Navigation Links
Success of Hip Replacement Surgery Decided by Genes

Research suggests that genes responsible for generating matrix metalloproteinase 1 and vitamin D synthesis may determine the success// of long term hip replacement surgery.

The researchers analysed genetic variations in 312 people, just over half of whom (162) had problems after hip replacement in the 10 years following surgery.

Among those with symptoms, 91 had early signs of 'aseptic loosening,' which describes a condition in which the artificial joint comes loose and the surrounding bone begins to dissolve. The other 71 patients had deep-seated infection, which occurs when the body is unable to control infection caused by bacteria colonising the artificial implants.

DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis.

MMP1 is an enzyme that breaks down collagen, the main protein found in bone and cartilage, while interleukin 6 is a chemical involved in bone metabolism and the immune response.

Vitamin D synthesis is important for strong healthy bones.

Variations in the interleukin 6 gene did not seem to have any effect. But those with variations in MMP1 were more than three times as likely to have aseptic loosening as those who did not carry the genetic variation.

And variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.

The authors conclude that if confirmed in other research, these findings could be used to predict long term success in patients undergoing hip replacement surgery. And they could also be used to develop targeted genetic treatments.

Source-Eurekalert
PRI
'"/>




Page: 1

Related medicine news :

1. Plastic Sling Has Proved Successful In Improving Aging Of The Neck
2. Does Success in School Differ From the Real World Success ?
3. The Success Rate Of Angioplasty In Female Patients Low
4. Success of HIV may depend in its mutations
5. Success Of Preventable High-Risk HPV Infections With Vaccines May Vary
6. Successful creation of human embryos from a single parent for the first time
7. Fertility Treatment Offered During Summer Has Better Chances For Success
8. Happiness Plays An Important Role In Success
9. French Doctors Successfully Separate Twins Joined At Spine
10. Alzheimer’s disease trial With EVT 101 For Successfully Complete
11. Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... , ... Pixel Film Studios brings the spirit of the holiday season to ... of the ProDrop series. Pick and choose from 30 unique designs inspired by the ... using ProDrop's wintry generators. ProDrop Christmas is a Final Cut Pro X exclusive. ...
(Date:2/11/2016)... D.C. (PRWEB) , ... February 11, 2016 , ... ... will be exhibiting at the American Academy of Dermatology Annual Meeting at the ... USA's goal is to raise awareness for both the condition of hyperhidrosis (excessive ...
(Date:2/11/2016)... San Diego, CA (PRWEB) , ... February 11, 2016 , ... ... Combine which was held in San Diego, CA, on February 6th & 7th, 2016 ... NFL combine for those who were not invited to the NFL’s combine in Indianapolis,” ...
(Date:2/11/2016)... ... 11, 2016 , ... The book, “Computers Should Just Work!”, provides a basic, ... your IT consultant before signing a contract and how to spot an incompetent or ... relying heavily on e-mail and technology, it’s more important than ever to make sure ...
(Date:2/11/2016)... ... February 11, 2016 , ... As part of their 2015 end of ... Round Table Foundation (MDRTF), has gifted $10,000 to University of Chicago to support ovarian ... Billy Cundiff. , “We are honored to support a promising young investigator from Dr. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Korea , Feb. 11, 2016 Wearable posture tracker, ALEX , has taken Kickstarter ... funded and just seven days left to go, ALEX is said to be delivered to backers starting ... ... ... Created ...
(Date:2/11/2016)... INDIANAPOLIS , Feb. 11, 2016  Attending ... but for those with type 1 diabetes, the journey ... juggle class schedules, assignments and campus activities, they also ... diabetes. On top of that, many are living away ... Scholars Foundation (Foundation) Lilly Diabetes Tomorrow,s Leaders Scholarship ...
(Date:2/11/2016)... 11, 2016  AbbVie, a global biopharmaceutical company, ... designed to provide financial support for exceptional students ... higher education goals. Fifteen scholars will be selected ... year. The AbbVie Rheumatology Scholarship is currently accepting ... president, corporate social responsibility, brand and communications, AbbVie. ...
Breaking Medicine Technology: