Navigation Links
Study of Bacterial Pathogen may Give Insight to Cancer Development

US researchers are conducting a study to understand the mechanism by which cells grow and cancer develops, and they are using the bacterial pathogen Listeria Monocytogenes in their project.

The research team, which includes University of Central Florida Microbiology Professor Keith Ireton, had recently found that a Listeria protein called InlB induces internalisation and degradation of a human receptor known as Met, which has been implicated in the development of some cancers.

Ireton worked with Lisa A. Elferink of the University of Texas Medical Branch, who led the study study published in the Journal of Biological Chemistry this month. They found that the ability of InlB to induce Met internalisation and degradation requires a human protein called Cbl.

The researchers feel that the knowledge of how to control Cbl may lead to the development of drugs that induce the destruction of Met, and are useful in treating Met-related cancers.

'We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into ingesting bacteria,' said Ireton, an expert on Listeria monocytogenes, a cause of food poisoning.

'When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the bacterium. We discovered that a human protein called CrkII plays a critical role in stimulating internalisation of Listeria by somehow controlling the cytoskeleton,' adds the researcher, who explains the mechanism in this months issue of the journal Cellular Microbiology.

Listeria is a potentially deadly pathogen, causing abortions in pregnant women and meningitis in those with compromised immune systems, resulting in about a 25 per cent mortality rate.

The findings are significant with a view to understanding and controlling the spread of bacteria that are a cause of potentially fatal food poisoning.

According to Ireton, the bacteria can live outside animal hosts, and its sources include dead plant matter, fruits and vegetables, unpasteurized diary products, and meats that have not been properly cooked.

Pregnant women and people with compromised immune systems are particularly susceptible.

Ireton suggests that contamination can be avoided by cooking all meats thoroughly, avoiding dairy products that are not pasteurised, and washing all fruits and vegetables thoroughly before consumption.


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA ... the Road To Recovery® program to drive cancer patients to and from their cancer ... ensure the highest quality of life and ongoing independence. Getting to and from ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
(Date:6/24/2016)... ... 24, 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. ... service members that have been wounded in battle and their families. Venture Construction Group ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: