Navigation Links
Success of Hip Replacement Surgery Decided by Genes

Research suggests that genes responsible for generating matrix metalloproteinase 1 and vitamin D synthesis may determine the success// of long term hip replacement surgery.

The researchers analysed genetic variations in 312 people, just over half of whom (162) had problems after hip replacement in the 10 years following surgery.

Among those with symptoms, 91 had early signs of 'aseptic loosening,' which describes a condition in which the artificial joint comes loose and the surrounding bone begins to dissolve. The other 71 patients had deep-seated infection, which occurs when the body is unable to control infection caused by bacteria colonising the artificial implants.

DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis.

MMP1 is an enzyme that breaks down collagen, the main protein found in bone and cartilage, while interleukin 6 is a chemical involved in bone metabolism and the immune response.

Vitamin D synthesis is important for strong healthy bones.

Variations in the interleukin 6 gene did not seem to have any effect. But those with variations in MMP1 were more than three times as likely to have aseptic loosening as those who did not carry the genetic variation.

And variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.

The authors conclude that if confirmed in other research, these findings could be used to predict long term success in patients undergoing hip replacement surgery. And they could also be used to develop targeted genetic treatments.

Source-Eurekalert
PRI
'"/>




Page: 1

Related medicine news :

1. Plastic Sling Has Proved Successful In Improving Aging Of The Neck
2. Does Success in School Differ From the Real World Success ?
3. The Success Rate Of Angioplasty In Female Patients Low
4. Success of HIV may depend in its mutations
5. Success Of Preventable High-Risk HPV Infections With Vaccines May Vary
6. Successful creation of human embryos from a single parent for the first time
7. Fertility Treatment Offered During Summer Has Better Chances For Success
8. Happiness Plays An Important Role In Success
9. French Doctors Successfully Separate Twins Joined At Spine
10. Alzheimer’s disease trial With EVT 101 For Successfully Complete
11. Switching Off Protein Could Play Key Role In Success Of Radiation Therapy For Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Success Hip Replacement Surgery Decided Genes

(Date:4/24/2015)... Carvers' goal is to help an ... day in Breck. , Conveniently located in the ... from Breckenridge, this family-owned place since 1995, has ... rentals ( http://www.breckenridgeskishop.com/en/rent-equipment ) and more. , ... in May 2015. With style and function progressing ...
(Date:4/24/2015)... 24, 2015 On February 21st, 2015, ... an interview with ItsNotAboutMe.TV contributor Karen Salkin at Durkin ... treatment center for addiction, of which Wickstrom is the ... throughout the year, the EcoLuxe Lounge is a gathering ... and socially conscious products and services. Among the many ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
(Date:4/24/2015)... Joseph, Missouri (PRWEB) April 24, 2015 ... for veterinarians , UGA is now proud to be ... the care of 16,000 animals a year. This partnership ... care for their animals. , After providing an ... Missouri Veterinary Medical Teaching Hospital (VMTH) wanted to increase ...
(Date:4/24/2015)... “ Opera ” was featured on NewsWatch as part of ... technology products available to consumers. Andrew Tropeano, a technology expert ... with viewers how this is the fastest way to surf ... not be in existence. But each web browser is slightly ... different. Celebrating their 20th anniversary this year, Opera connects over ...
Breaking Medicine News(10 mins):Health News:Carvers Breckenridge Bike Rentals Offers Demo Mountain, Tandem, Bike Path Cruiser & JR. Bikes in May 2015 2Health News:Karen Salkin Talks with Per Wickstrom at the 2015 EcoLuxe Lounge and the "Salute to the Oscars" Celebration 2Health News:University of Missouri Veterinary Medical Teaching Hospital Teams with UGA 2Health News:A Web Browser That Connects over 350 Million People was Featured on NewsWatch Television 2
... irregularities are at greater risk of heart-rhythm abnormality: study ... who have severe sleep-related breathing problems are at increased ... , The study included 2,911 men who underwent sleep ... episodes of paused or shallow breathing during sleep were ...
... (NYSE: HGR ) announced today that it plans to ... the second quarter ending June 30, 2009, on Tuesday, July 28, ... The conference call is scheduled to begin at 9:00 a.m., EDT, ... 1-800-931-9710. In addition, a replay will be available until August 5, ...
... U.S. patent infringement lawsuit was filed on June 10, ... America, Inc. The lawsuit, brought by Aperio Technologies, ... of Delaware, accuses products incorporating Hamamatsu Photonics K.K. NanoZoomer(R) ... and 7,518,652. , , The lawsuit follows a ...
... YORK, June 23 FamilyCord , one of ... their title sponsorship of the WBLI 106.1 Baby Shower event where ... for a day of fun, prizes, and education on June 28. ... storing cord blood to protect newborns against 70 life-threatening diseases. Leading ...
... June 23 The National Medical Association (NMA) congratulates President ... their work with PhRMA to bring down health care costs ... the adoption of Medicare Part D has been a tremendous ... the system," said Dr. Mohammad N. Akhter, Executive Director of ...
, Journalists and other readers should disregard the news release, PHT Names VP to Lead Sales of A-Claim Payment Solution for Doctors, Hospitals, issued 23-Jun-2009. The release was transmitted prema...
Cached Medicine News:Health News:Sleep Disorders Linked to Arrhythmias 2Health News:U.S. Patent Infringement Lawsuit Filed by Aperio Technologies, Inc. 2
(Date:4/24/2015)... Introduction of new ... tools for radiosurgery/SBRT   The "Elements" ... enhancing the workflow for difficult to treat indications ... - comes full circle with the introduction of ... Elements enable on-the-fly generation of consistent treatment plans ...
(Date:4/24/2015)... , April 24, 2015 /CNW/ - T-Bird Pharma Inc. ... on developing premium quality medical marijuana products and a ... for Medical Purposes Regulations ( Canada ) ... certain of its shareholders, has closed the transaction announced ... Medna has acquired (the "Escrow Transfer") a total of ...
(Date:4/23/2015)... Lifesciences Corporation (NYSE: EW ), the global leader ... today reported net income for the quarter ended March 31, ... Net income for the same period a year earlier ... non-GAAP net income was $82.1 million, or $0.76 per ... ended March 31, 2015 increased 13.0 percent to $590.3 million ...
Breaking Medicine Technology:Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16
... 2011 Pennsylvania Association of Medical Suppliers (PAMS) ... Thompson (R-Centre) and Jason Altmire, (D-Allegheny) that would ... medical equipment.  H.R. 1041, titled the "Fairness in ... patient groups and consumer organizations, including the Three ...
... ViroPharma Incorporated (Nasdaq: VPHM ) today ... Use (CHMP) of the European Medicines Agency (EMA) has ... March 2011 recommending approval of a Centralized Marketing Authorization ... with hereditary angioedema (HAE) for routine prevention, pre-procedure prevention ...
Cached Medicine Technology:Bi-Partisan Legislation Introduced Would Repeal Controversial Medicare 'Competitive Bidding' Requirements for Home Medical Equipment 2Bi-Partisan Legislation Introduced Would Repeal Controversial Medicare 'Competitive Bidding' Requirements for Home Medical Equipment 3Bi-Partisan Legislation Introduced Would Repeal Controversial Medicare 'Competitive Bidding' Requirements for Home Medical Equipment 4ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 2ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 3ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 4ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 5ViroPharma Announces Positive CHMP Opinion for Cinryze® (C1 Inhibitor [Human]) in European Union 6
Suspend® Tutoplast® Processed Fascia Lata is your naturally safe and strong choice for pelvic floor reconstruction. Suspend comes from a dense matrix of collagen bundles and transverse fasc...
... Bard® Dermal Allograft ... of most pelvic floor ... highly resistant to suture ... and serves as a ...
... Viral RNA Mini Kit allows ... from cell-free fluid samples. Examples ... can be isolated with this ... limited to, RNA from hepatitis ...
The PersonalLAB junior is an automated microplate analyzer capable of fully automating immunoenzymatic techniques using a microplate format, per the reagent manufacturer's instruction for use and spe...
Medicine Products: