Navigation Links
Study to Investigate Gene's Effect on Bone Loss in Breast Cancer Patients

Women with estrogen-responsive breast cancer are often prescribed a drug that reduces their estrogen levels. But because estrogen is important to bone health, there is widespread concern about how the estrogen-reducing drugs - called aromatase inhibitors - affect bones.

A study at Washington University School of Medicine in St. Louis will investigate bone loss in women taking aromatase inhibitors, and researchers are calling for interested women to volunteer.

Aromatase is an enzyme that transforms testosterone and other androgens into estrogen. This process represents the major, if not only, source of estrogen in postmenopausal women. So giving women aromatase inhibitors can result in nearly complete shutdown of estrogen production, which can have unwanted side effects.

"There are reports of an increased incidence of fractures in women on aromatase inhibitors," says Reina Armamento-Villareal, M.D., assistant professor of medicine in the Division of Bone and Mineral Diseases and a Washington University bone specialist at Barnes-Jewish Hospital. "But interestingly, studies show that women respond differently to these drugs, possibly because of variations in the gene that produces the aromatase enzyme."

This gene is CYP19. Scientists have identified several variations of CYP19 that can result in either increased or decreased aromatase activity. This in turn influences how aromatase inhibitors affect estrogen levels. The Washington University study will analyze the sequence of the CYP19 gene in volunteers to see which variation they possess.

"Our hypothesis is that the use of aromatase inhibitors can be associated with significant bone loss, and the degree of bone loss will be related to the variations of the CYP19 gene," Villareal says.

The data the researchers collect from the study will aid in establishing the appropriate approach to maintaining bone health in women who are given aromatase inhib itors. This study is an example of how physicians hope to use a patient's genetic code to create personalized treatment.

"As more breast cancer patients use these drugs, more may be expected to experience osteoporotic (porous bone) complications," Villareal says. "We are attempting to address this issue to identify those that would need early intervention to prevent bone loss with aromatase inhibitor therapy."

Postmenopausal women with breast cancer are eligible to participate. The researchers will compare bone loss in women taking aromatase inhibitors to those not using these drugs, so both groups are wanted for the study. The study will not require participants to alter their cancer treatment.

Participants will receive free bone density scans and will be tested for blood markers that indicate bone turnover. Each volunteer will be genotyped for CYP19 variants to investigate any link between genetic profile and bone loss.


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes ... of the facility as part of a disaster drill on October 3rd. , Apple ... Shelton City Emergency Manager, as well as the Connecticut Long Term Care Mutual ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
Breaking Medicine Technology: