Navigation Links
Study Sheds Light on Value of Newer Antipsychotic Drugs for Schizophrenia

A study comparing medications for schizophrenia found two of three newer antipsychotic drugs are more effective in patients// who did not benefit from an older medication, according to a research.

The study is one of the latest stemming from the longstanding Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). Dr. Scott Stroup, associate professor of psychiatry in the UNC School of Medicine, is the lead author.

In the original CATIE study, 257 patients were initially selected randomly to take the older antipsychotic drug perphenazine. Of these, 192 discontinued the medication for various reasons, including ineffectiveness and intolerable side effects. Among those who discontinued, 114 agreed to be randomly chosen to take one of three newer antipsychotic medications – olanzapine, quetiapine or risperidone.

In the current study, Stroup and colleagues compared the effectiveness of the medications by determining how long patients stayed on their assigned medication. Those taking quetiapine stayed on the longest — averaging about 10 months before stopping. Those taking olanzapine discontinued after an average of about seven months, and those taking risperidone discontinued after an average of four months.

Although the discontinuation results suggest that olanzapine was generally on par with quetiapine, patients taking olanzapine had more weight- and metabolic-related side effects than those on the other medications. While none of those patients taking quetiapine discontinued use due to weight gain or metabolic side effects, 13 percent of those assigned to olanzapine discontinued it due to weight gain or metabolic problems and 5 percent of those on risperidone did so.

“The results favor quetiapine and, to an extent, olanzapine,” Stroup said. “These findings diverge somewhat from other CATIE studies in which second generation medications are compared, but overall there is consistency.”

Olanzapine is good at addressing symptoms but weight gain is problematic. Risperidone is a good choice overall but was not well tolerated by those who stopped perphenazine, presumably because of similarities in the two drugs, Stroup said.

“Quetiapine may have worked particularly well in the people who stopped perphenazine because these two drugs are fairly different from each other,” said Stroup. “These results remind us of the considerable variability in clinical circumstances and of our need to be responsive to an individual’s needs and preferences.”

Source-Newswse
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... ... February 27, 2017 , ... ... last week. In addition, Discount Power's RCE (Residential Customer Equivalent) count exceeds ... 2014. The company had 800 customers and 2,250 RCEs at the time of ...
(Date:2/27/2017)... ... February 27, 2017 , ... New Jersey ranks among the top five states ... And the need for advanced services is growing. , Project WE vs C ... in collaboration with their non-profit partners in their fight against cancer and in support ...
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home ... as Millbrae, Belmont, and Palo Alto, is proud to announce an important upgrade to ... consumers look for home care close to home, and by having city-specific pages, NuevaCare ...
(Date:2/26/2017)... ARLINGTON, VA (PRWEB) , ... February 26, 2017 , ... ... Medicaid Managed Care Summit, February 27-28 at the Sheraton Pentagon City Hotel in Arlington, ... work with PerformCARE to use behavioral health analytics to improve Medicaid population health management. ...
(Date:2/24/2017)... ... February 24, 2017 , ... HealthPostures, expert ... Core benefits and advantages built into the home office sit stand solution are ... feel. Ability to gain the benefits embedded in the TaskMate Go are available ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017  Interpace Diagnostics Group, ... provides clinically useful molecular diagnostic tests and pathology services, ... presented at the upcoming United States ... held March 4-10, 2017 in San Antonio, ... a review of data from the Company,s extensive experience ...
(Date:2/27/2017)... 27, 2017  International Biophysics Corporation, a global medical device ... announced a 34% revenue growth in 2016 when compared to ... sales.  This growth was fueled by its AffloVest® sales in ... the expansion of its global sales of surgical product lines. ... "As we enter our 25 th year in delivering ...
(Date:2/27/2017)... PLACENTIA, Calif. , Feb. 27, 2017   ... new line of nutritional supplements using its groundbreaking new ... and 90 percent of potency through digestion per ... nutritional supplements solve the problem of nutritional waste and ... Prevent degradation during digestive processes Improve ...
Breaking Medicine Technology: