Navigation Links
Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"

A study conducted by the Cancer and Leukemia Group B (CALGB) and presented at the 25th Annual San Antonio Breast Cancer Symposium assessed the effectiveness of reducing the interval between successive doses of a commonly used chemotherapy regimen to improve survival rates in breast cancer// women. This study was conducted as follow-up of a mathematical model which was developed in the 1980s that suggested the value of increased dose density.

Researchers tested both dose dense and conventional chemotherapy regimens in 1,973 women with node-positive primary breast cancer and no other metastases. Following surgical removal of their tumors, the women were assigned to one of four treatment regimens involving the standard chemotherapy drugs doxorubicin (A), paclitaxel (T), and cyclophosphamide (C):

Sequential administration (A followed by T, followed by C) in three-week intervals (conventional)

Sequential administration in two-week intervals, with filgrastim (dose dense)

Concurrent administration (A and C together, followed by T) in three-week intervals

Concurrent administration in two-week intervals, with filgrastim (dose dense)

The dose dense regimen was made tolerable to patients with the drug filgrastim, which helps prevent neutropenia, a serious complication of chemotherapy. In neutropenia there is a decline in the number of a certain type of white blood cells which hampers the immune system of the body. Filgrastim, also known as the granulocyte-colony stimulating factor (G-CSF), helps prevent neutropenia by stimulating the formation of white blood cells called neutrophils. Without it, chemotherapy dosing frequency is limited to longer intervals.

The researchers found that the disease-free survival was 82 per cent after four years compared to 75 percent for those who received conventional therapy. This difference corresponded to a 26 percent overall reduction in the risk of cancer recurre nce. They also found that the efficacy did not differ between the two dose regimens.

The study also indicated that dose dense chemotherapy could lead to higher overall survival rates. After three years, 92 percent of patients on the dose dense therapy were alive, compared to 90 percent of those on the conventionally administered regimens. This difference corresponded to a 31 percent overall reduction in the risk of death. However, the study authors cautioned that additional follow-up is necessary to confirm this overall survival benefit.

The study also found that patients on dose dense chemotherapy did not have increased side effects than those on the conventional treatments. It was also found that sequential administration produced slightly fewer side effects than the concurrent regimens, with equal efficacy.

Larry Norton, M.D., of Memorial Sloan-Kettering Cancer Center, Senior investigator of the study believed that this study which showed an improvement due to dose dense chemotherapy could advance knowledge of the biology of breast cancer and how best to treat it. He also added that further confirmed studies would affect the care of thousands of patients throughout the world with breast cancer and perhaps, eventually, other diseases.

Researchers also hypothesize that future clinical trials could examine the benefits of dose dense chemotherapy using other drugs and in other types of cancer as the mathematical model on which the study was based applied to most cancer types and many anti-cancer drugs.


Related medicine news :

1. Long-Term Survival can be Predicted by a Simple Lung Test
2. Hepatitis G May Boost HIV Survival
3. Longer Lung Cancer Survival
4. ICU Survival can be improved by Antibiotic use
5. Vasopressin Found To Boost Survival In Sudden Cardiac arrest
6. Improving Survival Rate Of Lung Cancer Patients
7. Combination Therapy Effective In Improving Lung Cancer Survival
8. Symptoms Found To Be A Good Predictor Of Cancer Survival
9. Survival Of Colon Cancer Patients
10. Public Defibrillators Found To Improve Survival Rate
11. Body Weight Found To Affect Breast Cancer Survival
Post Your Comments:

(Date:11/30/2015)... , ... November 30, 2015 , ... The world of ... harvesting and follicular unit extraction. These techniques and procedures have been in use for ... from hair loss. While Dr. Parsa Mohebi, M.D. has utilized many of these methods ...
(Date:11/30/2015)... Battle Creek, Michigan (PRWEB) , ... November 30, 2015 , ... ... Creek, MI, the American Cancer Society held an annual fundraising event, a 5K walk ... Recovery, a holistic treatment center for substance abuse which is also located in Battle ...
(Date:11/30/2015)... ... November 30, 2015 , ... The presidential race normally deals with political issues ... it a national news story when Donald Trump makes disparaging remarks about Hillary Clinton’s ... more than anyone wants to admit when it comes to how people are viewed ...
(Date:11/30/2015)... Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... star Jessie James Decker made a brave but slightly unusual choice to show her ... returning to her pre-pregnancy form may have been pre-mature. Saying that she didn’t “want ...
(Date:11/30/2015)... ... ... According to Los Angeles bariatric surgeon Michael Feiz, M.D., F.A.C.S., many of ... hunger, but instead by a hormone called ghrelin which (often prematurely) signals to ... aware that weight loss surgery can help patients lose weight by restricting the capacity ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... --  Royal Philips  (NYSE: PHG ; AEX: ... a fully integrated, consultative approach to enhance radiology ... management approaches that combine imaging systems, services, informatics ... delivery and reduce costs. Making its debut at ... Annual Meeting (RSNA) in Chicago ...
(Date:11/30/2015)... CHICAGO , Nov. 30, 2015 Nautilus ... next-generation Radiology Image Management platform ( ). The ... was announced from RSNA 2015 (Radiology Society North America) ... Radiology conference in the U.S. --> ... radiology platform that enables access to radiology studies worldwide ...
(Date:11/30/2015)... (HK$,000)For the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 , 518,852 ... , 384,242 , 9.8 Hospital ... , (18.3) Medical Insurance Administration Service Income , ... Medical Devices and Accessories Sales , 89,645 , ... , 2,822 , 2,917 , ...
Breaking Medicine Technology: