Navigation Links
Study Identifies Mechanism Which May Help Tamoxifen Work Better

The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows.

“Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch signal,” said senior study investigator Dr. Lucio Miele, professor, departments of pathology, pharmacology and experimental therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. “This helps the cancer cells survive the loss of estrogen.

“Blocking the Notch pathway with a Notch inhibitor offers a new strategy to stopping breast cancer,” said Miele, director, breast cancer basic science program, Cardinal Bernardin Cancer Center, Loyola University Health System. He presented the findings here today at the 29th annual San Antonio Breast Cancer Symposium.

Notch inhibitors are currently in early human clinical trials.

“Results of our study shows that in estrogen receptor positive cancers, a drug which inhibits the Notch protein should be used in combination with estrogen inhibitors,” said Miele. “In estrogen receptor negative cancers, the Notch inhibitor can be used alone or with chemotherapy.”

A significant number of people currently become resistant to the breast cancer drug tamoxifen. “For tamoxifen to work better, you need to inhibit the Notch pathway,” said co-author Dr. Kathy S. Albain, professor, division of hematology/oncology, department of medicine, Loyola University Chicago Stritch School of Medicine.

“This can be done by using a novel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor,” said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola University Health System, Maywood, Ill.


'"/>




Page: 1 2

Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Identifies Mechanism Which May Help Tamoxifen Work Better

(Date:9/20/2014)... York, New York (PRWEB) September 20, 2014 ... filings continue to grow in federal court, Bernstein ... Food & Drug Administration (FDA) have voted overwhelmingly ... low testosterone in men be subjected to further ... According to a report published on September 18th ...
(Date:9/20/2014)... 19, 2014 (HealthDay News) -- The avian flu that ... could be spread through respiratory drops and therefore poses ... study. Although no human illnesses have been linked ... Children,s Research hospital have discovered natural mutations to the ... travel through the air in droplets. Current seasonal ...
(Date:9/20/2014)... September 20, 2014 Ticket Down ... concert tickets for her 2015 “Honeymoon Tour.” This well-known ... for added savings. , In early 2015, fans will have ... the world across North America. Twenty-one-year-old Ariana Grande will hit ... will take her to 25 cities across the United States ...
(Date:9/20/2014)... September 20, 2014 iFitDress.com, the popular ... for women, has recently unveiled its new collection of ... sale for special offer on these new outfits; it ... season. All customers can now buy cheap cocktail ... company’s sales representative says, “We have extensive experience in ...
(Date:9/20/2014)... have advised their patients against drinking coffee and wine. Dr. ... advice and changing his stance after considering two recent studies ... health. “There’s good news and great news,” says Dr. Wells, ... against gum disease, and red wine can help fight cavities!” ... September 2014 issue of Boston University School of Medicine ...
Breaking Medicine News(10 mins):Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Avian Flu In Harbor Seals Could Infect People 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:Fashionable Cocktail Dresses Unveiled Online at iFitDress.com 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3
... HealthDay Reporter , TUESDAY, March 6 (HealthDay News) -- ... have significantly less asthma and allergies than Swiss children who ... What,s more, the Amish youngsters even have less ... up on non-Amish farms. The study could support ...
... TUESDAY, March 6 (HealthDay News) -- A smoking ban ... underweight babies, a new study finds. The nationwide ban ... The researchers analyzed data on preterm delivery and small-for-gestational-age babies ... of mothers who smoked dropped from more than 25 percent ...
... , TUESDAY, March 6 (HealthDay News) -- Vitamin D deficiency ... with an increased risk of death, a new study finds. ... vitamin D deficiency, according to lead author Dr. Stefan Pilz, ... Their study of nearly 1,000 female nursing home residents, ...
... patients in the United States remain in care consistently, according ... the University of Pennsylvania published online this week in ... is the first to provide a comprehensive national estimate of ... most likely to continue their treatment over time. "Helping ...
... March 6, 2012 Dr. Eric Olson ... UT Southwestern Medical Center, has won the 2012 Passano ... development of the heart and other muscles. In ... that Dr. Olson,s discoveries at the interface of developmental ...
... York, NY (March 5, 2012) Today, the ... Accelerating Cancer Cures Research Symposium, focused on rebuilding ... laboratory discoveries into new cancer therapies. The event, ... scientists and other leading pharmaceutical companies, including Eli ...
Cached Medicine News:Health News:Amish Farm Kids Have Lower Asthma, Allergy Risk: Study 2Health News:Amish Farm Kids Have Lower Asthma, Allergy Risk: Study 3Health News:Amish Farm Kids Have Lower Asthma, Allergy Risk: Study 4Health News:Lack of Vitamin D May Harm Older Women's Health 2Health News:1 in 4 US HIV patients don't stay in care, Penn study shows 2Health News:1 in 4 US HIV patients don't stay in care, Penn study shows 3Health News:Olson, noted UT Southwestern molecular biologist, wins 2012 Passano Award 2Health News:Olson, noted UT Southwestern molecular biologist, wins 2012 Passano Award 3Health News:Industry leaders join together for historic Accelerating Cancer Cures Research Symposium 2
(Date:9/19/2014)... Sept. 19, 2014 Today, iHealth Lab Inc. announced ... Ventures, Ltd. for its first institutional round of funding. ... iHealth,s global reach, accelerate growth and innovation, and invest ... the investment, Xiaomi Ventures will join iHealth,s board of ... infrastructure and ecommerce. "We are very pleased ...
(Date:9/19/2014)... According to the new ... therapy, Hydrotherapy), Accessories (Posture Mirror, Exercise Ball), Applications (Pediatric, ... Global Forecast to 2019" published by MarketsandMarkets, the global ... Million by 2019 from $14,240.0 Million in 2014, ... 2019. Browse 74 market data tables ...
(Date:9/19/2014)... , Sept. 19, 2014 The American ... Drive Medical Design and Manufacturing has joined the AAHomecare ... CEO Harvey Diamond have been actively involved ... history, as it has quickly grown into a major ... partners like Drive allows AAHomecare to increase efforts on ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2
Fortitude as a unique complement to the spinal concepts family of products....
As a unique complement to the spinal concepts family of products....
... is two system in one. Uncomplicated ... all cervicle spine retraction objectives. Quick-connect ... soft tissue retraction and enhanced visualization. ... with minimal interference. Two retractor bodies, ...
Codman cervical retractor, large, with set of seven sharp blades....
Medicine Products: