Navigation Links
Study Sheds Light on Value of Newer Antipsychotic Drugs for Schizophrenia

A study comparing medications for schizophrenia found two of three newer antipsychotic drugs are more effective in patients// who did not benefit from an older medication, according to a research.

The study is one of the latest stemming from the longstanding Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE). Dr. Scott Stroup, associate professor of psychiatry in the UNC School of Medicine, is the lead author.

In the original CATIE study, 257 patients were initially selected randomly to take the older antipsychotic drug perphenazine. Of these, 192 discontinued the medication for various reasons, including ineffectiveness and intolerable side effects. Among those who discontinued, 114 agreed to be randomly chosen to take one of three newer antipsychotic medications – olanzapine, quetiapine or risperidone.

In the current study, Stroup and colleagues compared the effectiveness of the medications by determining how long patients stayed on their assigned medication. Those taking quetiapine stayed on the longest — averaging about 10 months before stopping. Those taking olanzapine discontinued after an average of about seven months, and those taking risperidone discontinued after an average of four months.

Although the discontinuation results suggest that olanzapine was generally on par with quetiapine, patients taking olanzapine had more weight- and metabolic-related side effects than those on the other medications. While none of those patients taking quetiapine discontinued use due to weight gain or metabolic side effects, 13 percent of those assigned to olanzapine discontinued it due to weight gain or metabolic problems and 5 percent of those on risperidone did so.

“The results favor quetiapine and, to an extent, olanzapine,” Stroup said. “These findings diverge somewhat from other CATIE studies in which second generation medications are compared, but overall there is consistency.”

Olanzapine is good at addressing symptoms but weight gain is problematic. Risperidone is a good choice overall but was not well tolerated by those who stopped perphenazine, presumably because of similarities in the two drugs, Stroup said.

“Quetiapine may have worked particularly well in the people who stopped perphenazine because these two drugs are fairly different from each other,” said Stroup. “These results remind us of the considerable variability in clinical circumstances and of our need to be responsive to an individual’s needs and preferences.”


Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:

(Date:11/30/2015)... Caicos Islands, BWI (PRWEB) , ... December 01, 2015 , ... ... Recently Caribbean Journal, one of the leading digital news sites highlighting Caribbean destinations, ... reason? The weather. While much of North America shivers under chilly grey skies ...
(Date:11/30/2015)... ... 01, 2015 , ... Live Very Well is excited to ... on . The multi-carrier insurance exchange platform offers individual vision and ... to compare, quote and match plans to meet their needs. , Beginning ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... ... November 30, 2015 , ... The world of hair transplants and restoration ... extraction. These techniques and procedures have been in use for many years and are ... Dr. Parsa Mohebi, M.D. has utilized many of these methods over the years, he ...
(Date:11/30/2015)... ... 30, 2015 , ... During the week of Thanksgiving, the ... for its research, education, support, and advocacy efforts. The campaign is held every ... Mesothelioma Applied Research Foundation, which also goes by Meso Foundation, holds the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015 MEDTEC Japan 2016, Asia,s ... is to be held in Tokyo from 20 th  - 22 nd April ... --> -->   --> --> ... the United States . With the aging population and the government ... grow steadily. --> the United States . With the ...
(Date:11/30/2015)... 30, 2015 Diplomat Pharmacy, Inc. (NYSE: ... the Detroit Free Press as a Top Workplace , ... to work for in 2015. ... 100 winners annually, based on employee surveys rating company leadership, ... Workplaces are based solely on employee feedback. The survey is ...
(Date:11/30/2015)...  IBA Molecular North America, Inc. (IBAMNA), a U.S. ... that as of January 1, 2016, it will do ... to rebrand the company reflects a refined vision for ... close relationship with Zevacor Molecular.  Both IBAMNA and Zevacor ... Peter Burke , Vice President Sales ...
Breaking Medicine Technology: