Navigation Links
Study of Bacterial Pathogen may Give Insight to Cancer Development

US researchers are conducting a study to understand the mechanism by which cells grow and cancer develops, and they are using the bacterial pathogen Listeria Monocytogenes in their project.

The research team, which includes University of Central Florida Microbiology Professor Keith Ireton, had recently found that a Listeria protein called InlB induces internalisation and degradation of a human receptor known as Met, which has been implicated in the development of some cancers.

Ireton worked with Lisa A. Elferink of the University of Texas Medical Branch, who led the study study published in the Journal of Biological Chemistry this month. They found that the ability of InlB to induce Met internalisation and degradation requires a human protein called Cbl.

The researchers feel that the knowledge of how to control Cbl may lead to the development of drugs that induce the destruction of Met, and are useful in treating Met-related cancers.

'We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into ingesting bacteria,' said Ireton, an expert on Listeria monocytogenes, a cause of food poisoning.

'When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the bacterium. We discovered that a human protein called CrkII plays a critical role in stimulating internalisation of Listeria by somehow controlling the cytoskeleton,' adds the researcher, who explains the mechanism in this months issue of the journal Cellular Microbiology.

Listeria is a potentially deadly pathogen, causing abortions in pregnant women and meningitis in those with compromised immune systems, resulting in about a 25 per cent mortality rate.

The findings are significant with a view to understanding and controlling the spread of bacteria that are a cause of potentially fatal food poisoning.

According to Ireton, the bacteria can live outside animal hosts, and its sources include dead plant matter, fruits and vegetables, unpasteurized diary products, and meats that have not been properly cooked.

Pregnant women and people with compromised immune systems are particularly susceptible.

Ireton suggests that contamination can be avoided by cooking all meats thoroughly, avoiding dairy products that are not pasteurised, and washing all fruits and vegetables thoroughly before consumption.


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... 2016 , ... David J. Dykeman , Ginger Pigott , and ... speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in California. ... firm’s global Life Sciences & Medical Technology Group have been featured speakers at every ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims ... employees that are both engaging and easy to use. Coming off the heels ... company revealed today its plans to roll out new AI-powered self-service enhancements to ...
(Date:12/8/2016)... ... December 08, 2016 , ... Catalent Pharma ... drugs, biologics and consumer health products, today announced that it had joined the ... as a non-profit organization to unite pharmaceutical and healthcare companies that share a ...
(Date:12/8/2016)... Dallas, TX (PRWEB) , ... December 08, 2016 , ... ... to continue to be a convenient service for Texas, they are expanding their presence ... will involve a hiring spree that will bring new jobs to the Dallas and ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are ... this in mind, SIGVARIS has created a new line of anti-embolism stockings to ... and provide the benefits of graduated compression when transitioning from recovery to early ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Valeant Pharmaceuticals ... TSX: VRX) ("Valeant") today announced positive results from ... study to assess the safety and efficacy of ... treatment of plaque psoriasis. Within ... with moderate to severe psoriasis, IDP-118 showed statistical ...
(Date:12/8/2016)... Mass. , Dec. 8, 2016  EIP ... it has obtained proof-of-mechanism for neflamapimod (previously code ... completed Phase 2a clinical trials that demonstrated significant ... Study 302 (12-week treatment) and Study 303 (6-week ... Clinical Trials in Alzheimer,s Disease (CTAD) scientific conference ...
(Date:12/8/2016)... , Dec. 8, 2016 A Small ... the National Institutes of Health (NIH) to ... University.  The grant will seek to ... head device, which utilizes electromagnetic waves to treat Alzheimer,s ... this novel technology to possibly treat other neurologic disorders ...
Breaking Medicine Technology: