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Study to Investigate Gene's Effect on Bone Loss in Breast Cancer Patients

itors. This study is an example of how physicians hope to use a patient's genetic code to create personalized treatment.

"As more breast cancer patients use these drugs, more may be expected to experience osteoporotic (porous bone) complications," Villareal says. "We are attempting to address this issue to identify those that would need early intervention to prevent bone loss with aromatase inhibitor therapy."

Postmenopausal women with breast cancer are eligible to participate. The researchers will compare bone loss in women taking aromatase inhibitors to those not using these drugs, so both groups are wanted for the study. The study will not require participants to alter their cancer treatment.

Participants will receive free bone density scans and will be tested for blood markers that indicate bone turnover. Each volunteer will be genotyped for CYP19 variants to investigate any link between genetic profile and bone loss.


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