mouse. In the new experiment, the scientists bred male high-PGC-1alpha mice with female MDX mice (the muscular dystrophy gene is carried by females in mouse and in humans.) As a result, the offspring of these matings had muscular dystrophy but also had elevated PGC-1alpha. Using exercise and chemical tests, the researchers compared muscle function in the offspring with MDX mice having no additional PGC-1alpha.

Both sets of rodents were run on a treadmill for one hour, then again 24 hours later. Normal mice completed the runs easily on both days, while untreated MDX rodents were exhausted halfway through each run. The MDX mice with increased PGC-1alpha activity performed almost as well as normal mice on the first day; their performances decreased on the second day, but they still did better than the untreated MDX mice on both runs.

The exercise tests and microscopic and chemical examinations of the muscles showed that boosting PGC-1alpha caused “a clear and substantial improvement in the structure and function of skeletal muscle in this disease model,” the scientists wrote.

Source-Eurekaler
SR
'"/>




Page: 1 2 3

Related medicine news :

1. Switching drugs regularly improves HIV treatment
2. Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer
3. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
4. Genes for lung disease
5. Genesis of SUPAC
6. Genes for Vision discovered
7. Genes Found To Help Leukemia Treatment
8. Cardiac Valve Disease Linked To Genes
9. Genes Linked To Cigarette Addiction
10. Genes from saliva may predict oral and breast cancer
11. Genes More Important Than Exercise for Bad Cholesterol
Post Your Comments:
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... MarketsandMarkets recently conducted a study on the ... rendering; Layout and Animation; Image Reconstruction]: Global Advancements, ... analyzes and studies the major market drivers, restraints, ... Europe, Middle East and Africa, Asia-Pacific and Latin ... of the 3D imaging market, providing an in-depth ...
(Date:7/13/2014)... Gordon HealthDay Reporter FRIDAY, ... of sensor for people with diabetes is being developed to ... blood, researchers report. Scientists at Brown University in Providence, ... saliva. It uses light, metal and a special enzyme that ... that diabetics have to prick their fingers to draw blood ...
(Date:7/13/2014)... July 13, 2014 Athletes with a ... period from concussions, according to research presented today at ... ) Annual Meeting. The research marks the first of ... on the known physical events that occur after a ... a long allele in the (GT)n genotype were four ...
(Date:7/13/2014)... Recently, 2014QuinceaneraDresses.com, the distinguished special ... new range of gorgeous Quinceanera dresses . ... for elegant Quinceanera outfits is huge. Therefore, 2014QuinceaneraDresses.com ... the company’s newly released dresses are made according ... elegant and vivid. , It is worthy ...
Breaking Medicine News(10 mins):Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2
... bridge diabetes and obesity research and treatment , ... and Burnham Institute for Medical Research at Lake Nona have ... for medical research. Today, officials from Florida Hospital and Burnham ... R. Smith, an internationally-renowned diabetes and obesity researcher, as the ...
... , MILWAUKEE, Aug. 17 ... the top performing health system in the country in a national ... initiative. This is the second consecutive year that Aurora has ... Demonstration project that involves 250 hospitals from across the country. , ...
... a problem , , MONDAY, Aug. 17 (HealthDay News) -- ... psychologically damaged from merciless teasing, a new study provides reassurance ... exposure to short jokes. , The study, which appears in ... children reported being teased only slightly more than their peers, ...
... , CHICAGO, Aug. 17 Fueled by ... time when melanoma rates are on the upsurge in younger females, ... will offer free skin cancer screenings and sun safety education to ... and the PING Junior Solheim Cup. , , ...
... ... designed to give prospective patients an idea of what the future can hold. Dr. Jack ... surgery in Dallas a view of what they think would look best for that ... , ...
... ... ... largest providers of specialty products and services for the workers, compensation market, today announced that Lori ... excited to have Lori join PMSI in this critical role. She is a natural fit based ...
Cached Medicine News:Health News:Florida Hospital and Burnham Institute Announce New Executive Director and Facility for Clinical Research Institute 2Health News:Florida Hospital and Burnham Institute Announce New Executive Director and Facility for Clinical Research Institute 3Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 2Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 3Health News:Aurora Health Care Top Performing Health System in National Quality Initiative 4Health News:For Short Kids, No Lack of Self-Esteem 2Health News:For Short Kids, No Lack of Self-Esteem 3Health News:Illinois Dermatologists Tee Up for Sun Safety at Two World-Class Golf Championships 2Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 2Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 3Health News:Dr. Jack P. Gunter Offers 3D Imaging for Dallas, Texas Plastic Surgery Patients 4Health News:PMSI Appoints Lori Daugherty as President of Pharmacy Division 2
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., a ... has launched the FreeRunner™ knee brace with new ... from patella mal-tracking return to active lifestyles.  FreeRunner,s ... other braces, providing support when patients need it ... they don,t. Patellofemoral issues are the ...
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
(Date:7/10/2014)... TUCSON, Ariz. , July 10, 2014   ... Roche  Group, today announced it has entered into an ... , which operates as EMD Serono in ... , to collaborate with Merck KGaA,s biopharmaceutical division ... (CDx) for an undisclosed target using Ventana,s proprietary diagnostic ...
Breaking Medicine Technology:Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3
... Wis., Sept. 16 Top researchers at the Gastrointestinal ... Dallas are exploring the clinical applications of BCM-95®, a ... bioavailability. Previous studies have shown that ... forms of curcumin, and had a retention time in ...
... Mich., Sept. 16 Metabolic Solutions Development Company (MSDC), ... Association for the Study of Diabetes (EASD) annual conference ... indicates that the company,s clinical candidate, MSDC-0160, promotes the ... to the creation of more brown fat.  The research ...
Cached Medicine Technology:BCM-95 Demonstrates Superior Anti-Inflammatory Effects 2Metabolic Solutions Development Company to Present Research Findings to European Association for the Study of Diabetes 2
... Digital offers improved ergonomics for today's ... modified grippy finger rest and the ... and efficiency. Finnpipette Digitals also feature ... mechanism (pat. pend.) and super blow-out ...
... The AlphaPette Pipettor is the #1 ... Offers accuracy, comfort, and reliability. Continuously ... volume readout sub-micrometer. Easy interchangeable ejector ... tiny hands. Adjustable rapid pipet tip ...
... moderate viscosity and density. Proven ergonomic design reduces hand fatigue, prevents injury. ... 1000-5000 ... 0.8~1.5 Imprecision(%) ... 10 Dimensions: ...
Pipetman P is a fully adjustable, air-displacement pipette with the selected volume shown on a digital indicator (volumeter). Eight models cover the full range of volumes from 0.2 L to 10 mL....
Medicine Products: