Navigation Links
Survival rates improve with better treatment options for medulloblastoma

Study led by St. Jude finds that by tailoring the intensity of radiation to individual patients and cutting short the length of intensive chemotherapy improves outcome for those// suffering medulloblastoma.

A team of investigators led by St. Jude Children’s Research Hospital has announced that improved treatment measures for childhood brain cancer medulloblastoma have markedly enhanced the rate of survival of children with this disease.

The treatment increased the overall five-year survival for 86 children with average-risk medulloblastoma from the current rate of 70 percent to 85 percent; and raised the rate of survival among the 48 high-risk patients from 55 percent to 70 percent. Patients are considered to be at average risk of treatment failure if their cancer has not spread following initial surgery to remove the tumor, or if the remaining tumor is very small. Patients are considered at high risk of failure if their tumor has spread following surgery or if the remaining tumors are larger than those of low-risk patients.

A report on these results appears in the September 7 issue of Lancet Oncology.The investigators were able to achieve the improved survival rates while reducing the amount of radiation and length of chemotherapy following surgery in average-risk patients from levels used in standard treatments, according to Amar Gajjar, M.D., co-chair of the St. Jude Department of Oncology and director of its Neuro-Oncology Division. The chemotherapy for average-risk patients was completed in 16 weeks, versus the standard treatment, which lasts 48 weeks. The new treatment not only reduced radiation to the brain and spinal cord, but also reduced the level of two chemotherapy drugs by 75 percent and 50 percent, respectively. This reduction in radiation and chemotherapy holds promise for lessening the long-term, troublesome side effects on intellectual development of young patients treated for this cancer, Gajjar said. In add ition to improving overall five-year survival of average-risk patients to 85 percent, this group had an 83 percent rate of event-free survival and a rate of five-year, event-free survival of 70 percent for high-risk patients. Event-free survival means that a child did not have medical complications or relapse that required further treatment.

Moreover, the improved treatment achieved a survival rate of 66 percent as compared to 30-40 percent among children whose cancer had spread.

The results of the current clinical trial, SJMB96, are especially significant because they represent a dramatic change from the 45 percent survival rate achieved two decades ago using just surgery and irradiation, according to Gajjar. The subsequent addition of chemotherapy before or after radiotherapy improved that survival rate to 65 percent for children aged 3 years or older who had medulloblastoma.

"We attribute our very promising results to the early use of high-dose radiotherapy after surgery--rather than waiting until after chemotherapy--in combination with short-term, intense chemotherapy," Gajjar said. "Shorter-term, intense chemotherapy is an especially important component of treatment that contributes to the improved survival of high-risk patients."

The researchers also showed that genetic differences exist in medulloblastoma tissues among children. These differences could be used to differentiate between children whose tumors are very aggressive and require novel experimental treatment and those children whose tumors are less aggressive and who could benefit from further reduction in treatment.

"These additional studies suggest that we can further reduce the long-term effects of treatment among some children by further reducing the treatment intensity," Gajjar said. The researchers previously reported that medulloblastoma consists of several distinct subgroups of this cancer that can be identified according to specific genetic abnormalities.

Source-Eurekalert
'"/>




Related medicine news :

1. Long-Term Survival can be Predicted by a Simple Lung Test
2. Hepatitis G May Boost HIV Survival
3. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
4. Longer Lung Cancer Survival
5. ICU Survival can be improved by Antibiotic use
6. Vasopressin Found To Boost Survival In Sudden Cardiac arrest
7. Improving Survival Rate Of Lung Cancer Patients
8. Combination Therapy Effective In Improving Lung Cancer Survival
9. Symptoms Found To Be A Good Predictor Of Cancer Survival
10. Survival Of Colon Cancer Patients
11. Public Defibrillators Found To Improve Survival Rate
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is ... Top Doctor for 2017. Each year, research and information firm, Castle Connolly, releases their ... title in 2015, this marks the 3rd time that Dr. Canales has ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... grant from the American Heart Association (AHA) to launch a Rheumatic Heart Disease ... the prevention and diagnosis of rheumatic heart disease (RHD) in high-risk, financially disadvantaged ...
(Date:6/22/2017)... ... June 22, 2017 , ... Vighter, a premier ... received certification for ANSI/ASIS PSC.1-2012. The company’s work in countries throughout Southwest Asia, ... of law has been degraded. The PSC.1 standard was created to protect fundamental ...
(Date:6/20/2017)... Tennessee (PRWEB) , ... June 20, 2017 , ... ... care services, announced today that Claritas Capital, a Nashville-based private equity firm, has ... accelerate our expansion plans for some time, and Claritas Capital offers the smart ...
(Date:6/20/2017)... ... 2017 , ... After months of negotiations, FaceCradle USA is proud to announce the debut of ... , “Introducing our product on QVC is something we all worked hard to achieve for ... more than 90 million homes in the United States,” said FaceCradle USA President Dylan Doherty. ...
Breaking Medicine News(10 mins):
(Date:6/10/2017)... BESSEMER, Ala. , June 9, 2017  Shane K. Burchfield, ... Member recognized for excellence as a Podiatrist in Alabama ... of Podiatry at Family First Foot Care. He brings over 20 ... sports medicine, pain management and healthcare, to his role. ... Family First Foot Care, PC is pleased to welcome ...
(Date:6/8/2017)... , June 8, 2017  StatLab ... leading developer and manufacturer of diagnostic supplies ... today that Cressey & Company LP ("Cressey ... has completed a growth-focused investment in the ... majority ownership position from selling shareholder, Prairie ...
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
Breaking Medicine Technology: