Navigation Links
Study Unveils New Insight To The Madness Of King George III

Researchers from Dana-Farber Cancer Institute had discovered a new molecular explanation for the episodic attacks of irrational and demented behavior in the disease called porphyria, the disease that was probably behind the // madness of king George III.

The Dana-Farber scientists say in a report featured on the cover of the August 26 issue of the journal Cell that the nutritional component of porphyria involves a key master metabolic molecule, PGC-1 alpha, in cells of the liver. The gene that makes PGC-1 alpha was isolated some time back.

King George III suffered from five prolonged, severe episodes of madness during his rule from 1760 to 1820. The symptoms recorded at the time sound to modern diagnosticians as typical of porphyria, though the King’s attacks were unusual in their severity and that they didn’t appear until he was 50.

Earlier this year, The Lancet had published a report saying that a test of strands of George III’s hair contained arsenic, which can provoke porphyria attacks.

PGC-1 alpha is a “transcriptional co activator” that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the “heating system” of brown fat cells that help prevent damage from cold in certain animals.

The researchers had found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver. Moreover, they had showed that hepatic PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria.

The findings suggest that patients with porphyria should avoid any drugs or foods that turn on PGC-1 alpha activity in the liver, the researchers say. There could be implications for treatment as well: high-carbohydrate diets aren’t a satisfactory therapy for affected patients as it make them gain, and fasting in order to lose the weight risks provoking attacks. Hopefully, the research ers say, it might be possible to develop more specific treatments now that the mechanism underlying the symptoms of porphyria is better understood.

Source: Newwise
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... , ... A product of digesting a micronutrient found in soy may hold ... soy foods, while others do not, a University of Pittsburgh Graduate School of Public ... made by some types of “good” gut bacteria when they metabolize isoflavones (micronutrients found ...
(Date:2/22/2017)... , ... February 22, 2017 , ... Pet obesity in ... 54% of dogs, according to the Association for Pet Obesity Prevention (APOP). During the ... pet food issues such as the benefits of corn and grains, value of raw ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... Safety, patient advocates stress that the patient context (age, illness and life choices) ... reasons to mitigate their occurrence. In addition, all too often, studies ...
(Date:2/21/2017)... Okla. (PRWEB) , ... February 21, 2017 , ... ... new Choctaw Nation Regional Medical Clinic in Durant, Oklahoma, on Feb. 21. , ... by clinic tours for community members, clinic employees, the construction team and tribal ...
(Date:2/21/2017)... ... ... Individuals who have been diagnosed with cancer are at ... management. Regular exercise in proper environments has been shown to benefit these patients, ... 23, 2017, 1:00-2:00 p.m. E.S.T., a dynamic HydroWorx webinar led by ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Conn. , Feb. 22, 2017   Protein ... maker of Flublok® Influenza Vaccine , announced today ... Partnership for Influenza Vaccine Introduction (PIVI) and the Mongolian ... devastating impacts of the flu.  The doses of Flublok ... Mongolia for health care workers, ...
(Date:2/22/2017)... , Feb. 22, 2017  Tri-Source Pharma announced ... efforts. A series of newly appointed positions were added ... and CEO, Robert DiCrisci , in the implementation ... and management of the recently consolidated subsidiary companies. ... executive team will be composed of the following eight ...
(Date:2/22/2017)... , February 22, 2017 ... Composite, the Dow Jones Industrial Average, and the ... Seven out of nine sectors ended Tuesday,s trading ... market sentiment, Stock-Callers.com assessed the following Medical Instruments ... Inc. (NASDAQ: TNDM), C. R. Bard Inc. (NYSE: ...
Breaking Medicine Technology: