Navigation Links
Study Reveals Little-known Cell Networks Vital to Circadian Rhythm

Circadian rhythm is the basic 24-hour cycle that involves various behaviors, including sleeping and eating, in all living organisms. In mammals, the circadian clock is organized hierarchically in a series of multiple oscillators. At the top of this hierarchy, the suprachiasmatic nucleus (SCN), a region of the brain that is the body"s main rhythmic regulator, integrates light information from the eyes and coordinates peripheral oscillators throughout the body.

By examining effects of genetic mutations at the level of single cells and tissues, the study showed that intercellular mechanisms are in fact essential to the operation of cellular circadian clocks.

"Our study reveals some previously overlooked mechanisms for sustaining cellular circadian rhythm," said Steve A. Kay, whose laboratory spearheaded the research. "Essentially, when cells communicate en masse through these highly networked electrical or neurochemical interactions, the system responds far more effectively."

The SCN intercellular network, Kay said, is necessary not only to stabilize oscillators in the peripheral tissues but also to provide a robust response to various genetic mutations. In fact, the network interactions unique to the SCN can compensate for some genetic defects in the Period (Per) and Cryptochrome (Cry) genes-the clock genes-to preserve circadian rhythm. In fact, the circadian defects observed in mutant oscillators were clearly more extreme when measured at the tissue and cell levels than demonstrated by behavioral observations.

"Because single cells are ordinarily capable of functioning as autonomous oscillators," Kay noted, "our previous understanding of clock mechanisms has rested precariously on the idea that if we studied behavior, we could assume that same thing was happening at the single cell level. Our study shows that's not the case."

The lack of networked interactions in peripheral tissues may actually be an adaptive feature in most circumstances. SCN cells in vivo must synchronize not only to light-dark cycles but also to one another to coordinate circadian behavior. Lack of coupling may allow peripheral oscillators to anticipate and respond rapidly not only to the synchronizing cues emanating from the SCN but also to physiological signals related to feeding and behavior.

"Future studies should focus on addressing the system impact of these cellular networks," Kay said. "Our results validate clock model predictions previously overlooked or sometimes regarded as model flaws. Newer models are needed to accommodate the novel cell-autonomous phenotypes we uncovered."


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and ... Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD ... that can be easily incorporated into liquid products, while reducing costs to end users. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... 12, 2017   EcoVadis , the leading platform for environmental, social ... annual edition of its Global CSR Risk and Performance Index. The report ... based on Scorecard Ratings that analyzed nearly 800,000 data points across the ... ... ...
(Date:9/12/2017)...  ValGenesis Inc., the global leader in Enterprise ... announce the appointment of Dr. Ajaz Hussain ... Directors and Chairman of Advisory Board beginning September ... to manage their entire validation lifecycle process electronically ... process. Furthermore, ValGenesis VLMS enables rigorous compliance, helps ...
Breaking Medicine Technology: