Navigation Links
Study Reveals Little-known Cell Networks Vital to Circadian Rhythm

Circadian rhythm is the basic 24-hour cycle that involves various behaviors, including sleeping and eating, in all living organisms. In mammals, the circadian clock is organized hierarchically in a series of multiple oscillators. At the top of this hierarchy, the suprachiasmatic nucleus (SCN), a region of the brain that is the body"s main rhythmic regulator, integrates light information from the eyes and coordinates peripheral oscillators throughout the body.

By examining effects of genetic mutations at the level of single cells and tissues, the study showed that intercellular mechanisms are in fact essential to the operation of cellular circadian clocks.

"Our study reveals some previously overlooked mechanisms for sustaining cellular circadian rhythm," said Steve A. Kay, whose laboratory spearheaded the research. "Essentially, when cells communicate en masse through these highly networked electrical or neurochemical interactions, the system responds far more effectively."

The SCN intercellular network, Kay said, is necessary not only to stabilize oscillators in the peripheral tissues but also to provide a robust response to various genetic mutations. In fact, the network interactions unique to the SCN can compensate for some genetic defects in the Period (Per) and Cryptochrome (Cry) genes-the clock genes-to preserve circadian rhythm. In fact, the circadian defects observed in mutant oscillators were clearly more extreme when measured at the tissue and cell levels than demonstrated by behavioral observations.

"Because single cells are ordinarily capable of functioning as autonomous oscillators," Kay noted, "our previous understanding of clock mechanisms has rested precariously on the idea that if we studied behavior, we could assume that same thing was happening at the single cell level. Our study shows that's not the case."

The lack of networked interactions in peripheral tissues may actually be an adaptive feature in most circumstances. SCN cells in vivo must synchronize not only to light-dark cycles but also to one another to coordinate circadian behavior. Lack of coupling may allow peripheral oscillators to anticipate and respond rapidly not only to the synchronizing cues emanating from the SCN but also to physiological signals related to feeding and behavior.

"Future studies should focus on addressing the system impact of these cellular networks," Kay said. "Our results validate clock model predictions previously overlooked or sometimes regarded as model flaws. Newer models are needed to accommodate the novel cell-autonomous phenotypes we uncovered."


Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:

(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015 ... of the company’s growing product line of food safety and seafood fraud prevention ... (Oncorhynchus nerka) – allow InstantLabs to offer fast, reliable species identification for the ...
(Date:12/1/2015)... York, NY (PRWEB) , ... December 01, 2015 ... ... of non-traumatic limb amputations in the United States. Podiatrists are well aware that ... to adopt therapeutic behaviors) are often catastrophic contributors to diseases of the diabetic ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... Center of Excellence (BHCOE) today announced that the organization has awarded Education and ... Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers that ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... Effective Post-Affiliation Integration ,” addresses a main “pain point” for merging or aligning ... results, once a deal is signed. This quick-read guidance suggests that failing ...
(Date:12/1/2015)... Beverly Hills, CA (PRWEB) , ... December 01, ... ... honored by Modern Luxury’s Angeleno Magazine as a Modern Man for 2015. ... luxury lifestyle publisher in the United States. Established in 1994, Modern Luxury includes ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... and PITTSBURGH , Dec. ... announced that it expects to be the first to ... funded by international donors, TLE400 (Tenofovir Disoproxyl Fumarate 300 ... for $99 per patient, per year. Mylan partnered with ... The significantly reduced price could generate savings of tens ...
(Date:12/1/2015)... Dec. 1, 2015  Six months of adjunctive metformin therapy ... 1 diabetes, according to new research from T1D Exchange ... may have a beneficial effect on measures of obesity, including ... of the Journal of the American Medical Association , ... effect of metformin on overweight and obese adolescents with type ...
(Date:12/1/2015)... 2015 ... of the "2016 Europe Enteric ... Coli, Enterovirus, Rhinovirus, Rotavirus, Salmonella, Shigella, ... offering. --> ) ... "2016 Europe Enteric Disease Testing ...
Breaking Medicine Technology: