Navigation Links
Study of Bacterial Pathogen may Give Insight to Cancer Development

US researchers are conducting a study to understand the mechanism by which cells grow and cancer develops, and they are using the bacterial pathogen Listeria Monocytogenes in their project.

The research team, which includes University of Central Florida Microbiology Professor Keith Ireton, had recently found that a Listeria protein called InlB induces internalisation and degradation of a human receptor known as Met, which has been implicated in the development of some cancers.

Ireton worked with Lisa A. Elferink of the University of Texas Medical Branch, who led the study study published in the Journal of Biological Chemistry this month. They found that the ability of InlB to induce Met internalisation and degradation requires a human protein called Cbl.

The researchers feel that the knowledge of how to control Cbl may lead to the development of drugs that induce the destruction of Met, and are useful in treating Met-related cancers.

'We found that Listeria actually provokes human epithelial cells (cells lining the small intestine) into ingesting bacteria,' said Ireton, an expert on Listeria monocytogenes, a cause of food poisoning.

'When Listeria contacts an epithelial cell, the bacterium causes changes in the cells cytoskeleton that allow the cell to swallow up the bacterium. We discovered that a human protein called CrkII plays a critical role in stimulating internalisation of Listeria by somehow controlling the cytoskeleton,' adds the researcher, who explains the mechanism in this months issue of the journal Cellular Microbiology.

Listeria is a potentially deadly pathogen, causing abortions in pregnant women and meningitis in those with compromised immune systems, resulting in about a 25 per cent mortality rate.

The findings are significant with a view to understanding and controlling the spread of bacteria that are a cause of potentially fatal food poisoning.

According to Ireton, the bacteria can live outside animal hosts, and its sources include dead plant matter, fruits and vegetables, unpasteurized diary products, and meats that have not been properly cooked.

Pregnant women and people with compromised immune systems are particularly susceptible.

Ireton suggests that contamination can be avoided by cooking all meats thoroughly, avoiding dairy products that are not pasteurised, and washing all fruits and vegetables thoroughly before consumption.


Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:

(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. ... big data solutions, today announced that its MyDario product is expected to ... TV listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, ... ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
Breaking Medicine Technology: