Navigation Links
Study Unveils New Insight To The Madness Of King George III

Researchers from Dana-Farber Cancer Institute had discovered a new molecular explanation for the episodic attacks of irrational and demented behavior in the disease called porphyria, the disease that was probably behind the // madness of king George III.

The Dana-Farber scientists say in a report featured on the cover of the August 26 issue of the journal Cell that the nutritional component of porphyria involves a key master metabolic molecule, PGC-1 alpha, in cells of the liver. The gene that makes PGC-1 alpha was isolated some time back.

King George III suffered from five prolonged, severe episodes of madness during his rule from 1760 to 1820. The symptoms recorded at the time sound to modern diagnosticians as typical of porphyria, though the King’s attacks were unusual in their severity and that they didn’t appear until he was 50.

Earlier this year, The Lancet had published a report saying that a test of strands of George III’s hair contained arsenic, which can provoke porphyria attacks.

PGC-1 alpha is a “transcriptional co activator” that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the “heating system” of brown fat cells that help prevent damage from cold in certain animals.

The researchers had found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver. Moreover, they had showed that hepatic PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria.

The findings suggest that patients with porphyria should avoid any drugs or foods that turn on PGC-1 alpha activity in the liver, the researchers say. There could be implications for treatment as well: high-carbohydrate diets aren’t a satisfactory therapy for affected patients as it make them gain, and fasting in order to lose the weight risks provoking attacks. Hopefully, the research ers say, it might be possible to develop more specific treatments now that the mechanism underlying the symptoms of porphyria is better understood.

Source: Newwise
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/21/2017)... ... , ... Providing for loved ones before one’s passing is of paramount importance. ... begin. “Now more than ever there are some questions that are far too critical ... said attorney Lisa Edgar Dickman, founder of the Law Offices of Lisa Edgar Dickman. ...
(Date:4/21/2017)... CA (PRWEB) , ... April 21, 2017 , ... ... to experienced, personalized dental care since 1985. After thirty-two years, Dr. Latner has become ... privilege to help my numerous clients over the years with all their dental needs,” ...
(Date:4/21/2017)... Miami, Fl (PRWEB) , ... April 21, 2017 , ... ... Earth Day is a day to clean, plant trees and look forward to a ... green isn’t just about doing something outdoors. Indoor air quality can be two to ...
(Date:4/21/2017)... ... April 21, 2017 , ... Federal ... five common elements between the Obamacare program that most Republicans love to hate ... Warfarin poison to kill hogs. , Like Obamacare, the Miller program centers ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... a significant bandwidth upgrade infrastructure service to Tele-Media Solutions. IFN is delivering ... of IFN’s consortium member-owners, Tele-Media Solution’s protect transport with 3GB Dual Access Internet ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  IRIDEX Corporation (Nasdaq: IRIX ... for the first quarter 2017 after the close of ... team will host a corresponding conference call beginning at ... Investors interested in listening to the conference call may ... or (703) 326-3030 for international callers, using conference ID: ...
(Date:4/19/2017)... , April 19, 2017  Sorrento Therapeutics, ... antibody-centric, clinical-stage biopharmaceutical company developing new treatments for ... the closing of its previously announced underwritten public ... at a public offering price of $2.00 per ... estimated offering expenses payable by Sorrento.  The net ...
(Date:4/18/2017)... 18, 2017  Cardinal Health (NYSE: CAH ... 2017 earnings per share (EPS) guidance and providing a ... in conjunction with this morning,s announcement of the planned ... Nutritional Insufficiency businesses. Cardinal Health now believes ... be at the bottom of its previous guidance range ...
Breaking Medicine Technology: