Navigation Links
Suicide Gene Therapy Kills Bowel Cancer Cells

An innovative type of gene therapy has for the first time succeeded in making bowel cancer cells commit suicide, according to a report in Cancer Research this week.

The therapy, developed by Cancer Research UK-funded scientists at The Institute of Cancer Research, combines cutting-edge techniques to target tumour cells. Known as GDEPT (Gene-Directed Enzyme Prodrug Therapy), the treatment uses a virus to attack cancer cells.

But the researchers have added an extra gene to the virus. The virus is programmed to switch on the gene only if it reaches a tumour. When the gene is switched on, the virus produces a protein that activates an otherwise harmless prodrug, given separately.

Because this drug is only activated in tumours, it selectively kills only cancer cells. In normal tissue, the drug remains inactive, so healthy cells are not affected.

This is the first time such a therapy has proved successful at killing bowel cancer cells, albeit only in the laboratory. Cancer Research UK and The Institute of Cancer Research are supporting the development of the therapy, and hope to take it into early clinical trials in the future.

Lead researcher, Professor Caroline Springer of The Institutes Cancer Research UK Centre for Cancer Therapeutics, said: We have developed a smart method to selectively target cancer cells. Normal cells are spared because the virus doesnt produce the protein that activates the drug unless it is inside a tumour.

"The beauty of our approach is that the cancer cells are made to commit suicide both by the virus and the activated drug the two work in tandem. And once activated, the drug has the added bonus of causing the virus to produce more of the activating protein, which activates more of the drug, and so on. Its the first time weve seen a positive feedback loop like this in a GDEPT therapy."

The drug damages DNA inside the cancer cells to the point wh ere the cells stop functioning. They have no choice but to shut down and die.

Another benefit of the therapy is that it doesnt just kill only the cancer cells infected by the virus.

"We also see a significant 'bystander effect'," added Prof Springer. "This means the cells killed by the virus or the drug release signals into the tumour that tell neighbouring cancer cells to die too."

In lab experiments, mice with bowel tumours that received the therapy lived twice as long as those that did not. The researchers suggest their technique could one day be used as a treatment for advanced bowel cancer that doesnt respond to standard chemotherapy.

Professor John Toy, medical director of Cancer Research UK, said: "GDEPT therapy has been in development for several years. But this study shows the technique always a smart therapy is becoming ever more sophisticated. For the first time it has been shown to be effective at killing bowel cancer cells in a laboratory model of human colon cancer. This is another stride towards the possible use of GDEPT for cancer patients."


'"/>




Related medicine news :

1. Suicide risk in panic disorder
2. Suicide risk high in 12-17 Age Group
3. Suicide might be inherited
4. Suicide reduced by anti-depressants
5. Twins Less Prone to Suicide Than Others
6. Suicide Prevention Program – Having its Intended Effec
7. Anxiety Can Increase The Risk Of Attempting Suicide In Men
8. Suicide Rate Amongst Male Prisoners Of UK Is Quite High
9. Aspirin induces Cancer Cells To Commit Suicide
10. More Youth In Himachal Resort To Suicide
11. Group Suicides On The Rise In Japan
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... ... March 22, 2017 , ... The Carballo Agency, ... and the New York metropolitan region, is embarking on a cooperative charity drive ... , At present, more than two and a half million children in the ...
(Date:3/22/2017)... , ... March 22, 2017 , ... ... financial planning services to regional families and business owners, is joining the Teen ... young people in the area. , A growing number of Oklahoma teens and ...
(Date:3/22/2017)... Hilliard, OH (PRWEB) , ... March 22, 2017 ... ... that provides asset protection services and financial planning assistance to communities throughout central ... with Traumatic Brain Injuries. , Estimates from the Department of Defense and the ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... for providers while creating a positive patient experience. , HealthiPASS has further ... and empowers patients by helping them understand their financial responsibility. “Our latest ...
(Date:3/22/2017)... ... ... The National Association for Business Resources (NABR) has recently named ... Wellness® companies for 2017. , American Specialty Health (ASH) was honored for ... its employees. ASH is one of only nine other San Diego companies being recognized ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... LITTLE FALLS, N.J. , March 22, 2017  CANTEL ... Jorgen B. Hansen , President and CEO, will be ... Healthcare Conference at the Westin Grand Central Hotel in ... for Wednesday, April 5, 2017 at 3:00 p.m. ET. In ... the day. A live audio webcast will ...
(Date:3/22/2017)... , March 22, 2017 TapImmune, ... specializing in the development of innovative peptide and ... metastatic disease, today announced that it will participate ... Dr. Glynn Wilson , Chairman and ... the company,s business, clinical pipeline and partnering opportunities ...
(Date:3/22/2017)... , March 22, 2017 Hologic, Inc. (Nasdaq: ... completed the acquisition of Cynosure, Inc., a leader in ... in cash. "We are pleased to complete ... with Michael Davin and the entire Cynosure ... rapidly growing medical aesthetics market," said Steve MacMillan ...
Breaking Medicine Technology: