Navigation Links
Surface Logix Commences Phase 2a Clinical Trial of SLx-2101 in Raynaud's Disease

BOSTON, -- Surface Logix Inc. today announced the initiation of a Phase 2a clinical trial for SLx-2101 in patients with secondary Raynaud's disease. SLx-2101 is a novel , long-acting PDE-5 inhibitor being developed for the management of diseases associated with vascular dysfunction such as Raynaud's, a vasospastic disorder of small blood vessels leading to a marked reduction of blood flow to areas such as the fingers and toes. Often triggered by exposure to cold, Raynaud's is associated with painful blue or white digits, and in severe cases, may lead to the development of digital ulcers.

"PDE-5 inhibition holds promise in several cardiovascular indications, though many disorders such as Raynaud's are currently not addressed by marketed PDE-5 inhibitors," commented Paul Sweetnam, Ph.D., Chief Scientific Officer of Surface Logix. "We used our novel chemistry platform to design SLx-2101 to have a profile that would deliver fast onset and long duration of therapeutic effects in difficult-to-treat conditions such as Raynaud's, potentially enabling quicker, longer-lasting relief to patients."

"The initiation of this trial is part of Surface Logix's multiple indication development plan for SLx-2101. We believe that it has applicability in cardiovascular indications beyond erectile dysfunction and are therefore pursuing its advancement in specialized indications, such as Raynaud's, as well as in larger cardiovascular markets," said Jim Mahoney, President and Chief Executive Officer of Surface Logix.

The Phase 2a trial is a single European center, randomized, double-blind, placebo-controlled, crossover pilot study that will enroll 20 patients with secondary Raynaud's disease. The trial is designed to examine the safety, tolerability and pharmacodynamic profile of repeat oral doses of SLx-2101 once daily for up to 14 days. The primary objective of this trial is to investigate the severity of secondary Raynaud's disease-related attacks during the dosing period. Secondary objectives include evaluating the frequency and total daily duration of disease-related attacks during the dosing period, the safety and tolerability of SLx-2101, and the effect of the drug on capillary blood flow velocity and vasospastic symptoms.

Surface Logix also initiated a Phase 2a clinical trial to test the safety, tolerability and pharmacodynamics of orally administered SLx-2101 in patients with hypertension in June 2007. Interim data from a Phase 2a study of SLx-2101 in erectile function confirmed its activity 48 hours after a single dose of 10mg, making it the first PDE-5 inhibitor to confirm such prolonged duration of activity using an objective measure.

Phase 1 studies of SLx-2101 in healthy male volunteers demonstrated its favorable safety, tolerability, pharmacokinetics and pharmacodynamic activity. Additionally, in preclinical animal models, the candidate was highly potent and selective, induced rapid cellular and tissue response and provided an extended duration of action.


'"/>




Related medicine news :

1. Lunar Forces Affect The Surface Of The Earth
2. Controversy Over The Fee Structure In Private Medical Colleges Surfaces Yet Again
3. Meningitis C Surfaces in Toronto:Public Alerted
4. New Study Links Western Wildfires to Atlantic Ocean Surface Temperatures
5. Copper Alloys Surfaces Touted As Pathogen Killers
6. Flesh-eating Bugs Surface in Singapore
7. InfoLogix, Inc. the Leading Healthcare Technology Company SaysHealthcare Informatics
8. Pfizer Commences Its Advertising for Celebrex with All the Warnings
9. Natco Pharma Commences Production At Dehradun Unit
10. Chinas First Gay Health Clinic Commences Operations
11. Mental Health - NHS Trust Commences Specialist Transition Service
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... ... May 02, 2016 , ... It has just been announced ... speaker for five events throughout the month of May. , Uldrich is the author ... news outlets. He also frequently appears on the Science Channel’s FutureScape and Discovery Channel’s ...
(Date:5/2/2016)... ... May 02, 2016 , ... ProElectric Cartoon is a package of 30 hand-drawn ... from a variety of electric styles including zap, sizzles, and more. Easily alter the ... blur, three dimensional rotation, and much more. ProElectric Cartoon’s simplistic style makes it the ...
(Date:5/2/2016)... ... May 02, 2016 , ... As directed by its board ... (HAP) issues its full support to allow certified nurse practitioners (CNP) to practice to ... have worked under such supervision for three years and 3,600 hours. , In addition, ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... traditions of innovation by partnering with college students at University of Colorado in ... CU-Boulder senior level advertising campaigns class in the School of Journalism, who selected ...
(Date:5/2/2016)... ... ... Eating Recovery Center’s Insight Behavioral Health Center (ERC Insight) , a ... eating disorder program under a new name: Eating Recovery Center, Chicago (ERC Chicago). ERC ... , To celebrate, ERC Chicago will host a ribbon-cutting ceremony and open house on ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 Treato , the ... announced today that it has been named a Cool ... in Life Sciences, 2016, Stephen Davies , ... focuses on life-science- oriented analytics, algorithms and smart machine ... doctors, confirm medication ingestion, and analyze unstructured information.   ...
(Date:4/28/2016)... Dr. Vivek Ahuja , ... Ste phen Schmidt ... of cloud-based software solutions for life sciences, today announced key new ... wealth of insight to a growing business.  This will bolster the ... George Phillips joined ArisGlobal in the position of Vice President ...
(Date:4/28/2016)... N.J. , April 28, 2016   Acsis ... today announced that leading IT market research and advisory ... " in the IDC MarketScape: Worldwide Pharmaceutical Track and ... 2016).  The report provides an assessment of the capabilities ... track and trace software market. Logo - ...
Breaking Medicine Technology: