Navigation Links
Study Identifies Mechanism Which May Help Tamoxifen Work Better

The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows.

“Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch signal,” said senior study investigator Dr. Lucio Miele, professor, departments of pathology, pharmacology and experimental therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. “This helps the cancer cells survive the loss of estrogen.

“Blocking the Notch pathway with a Notch inhibitor offers a new strategy to stopping breast cancer,” said Miele, director, breast cancer basic science program, Cardinal Bernardin Cancer Center, Loyola University Health System. He presented the findings here today at the 29th annual San Antonio Breast Cancer Symposium.

Notch inhibitors are currently in early human clinical trials.

“Results of our study shows that in estrogen receptor positive cancers, a drug which inhibits the Notch protein should be used in combination with estrogen inhibitors,” said Miele. “In estrogen receptor negative cancers, the Notch inhibitor can be used alone or with chemotherapy.”

A significant number of people currently become resistant to the breast cancer drug tamoxifen. “For tamoxifen to work better, you need to inhibit the Notch pathway,” said co-author Dr. Kathy S. Albain, professor, division of hematology/oncology, department of medicine, Loyola University Chicago Stritch School of Medicine.

“This can be done by using a novel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor,” said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola University Health System, Maywood, Ill.

Albain also said this research suggests new therapeutic strategies for women with breast cancer.

Source-Nwswise
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... ... 2016 , ... Just in time for the holiday season, the celebrated paleo ... for Honeyville’s new Organic Quinoa Flour product for sale at Costco stores throughout the ... , “I think it’s wonderful that a growing number of retailers such as ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... SevenPoint2 released the much-anticipated HydroFX for Water®. This first-of-its-kind water-soluble powder supplement ... of the world’s most powerful antioxidants, molecular hydrogen, HydroFX for Water transforms ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... of a powerful woman's story of sacrifice and enlightenment. , “Tatiana ... author, Carolyn Fryer. Always looking for creative outlets, Carolyn gravitated toward writing through ...
(Date:12/6/2016)... ... December 06, 2016 , ... The OSHA Training Center ... Education Center headquartered in Northern California, has announced the addition of a Public ... health training to public sector employees. , “The primary goal of the Public ...
(Date:12/5/2016)... ... 05, 2016 , ... What: Shriners Hospitals for Children, with the help of ... – using a video monitor and web-enabled camera. Santa visits with children through Dimension ... a Christmas Wonderland, which is where the video connection to the North Pole will ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Nov. 29, 2016 Several leading ... by Accera, Inc. at 11 a.m. EST ... International Conference on Clinical Trials for Alzheimer,s Disease (CTAD). ... metabolism in Alzheimer,s disease and therapeutic targets that address ... "Following the recent failure of another therapy targeting ...
(Date:12/5/2016)... DUBLIN , Dec 5, 2016 ... Blotting Market by Product (Instruments, Consumables), Application (Biomedical & Biochemical Research, ... Companies) - Global Forecasts to 2021" report to their offering. ... , , ... reach USD 730.7 Million in 2021 from USD 574.8 Million in ...
(Date:12/5/2016)... and PUNE, India , December 5, 2016 /PRNewswire/ ... titled, "Surgical Sutures Market by Product Type and by Application - Global Opportunity ... for $3,360 million in 2015, and is expected to reach $5,255 million by ... segment dominated the market in 2015 with more than four-fifths share. ... ...
Breaking Medicine Technology: