Navigation Links
Sugars in Liver Found to Clear Fats from the Bloodstream

Maybe you ate a big, juicy steak for dinner last night, adding a large amount of fat – scientifically known as triglycerides – to your system. For one in ten of us, that could be a big problem. //

Although we try to reduce fat in our diet, our bodies use it for energy. But patients with elevated levels of fat in their bloodstream – nearly 10 percent of Americans – are more likely to develop arthrosclerosis, or build-up of plaque in the arteries, which can lead to a heart attack or stroke.

In work with mice, researchers at the University of California, San Diego (UCSD) School of Medicine discovered a factor that could be responsible for many unexplained cases of elevated triglyceride levels.

In humans, this condition can be diabetes-related, diet-induced, or caused by drug interactions or chronic alcohol consumption. The problem can also run in families. But it turns out that another important factor is sugar – a complex one produced by all cells in the body called heparan sulfate, which is related to the anti-coagulant heparin.

The UCSD team found that heparan sulfate in the liver helps the body clear triglycerides from the blood. Their study, published in the January 1 issue of the Journal of Clinical Investigation, suggests that some patients with elevated triglyceride levels could have changes in heparan sulfate in the liver. The discovery could pave the way for new therapies for a major and growing medical problem.

“The work confirms that heparan sulfate in the liver plays a crucial role in clearing fat,” said Jeffrey D. Esko, Professor of Cellular and Molecular Medicine at UCSD’s School of Medicine. “These molecules clear triglycerides and cholesterol from the blood, working alongside the better known LDL receptors”

The UCSD researchers created a mouse model with a mutation of heparan sulfate, which resulted in elevated triglyceride levels, like those seen in many patients with diabetes. The r esearchers made mutations in only in the liver, because such mutations throughout all tissues would lead to the death of an embryo or death shortly after birth.

“By selectively mutating a single tissue in mice, in this case the liver, we avoided a lethal effect,” said Esko. In the lab, the researchers combined the heparan sulfate mutation with a mutation in the LDL receptor, which has long known to be responsible for clearing cholesterol from the arteries. The UCSD team showed that heparan sulfate is involved in clearing not only triglycerides, but also cholesterol, from the blood.

“The finding, that the LDL receptor plus heparan sulfate work together to clear triglyceride and cholesterol-rich particles from the blood in a healthy person is very exciting,” Esko said. The study suggests the possibility that mutations in one of 40 or so genes involved in production of heparan sulfate in the liver could result in high blood-fat levels and lead to complications such as arthrosclerosis, according to Esko.

In animal models with induced diabetes, changes in liver heparan sulfate – consistent with the UCSD researchers’ findings – often appear. One of the team’s next steps will be to induce diabetes in animals and examine the role of heparan sulfate in more detail.

“Such studies could lead to new drugs that change heparan sulfate in order to lower fat levels in patients,” said Esko.

Souce-Newswise
SRM
'"/>




Related medicine news :

1. Sugars Could Contain Key Cancer Inhibiting Compounds
2. Blood Cells Capable of Regenerating Liver
3. Liver donors can thrive after transplant
4. Heavy Drinking Raises Risk of Liver Cancer
5. Arthritis Drug May Cause Liver Damage
6. Liver transplant oversight urged
7. Liver key to extending life
8. Liver cancers which spread are linked to a particular gene
9. Liver diseases: The enemy with an accomplice
10. Troubled Childhood found to affect your Liver
11. New Liver Tumor Treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/18/2017)... ... August 18, 2017 , ... Mediaplanet today ... for active, healthy lifestyles and highlighting the importance of proactive eye and ear ... and shares the latest innovations in hearing aid technology. , In this ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh & ... assistance to communities in North-Central West Virginia, is embarking on a cooperative charity ... in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding ...
(Date:8/18/2017)... Humble, TX (PRWEB) , ... August 18, 2017 ... ... insurance management and financial planning firm that serves residential and commercial clients in ... a charity drive to raise community support for the fight against cancer. , ...
(Date:8/18/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has released ... pertaining to the mother of the Savior whom the world calls “Mother Mary”. Yisrayl says ... the role of this historical woman. , “The world bows, kisses the feet of, ...
(Date:8/18/2017)... ... , ... “Our Mountains to Climb: A Journey of Love and Faith Through ... through the faith they shared to overcome struggles in life. “Our Mountains to Climb: ... Barbara J. Corcoran, a retired teacher and happily married since 1999; the author’s personal ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... CaryRx, a next-generation full-service pharmacy, has announced the ... in the Washington D.C. metropolitan area. ... delivery of medications through the convenience of its patient-friendly mobile ... within one hour to any location in D.C. ... invaluable service to Washington D.C. ," says ...
(Date:7/28/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today announced financial results ... and updated its financial outlook for fiscal 2017. ... third quarter, Hill-Rom reported earnings of $0.09 per diluted ... prior-year period. These results reflect after-tax special items, including ... to the non-cash write-down of assets associated with the ...
(Date:7/26/2017)... Aesthetics, a leading medical aesthetic clinic in Singapore ... skin conditions from the inside. The natural process of ... skin becomes more transparent due to the thinning of the epidermis. Over ... the sun contributes to aging skin, causing age spots and other ... ...
Breaking Medicine Technology: