Navigation Links
Study Would Pave Way for the Development of New Drugs That Targets TB Proteasome

A new study was conducted to understand the biochemistry and structure of a protein-cleaving complex (proteasome) that is essential to the TB bacterium’s survival. The findings were published in the journal Molecular Microbiology. // The study’s main aim was to design effective treatment for the disease tuberculosis (TB). The study was done by scientists from the U.S. Department of Energy’s Brookhaven National Laboratory and collaborating institutions. Biophysicist Huilin Li, who led Brookhaven’s role in the research, said that the study also plans to analyze the difference present in the structure and biochemistry of the TB bacterial proteasome from those found in human cells. This would greatly improve prospects for developing specific proteasome-based anti-tuberculosis treatments.

Mycobacterium tuberculosis is the bacterium that causes TB in man. Statistics show that one out of three people is infected with the disease. Largely the infected person is not aware of the presence of the disease as it does not manifest any observable symptoms. This is due to the fact that the bacteria is kept in check within immune system cells known as macrophages by compounds such as nitric oxide that kills or disables most of the bacteria. Inside the macrophage the immune cells damages and destroys the bacterial proteins. These accumulated proteins have to be removed otherwise it will in turn destroy the cell.

But the TB bacteria remove the damaged proteins with the help of a protein-cleaving complex known as a proteasome. It is highly specific for degrading protein parts. This protein allows Mycobacterium tuberculosis to remain in macrophages, and possibly go on to cause active TB infections. Hence Li said this protein should be made as a major target for the production of new anti-TB drugs. By this technique TB microbes can be eradicated from infected individuals who show no signs of infection. But the major drawback is that human cells also contain proteaso
'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
(Date:1/23/2015)... Phoenix, AZ (PRWEB) January 23, 2015 Hastings ... personal injury matters, reports a record number of legal representation ... Statistically speaking, there has been a steady rise in the ... at work and at home throughout the Valley. With that ... their accident be reviewed by an experienced law firm. Hastings ...
(Date:1/22/2015)... January 22, 2015 Liberty University has received ... program from the Council for Accreditation of Counseling ... of Liberty’s Center for Counseling & Family Studies , ... of the university’s new School of Behavioral Sciences. Prior to ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort ... as the number one best large hotel for families in ... for their annual Travelers’ Choice Awards. , TripAdvisor represents ... is home to millions of unbiased and honest traveler reviews. ...
(Date:1/22/2015)... is a seasoned and trusted leader who consistently delivers trendy ... have it lead the wedding dress industry into the future. ... for the global market. , “The CEO of VogueQueen is ... on continuing the goal of operational excellence and giving back ...
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2
... 26 (HealthDay News) -- If you,re told that your child ... carefully consider the situation, advises an expert. "Take ... respond defensively with ,not my child., Understand that your child ... health services at Saint Joseph,s University in Philadelphia, said in ...
... high body mass index (BMI) between 9 and 12 years of ... blood insulin levels (all risk factors for developing heart disease) by ... bmj.com today. Reassuringly, say the authors, children with ... reach adolescence have better heart disease risk profiles than those who ...
... Mammals began to grow much larger after dinosaurs became extinct ... international team of researchers analyzed the fossils of major groups ... size increased from a maximum of about 10 kilograms (22 ... maximum of 17 tonnes (18.7 U.S. tons) after dinosaurs became ...
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, ... who took a popular class of heartburn drugs while ... heightened risk of birth defects, a large Danish study ... inhibitors (PPIs), include blockbusters such as Prilosec (omeprazole), Prevacid ...
... outbreaks in refugee camps in earthquake-wracked Haiti, a group ... University, and the International Vaccine Institute (IVI) have urged ... cholera vaccines for future humanitarian use. "The ... stockpile of several million doses of cholera vaccine would ...
... Reporter , WEDNESDAY, Nov. 24 (HealthDay News) -- There,s encouraging ... babies. Children whose mothers took certain anti-seizure medications while breast-feeding ... 3, a new study finds. The multi-center study looked ... common antiepileptic drugs, and found no difference in IQ levels ...
Cached Medicine News:Health News:Parents of Bullies Urged to Open Lines of Communication 2Health News:A high BMI in childhood linked to greater heart disease risk in adolescence 2Health News:No Link Between Heartburn Drugs and Birth Defects: Study 2Health News:No Link Between Heartburn Drugs and Birth Defects: Study 3Health News:Experts urge US to create emergency cholera vaccine stockpile for humanitarian use 2Health News:Experts urge US to create emergency cholera vaccine stockpile for humanitarian use 3Health News:Experts urge US to create emergency cholera vaccine stockpile for humanitarian use 4Health News:Women Taking Certain Epilepsy Drugs Can Safely Breast-Feed, Study Suggests 2Health News:Women Taking Certain Epilepsy Drugs Can Safely Breast-Feed, Study Suggests 3
(Date:1/23/2015)... , Jan. 23, 2015 More than a third of ... of those with private insurance, filled a prescription for an ... report in this week,s Morbidity and Mortality Weekly Report (MMWR). ... providers to treat moderate to severe pain.  They are also ...
(Date:1/23/2015)...  HyGreen, Inc., a leader in hand hygiene monitoring, today ... a subsidiary of Ascendis Health Limited, in ... hundreds of millions of patients around the world are ... from patient to patient via the unwashed hands of ...
(Date:1/23/2015)... Cord Blood America, Inc. ( www.cordblood-america.com ) (OTC Bulletin Board: ... Preliminary Proxy Statement, Schedule 14A, with the U.S. Securities & ... for shareholders detailing why a "YES" vote to increase the ... As we reflect upon the 2014 fiscal year ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... Reportlinker.com announces that a new market research ... Innovations in Wound Care Devices and ... Introduction Wound ... range of sizes, shapes, stages, and types ...
... 2012 /PRNewswire-iReach/ -- Global Information, Inc. (GII) is ... Devices - Global Pipeline Analysis, Competitive Landscape and Market Forecasts ... The Insulin Delivery Devices Market is ... $11 Billion by 2017 GlobalData estimated ...
Cached Medicine Technology:Innovations in Wound Care Devices and Dressings 2Innovations in Wound Care Devices and Dressings 3Innovations in Wound Care Devices and Dressings 4Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 2Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 3Insulin Delivery Devices - Increasing Prevalence of Diabetes to Drive the Market 4
Reusable, stainless steel trephine with handle....
Each handle is designed to fit a specific trephine size....
Reusable, stainless steel trephine with handle....
Each handle is designed to fit a specific trephine size. For use in performing free-hand uniform donor buttons....
Medicine Products: