Navigation Links
Study Unveils New Insight To The Madness Of King George III

Researchers from Dana-Farber Cancer Institute had discovered a new molecular explanation for the episodic attacks of irrational and demented behavior in the disease called porphyria, the disease that was probably behind the // madness of king George III.

The Dana-Farber scientists say in a report featured on the cover of the August 26 issue of the journal Cell that the nutritional component of porphyria involves a key master metabolic molecule, PGC-1 alpha, in cells of the liver. The gene that makes PGC-1 alpha was isolated some time back.

King George III suffered from five prolonged, severe episodes of madness during his rule from 1760 to 1820. The symptoms recorded at the time sound to modern diagnosticians as typical of porphyria, though the King’s attacks were unusual in their severity and that they didn’t appear until he was 50.

Earlier this year, The Lancet had published a report saying that a test of strands of George III’s hair contained arsenic, which can provoke porphyria attacks.

PGC-1 alpha is a “transcriptional co activator” that acts as an on-off switch for a number of genes involved in manufacture of glucose in the liver and in the “heating system” of brown fat cells that help prevent damage from cold in certain animals.

The researchers had found that PGC-1 alpha is an important factor controlling the expression of ALAS-1 in the fasted and fed liver. Moreover, they had showed that hepatic PCG-1 alpha is a major determinant of the severity of acute porphyric attacks in mouse models of chemical porphyria.

The findings suggest that patients with porphyria should avoid any drugs or foods that turn on PGC-1 alpha activity in the liver, the researchers say. There could be implications for treatment as well: high-carbohydrate diets aren’t a satisfactory therapy for affected patients as it make them gain, and fasting in order to lose the weight risks provoking attacks. Hopefully, the research ers say, it might be possible to develop more specific treatments now that the mechanism underlying the symptoms of porphyria is better understood.

Source: Newwise
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... January 16, 2017 , ... Permobil has just completed ... of custom seating systems has a well-earned reputation for premium quality, with a ... innovation and growth in the custom seating business, which enjoys strong demand, and ...
(Date:1/16/2017)... CA (PRWEB) , ... January 16, 2017 , ... ... manuscript in the Aesthetic Surgery Journal , the official journal of The ... conducted on lower eyelid retraction surgery. The procedure is designed to correct drooping, ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... NexTec Group ... a group of 100 organizations honored for their accomplishments in the field of midmarket ... growth, industry leadership and recognition, and innovation. Selection is not based on revenue and ...
(Date:1/15/2017)... ... January 15, 2017 , ... "On Tour is a music themed ... and ease," said Christina Austin - CEO of Pixel Film Studios. , On ... edit the style and animation of their slideshows. Place each slide on top of ...
(Date:1/14/2017)... ... 2017 , ... Healthy living brand Moody Zook recently came ... With more and more people opting to go organic in their lifestyle, the ... to specific needs. , Moody Zook focused particularly on their newly launched activated ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... 13, 2017  Alfalfa, cattle, leafy greens and rosy cheeked ... film , which emphasizes the food industry,s shift from response ... COPAN,s Swab Rinse Kit (SRK™) ... sampling process in the wake of the new FDA ... COPAN is expanding the U.S. production of the ...
(Date:1/13/2017)... 13, 2017 The 2016 election resulted ... several states voting in favor of legalizing cannabis for recreational ... market in the U.S. In addition, the state of ... annual cannabis products sales. The ArcView Group has published an ... legal cannabis sales in the U.S. last year reached $6.7 billion, ...
(Date:1/13/2017)... 2017 Research and Markets has announced the ... report to their offering. ... Cystic fibrosis (CF) is a progressive genetic condition ... fibroses transmembrane conductance regulator (CFTR) gene from both parents. The defective ... and result in the buildup of a thick and sticky mucus ...
Breaking Medicine Technology: