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Surprising Interaction Between Genes, Gender, and Hypertension

as differently associated with blood pressure measurements in men versus women. Of 48 SNPs, two influenced blood pressure only in men, while two other SNPs contributed only in women. All four SNPs demonstrated significant gender-by-gene interaction effects on blood pressure. Two other SNPs also showed significant gene-by-gender interactions, but their effects were not significant in either men or women alone. Furthermore, the scientists documented several examples where particular gene variations were observed to show directionally opposite effects on blood pressure in men and women.

The researchers conclude that “the results suggest that development of genotype-based diagnostic and therapeutic indices for hypertension must take gender into account to provide an accurate assessment of the role of genes in the origin, treatment and consequences of this complex trait.”

“Further studies may help scientists understand what genetic variables can predict the likelihood of a patient suffering from hypertension,” said O’Connor. br>
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