Navigation Links
Study to Investigate Gene's Effect on Bone Loss in Breast Cancer Patients

Women with estrogen-responsive breast cancer are often prescribed a drug that reduces their estrogen levels. But because estrogen is important to bone health, there is widespread concern about how the estrogen-reducing drugs - called aromatase inhibitors - affect bones.

A study at Washington University School of Medicine in St. Louis will investigate bone loss in women taking aromatase inhibitors, and researchers are calling for interested women to volunteer.

Aromatase is an enzyme that transforms testosterone and other androgens into estrogen. This process represents the major, if not only, source of estrogen in postmenopausal women. So giving women aromatase inhibitors can result in nearly complete shutdown of estrogen production, which can have unwanted side effects.

"There are reports of an increased incidence of fractures in women on aromatase inhibitors," says Reina Armamento-Villareal, M.D., assistant professor of medicine in the Division of Bone and Mineral Diseases and a Washington University bone specialist at Barnes-Jewish Hospital. "But interestingly, studies show that women respond differently to these drugs, possibly because of variations in the gene that produces the aromatase enzyme."

This gene is CYP19. Scientists have identified several variations of CYP19 that can result in either increased or decreased aromatase activity. This in turn influences how aromatase inhibitors affect estrogen levels. The Washington University study will analyze the sequence of the CYP19 gene in volunteers to see which variation they possess.

"Our hypothesis is that the use of aromatase inhibitors can be associated with significant bone loss, and the degree of bone loss will be related to the variations of the CYP19 gene," Villareal says.

The data the researchers collect from the study will aid in establishing the appropriate approach to maintaining bone health in women who are given aromatase inhib
'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Investigate Gene Effect Bone Loss Breast Cancer Patients

(Date:8/29/2015)... ... August 29, 2015 , ... "I have been ... Place, N.Y. "I specialize in manual therapy, and my invention will provide headache ... used for additional muscle dysfunction throughout the body." , They developed THE RELIEVER ...
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day weekend, the ... ends on September 22nd this year). For IT security personnel, it should also mark ... could prove far more costly than a simple headache. , Joe Caruso, founder and ...
(Date:8/29/2015)... TX (PRWEB) , ... August 29, 2015 , ... ... allows the company to freely market and sell Arterosil and Arterosil HP, and ... Health Sciences, LLC (DHS) sued Vascular Health Sciences, LLC (VHS) in the United ...
(Date:8/28/2015)... ... August 28, 2015 , ... The Kentucky State Department of ... for the position they are applying for, they are unable to pass the initial ... considering altering drug testing policies in order to be able to hire long-term, skilled ...
(Date:8/28/2015)... ... , ... As reported by Medical Daily on August 22 , Cellfina, ... last for two years, the longest of any cellulite reduction system currently on the ... long-lasting, effective solution for their cellulite, according to Dr. Robert Weiss, director of the ...
Breaking Medicine News(10 mins):Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3
... Newest Auction Campaign of Upscale Properties in Denver, Colorado , ... ... online real estate auction marketing firm, LFC Group of Companies, launched ... on its residential real estate website, Freedom Realty Exchange ( FRE.com/284R3 ...
... A proven and widely adopted research informatics ... with the implementation at a world-class multidisciplinary ... the University of Wisconsin Institute for Clinical ... to handle their clinical research data collection ...
... a new study from the Centers for Disease Control ... 5.5 million in 2005 to 16 million in 2050, ... of blindness in working-age people. The CDC study ... that is motivating ophthalmic research around the globe. Hideharu ...
... foods consumed during pregnancy might protect against asthma and ... apple a day while you,re pregnant may indeed keep ... your unborn child. , Recent research suggests ... have lower rates of asthma. , And, mothers who ...
... than vitamin supplementation. , ... Phoenix, AZ (Vocus) January ... of the National Cancer Institute confirmed that vitamin supplementation provided no ... on the heels of numerous studies which all draw the same ...
... The National Parkinson Foundation (NPF) awarded five grants ... interventions aimed at preventing falls in people with ... five different research projects at NPF Centers of ... United States. NPF supports a strong network ...
Cached Medicine News:Health News:Let the Bidding Begin in Online Auction of Denver Luxury Homes 2Health News:Let the Bidding Begin in Online Auction of Denver Luxury Homes 3Health News:Let the Bidding Begin in Online Auction of Denver Luxury Homes 4Health News:OnCore System Supporting Research Informatics Needs of the University of Wisconsin's Institute for Clinical and Translational Research 2Health News:OnCore System Supporting Research Informatics Needs of the University of Wisconsin's Institute for Clinical and Translational Research 3Health News:OnCore System Supporting Research Informatics Needs of the University of Wisconsin's Institute for Clinical and Translational Research 4Health News:Ophthalmology highlights Jan. 2009 2Health News:Prenatal Nutrition, Postnatal Allergy Protection 2Health News:Prenatal Nutrition, Postnatal Allergy Protection 3Health News:Treadmill Desks More Effective in Cancer Prevention for Women than Vitamin C, E and Beta Carotene Supplementation 2Health News:Treadmill Desks More Effective in Cancer Prevention for Women than Vitamin C, E and Beta Carotene Supplementation 3Health News:The National Parkinson Foundation Awards Five Grants for the Falls Prevention Initiative 2Health News:The National Parkinson Foundation Awards Five Grants for the Falls Prevention Initiative 3
(Date:8/28/2015)... 2015 Research and ... of the "Investigation Report on China,s Pranoprofen ... Originally discovered by Welfide (Mitsubishi Tanabe Pharma ... as an inflammatory drug, pranoprofen was later developed ... under the trade name of pranopulin for the ...
(Date:8/28/2015)... WARRENVILLE, Ill. , Aug. 28, 2015 /PRNewswire/ ... Patterson Companies, Inc. (Nasdaq: PDCO ), is ... the previously announced acquisition of Patterson Medical by ... Medical will retain its name for a transition ... distributor of rehabilitation and sports medicine products.  With ...
(Date:8/28/2015)... HONG KONG , August 28, 2015 ... Gero in collaboration with one of the leading academics ... Reis (current world record holder in life extension for ... new insights into biology of aging and age-related diseases, primarily, ... networks. The work has just been published as "Stability analysis ...
Breaking Medicine Technology:Investigation Report on China's Pranoprofen Market, 2010-2019 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3
... , RIDGEFIELD, Conn., Aug. 25 ... Long-Term Anticoagulant Therapy, Warfarin, Compared to Dabigatran)(1) study will be ... Barcelona on Sunday, Aug. 30. The primary objective of ... investigational oral direct thrombin inhibitor, dabigatran etexilate, against the current ...
... NINOVE, Belgium, August 25 20% of parents ... food) of their baby,and the accompanying discomfort (crying). Reputed ... Medical Journal" group recently,published the results of the clinical ... the Children,s gastroenterology department of the Brussels,University Hospital. , ...
Cached Medicine Technology:Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 2Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 3Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 4Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 5Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 6Data From Largest Stroke Prevention Trial in Atrial Fibrillation To Premiere at European Society of Cardiology Congress 7Medical World Recognises New Therapy for Reflux Babies 2
Disposable tracheostomy care tray....
Disposable tracheostomy care tray....
Disposable tracheostomy care tray....
Disposable tracheostomy care tray....
Medicine Products: