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Suicide Gene Therapy Kills Bowel Cancer Cells

An innovative type of gene therapy has for the first time succeeded in making bowel cancer cells commit suicide, according to a report in Cancer Research this week.

The therapy, developed by Cancer Research UK-funded scientists at The Institute of Cancer Research, combines cutting-edge techniques to target tumour cells. Known as GDEPT (Gene-Directed Enzyme Prodrug Therapy), the treatment uses a virus to attack cancer cells.

But the researchers have added an extra gene to the virus. The virus is programmed to switch on the gene only if it reaches a tumour. When the gene is switched on, the virus produces a protein that activates an otherwise harmless prodrug, given separately.

Because this drug is only activated in tumours, it selectively kills only cancer cells. In normal tissue, the drug remains inactive, so healthy cells are not affected.

This is the first time such a therapy has proved successful at killing bowel cancer cells, albeit only in the laboratory. Cancer Research UK and The Institute of Cancer Research are supporting the development of the therapy, and hope to take it into early clinical trials in the future.

Lead researcher, Professor Caroline Springer of The Institutes Cancer Research UK Centre for Cancer Therapeutics, said: We have developed a smart method to selectively target cancer cells. Normal cells are spared because the virus doesnt produce the protein that activates the drug unless it is inside a tumour.

"The beauty of our approach is that the cancer cells are made to commit suicide both by the virus and the activated drug the two work in tandem. And once activated, the drug has the added bonus of causing the virus to produce more of the activating protein, which activates more of the drug, and so on. Its the first time weve seen a positive feedback loop like this in a GDEPT therapy."

The drug damages DNA inside the cancer cells to the point wh
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