Navigation Links
Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants

A new study has reported that there appears to be three variations of a human gene that seem to cause an impact on humans upon their susceptibility towards tuberculosis// . Researchers hope that these findings would provide sufficient knowledge as to why some patients infected with the Mycobacterium tuberculosis pathogen develop the full-blown disease while others are seemingly not affected. The findings was published in the online edition of the Proceedings of the National Academy of Sciences (PNAS) (http://www.pnas.org/) for the week of June 19-23,

The paper additionally describes how the association of two of the gene variants with the disease has been replicated.

Approximately one-third of the world's population is thought to be infected with the M. tuberculosis pathogen, yet only about 10 percent becomes ill with the active disease. Researchers suspect that a variety of factors interplay to determine who develops the full-blown disease. For example, in February 2006 Harvard School of Public Health (HSPH) researchers were part of a team that identified a mechanism that explains why people of African descent may be more vulnerable to the disease.
(http://www.hsph.harvard.edu/press/
releases/press02232006B.html)

Now HSPH Associate Professor Igor Kramnik is part of a team led by Professor Adrian V.S. Hill of Oxford University that has identified three variations of a human gene associated with tuberculosis susceptibility. The lead author on the paper is Kerrie Tosh of the Welcome Trust Centre for Human Genetics in the U.K.

Kramnik and his colleagues had previously identified a gene in mice called Ipr1 (intracellular pathogen resistance 1) that plays a significant role in limiting the multiplication of intracellular pathogens M. tuberculosis and Listeria monocytogenes inside host cells.
(http://www.hsph.harvard.edu/press/
releases/press04062005.html)

The Hill team then examined the closest ho molog of the mouse gene Ipr1 that can be found in humans--a gene called SP110. Three variations of the SP110 gene were found to be associated with tuberculosis in humans.

The variations of SP110 emerged from an analysis of 20 pieces of genetic material called SNPs that were culled from an original set of 27 SNPs taken from samples provided by 219 families in The Gambia. Two of the variations and their association with tuberculosis were further replicated in samples from 99 families in the Republic of Guinea and 102 families in Guinea-Bissau.
'"/>




Related medicine news :

1. Popularity Among Peers Increases Susceptibility To Smoking Habit Among School Children
2. Smoking Related Scenes in Movies Increase Teenage Susceptibility To Smoke
3. A Sneak Preview of Human’s Susceptibility to Auto Immune Disease, Allergy, Asthm
4. Gene Defects Determine Susceptibility to Cancer and Bone Marrow Failure
5. Gluten Intolerance Quadruples Susceptibility to Tuberculosis
6. Web-Based Genomics Tool Designed to Help Predict Disease Susceptibility
7. Susceptibility to TB is High Among the Smokers
8. First Vaccine Designed for Africa Cleared for Testing in Humans
9. Humans Found To Have The Ability To Block Unwanted Memories
10. US Senate Votes against Testing of Pesticide on Humans
11. Limb Regeneration In Humans: A Future Possibility
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2017)... ... May 27, 2017 , ... From May 21-23, hearing healthcare professionals ... event was held at the Marriott Syracuse Downtown Hotel in Syracuse, New York. ... network of independent hearing healthcare providers to help them stay ahead in the industry. ...
(Date:5/26/2017)... Boston, Massachsetts (PRWEB) , ... May 26, 2017 ... ... communities will gather at Boston CEO 2017 on May 30th and 31st at ... off-the-record networking forum for leading executives in the life sciences, offering exclusive access ...
(Date:5/26/2017)... ... May 26, 2017 , ... A new analysis of community ... healthiest seniors are located in the Midwest. With the average cost of healthcare rising ... are concerned with both the quality and affordability of where they live. An annual ...
(Date:5/26/2017)... MD (PRWEB) , ... May 26, 2017 , ... After ... anti-stress Antzy Top gadget will continue to be available at a discounted crowdfunding price ... deal with stress wherever they are, I also wanted to bring a fidget toy ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Dr. Alex ... proud to announce a new, informational blog post on insurance options. If a Bay ... insurance plans may help save time and money. Visiting an in-network provider for a ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017  Semler Scientific, Inc. ... technology solutions to improve the clinical effectiveness and ... for the first quarter ended March 31, 2017. ... enable our customers to identify when preventive care ... before events like heart attacks or strokes occur," ...
(Date:5/6/2017)... is Stroke Awareness Month and Omron Healthcare is reminding ... prevent a stroke: monitor and manage your blood pressure. ... undetected and uncontrolled hypertension is a leading risk factor ... personal heart health technology, recently evolved its mission to ... and is advancing a national public education effort to ...
(Date:5/4/2017)... , May 4, 2017 Clarius Mobile ... wireless, handheld ultrasound scanners this week at the ... Meeting (ACOG) in San Diego, CA ... "Clarius is the perfect tool for clinicians ... heart rate, and evaluate pregnancy-related complications like ectopic ...
Breaking Medicine Technology: