Navigation Links
Super Chow, Laced With Semi-Synthetic Vitamin E, Inhibited Spread of Cancer

A chemically altered form of vitamin E mixed into mouse chow dramatically reduced spread of aggressive mammary cancer in mice//, suggesting that the compound in pill form could be used to treat human metastatic cancer, according to a report in the October 1 issue of the journal Cancer Research.

The study, by investigators at the University of Arizona, is the first to show that the synthetic compound has potent anti-cancer properties when given in the simplest way possible - as a dietary supplement.

“We tried other ways of delivering different forms of the synthetic vitamin, such as by force feeding and injections, but found that one form, alpha-TEA, was more effective when incorporated into food, and that makes it much more clinically useful,” said the study’s lead investigator, Emmanuel T. Akporiaye, Ph.D., professor in the Department of Immunobiology at the University of Arizona.

Mice eating the super chow had a 4.8-fold reduction in the number of tumors that spread to the lungs, compared to control mice, Akporiaye said. An even greater effect was seen when the animals began eating alpha-TEA-laced food as a cancer preventive, he said.

“These preliminary studies are very promising, and it could be that combining this synthetic vitamin E derivative with other anti-cancer treatments may offer the potential of both treating and preventing human breast cancer,” Akporiaye said.

Although vitamin E (alpha tocopherol) is an anti-oxidant, it cannot destroy tumor cells by itself, he said. To improve the vitamin, derivatives have been created by swapping a hydroxyl chemical group with an acid. One is alpha-tocopheryl succinate (?-TOS), which used a succinic acid residue, and another is alpha-tocopheryloxyacetic acid (alpha-TEA), which used acetic acid.

Replacing the hydroxyl group in vitamin E helps force cancer cells to self destruct, Akporiaye said, because the compounds work to free up pro-apoptotic pro teins that are normally held in check within cells. “Cell survival is maintained when pro-apoptotic proteins are confined, and these synthetic forms of vitamin E release them, pushing the cell into committing suicide,” he said.

“Only a little part of vitamin E is changed in these synthetic derivatives, but they show amazing anticancer properties, and they selectively target tumor cells,” Akporiaye said.

To make the synthetic vitamins water soluble (not fat soluble like natural vitamin E), researchers have added sodium hydroxide. In this way, these vesiculated forms, called V?-TOS and Valpha-TEA, can be delivered clinically through injection or oral gavage (feeding through a tube), and experiments have shown they can treat melanoma, lung and breast cancer in rodent models.

In this study, the Arizona researchers evaluated the anti-tumor effect of V?-TOS and Valpha-TEA on mice with an aggressive form of mammary cancer that is similar to human breast cancer that readily metastasizes. They also looked at how well alpha-TEA would affect tumor growth if incorporated into the food (“chow”) that the mice ate.

They found that injecting V?-TOS or Valpha-TEA into the peritoneal cavity of the mice reduced the average volume of tumors by two fold, compared to control mice that did not receive the injections. Administering V?-TOS daily through a feeding tube had the same effect on tumor size, but V?-TOS was ineffective when delivered in this way, Akporiaye said. “We found that V?-TOS wasn’t stable, and returned to its natural vitamin E state,” he said.

To gauge the effectiveness of a dietary treatment, the researchers had special rat chow manufactured that incorporated a fairly large quantity of alpha-TEA into the food. They then tested the chow as a cancer preventive and as a cancer treatment.

For the prevention study, the mice ate alpha-TEA chow starting on the same day that they were injected with rodent ma mmary tumor cells known to spread quickly to the lungs and bones. The mice were allowed to eat as much food as they wanted, and at the end of 29 days, the average tumor volume was reduced by 6.7-fold, compared to control mice who had not been fed alpha-TEA.

In the therapy experiment, mice started eating alpha-TEA chow 11 days after tumors were implanted, and in the experimental group, there was a 3.6-fold reduction in average tumor volume compared to control mice, Akporiaye said.

In both preventive and therapeutic studies, mice fed alpha-TEA chow had a 4.8-fold reduction in the number of tumors that had spread to the lungs, compared to control mice. “The results were very impressive,” he said. “The chow was very effective in slowing down the growth rate of the tumor and significantly reducing metastases.”

The alpha-TEA diet produced no visible adverse side effects, not even weight loss, Akporiaye said.

“The combined characteristics of ease of delivery, relevance of route of delivery and selectivity for killing tumor cells suggest that dietary alpha-TEA may be useful for treating metastatic breast cancer,” he said.

The researchers are now testing the effect of reduced doses of alpha-TEA in the chow and plan to test the synthetic vitamin in combination with dendritic cell immunotherapy. “When you kill tumor cells, they release antigens that can be picked up by specialized cells that stimulate the immune system,, and this two-step process could provide a longer lasting outcome,” Akporiaye said.

Surce-Newswise
SRM
'"/>




Related medicine news :

1. Top Ten Super Food Items That Can Help In Avoiding Cancer
2. Top Ten Super Food Items That Can Help In Avoiding Cancer
3. Super Bugs Contaminate UK Chickens
4. Atypical Antibiotics For Super Bugs
5. Supercomputer Grid Enlists PCs To Combat AIDS
6. Amitabh Bachchan - India’s Superstar Undergoes Surgery
7. “Super Broccoli” Could Confer Better Cancer Protectin
8. Newer Generation Sleeping Pills Lack Superior Performance
9. The MRSA Superbug May Yet Be Overcome
10. Superbug Claims More Lives In Scotland
11. Little Clinic LLC Plans Super Medical Clinics in Publix Super Markets
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... FLA (PRWEB) , ... February 12, 2016 , ... Miami ... dental implants to their Miami dental office. Beginning in January, Miami Dental Specialists ... titanium. Miami Dental Specialists are the first office to be chosen by the dental ...
(Date:2/12/2016)... ... February 12, 2016 , ... Atlantic ... for Health Plans and PBMs,” an upcoming Feb. 24 webinar that will discuss ... in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis C treatment Sovaldi and ...
(Date:2/12/2016)... ... ... Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 to its annual Winter Teen Dance. ... and without special needs to gather in a safe and supportive environment. Volunteers will be ... place on Saturday, Feb. 13 from 7 to 9:30 p.m. at Elks Lodge, 322 Elks ...
(Date:2/12/2016)... ... February 12, 2016 , ... With the exception of restorative dentistry, to date there has ... With the recent approval by the FDA, there is a now a new protocol in ... SDF is very simple and quick to apply. The application is as simple as ...
(Date:2/11/2016)... ... February 11, 2016 , ... SPH Analytics announced ... analytics leader’s population health solutions, MDinsight® and IndiGO®, for its primary care clinicians. ... system. Details of the contract were not disclosed. , As the healthcare market ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... SEOUL, South Korea , Feb. ... Macrogen, Inc. today announced they will form a ... for precision medicine in cancer. The goal of ... digital-sorting technology with Macrogen,s high-throughput Next Generation Sequencing ... the Clinical Laboratory Improvement Amendments (CLIA) of 1988 ...
(Date:2/12/2016)... 2016  OMS Supply, a large provider of oral ... today the recent launching of their new company website. ... features that enhance the user experience and enable practitioners ... --> --> Despite the ... that started in early 2016, they have already made ...
(Date:2/12/2016)... BUDAPEST , Ungarn, February 12, 2016 ... ein Medizintechnikunternehmen, das sich auf den ungedeckten ... gab heute positive Ergebnisse seines klinischen Forschungsprogramms ... und Asthma-Patienten beschäftigt, ergab Verbesserungen ihrer respiratorischen ... Indiso ltd , ein Medizintechnikunternehmen, das ...
Breaking Medicine Technology: