Navigation Links
Study Identifies Mechanism Which May Help Tamoxifen Work Better

The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows.

“Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch signal,” said senior study investigator Dr. Lucio Miele, professor, departments of pathology, pharmacology and experimental therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. “This helps the cancer cells survive the loss of estrogen.

“Blocking the Notch pathway with a Notch inhibitor offers a new strategy to stopping breast cancer,” said Miele, director, breast cancer basic science program, Cardinal Bernardin Cancer Center, Loyola University Health System. He presented the findings here today at the 29th annual San Antonio Breast Cancer Symposium.

Notch inhibitors are currently in early human clinical trials.

“Results of our study shows that in estrogen receptor positive cancers, a drug which inhibits the Notch protein should be used in combination with estrogen inhibitors,” said Miele. “In estrogen receptor negative cancers, the Notch inhibitor can be used alone or with chemotherapy.”

A significant number of people currently become resistant to the breast cancer drug tamoxifen. “For tamoxifen to work better, you need to inhibit the Notch pathway,” said co-author Dr. Kathy S. Albain, professor, division of hematology/oncology, department of medicine, Loyola University Chicago Stritch School of Medicine.

“This can be done by using a novel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor,” said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola University Health System, Maywood, Ill.

Albain also said this research suggests new therapeutic strategies for women with breast cancer.

Source-Nwswise
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2017)... & Caicos Islands, BWI (PRWEB) , ... September 25, 2017 , ... ... to announce the resort is re-opening on October 1st. And, throughout the month ... three bedroom oceanfront rentals. , Hurricane Irma and Maria have passed and damage ...
(Date:9/24/2017)... ... ... Messiah 8 with the 3rd Anti Christ”: a forceful and dynamic narrative that ... Anti Christ” is the creation of published author, Albert Velazquez. , “It ... Velazquez states, “I always come to the same conclusion: God loves working in mysterious ...
(Date:9/23/2017)... ... September 23, 2017 , ... A ... fighting obesity of Robert Kushner, director of Chicago’s Center for Lifestyle Medicine at ... healthier habits, the article notes that the center routinely recommends weight loss surgeries ...
(Date:9/22/2017)... ... September 22, 2017 , ... On Sunday, September 24, hundreds will ... Olympian, Florence Joyner, still considered the fastest woman of all time. Flo Jo ... Mary Joyner, will sing the National Anthem. Mary was a contestant on the ...
(Date:9/22/2017)... ... September 22, 2017 , ... After a long health ... a new lease on life with assistance from CreditAssociates. CreditAssociates provides debt relief ... with unsecured debt. The senior is one of the satisfied clients who expressed ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... 2017  Xyntek Inc. has announced another milestone in their continued growth and ... meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams Street, Suite 1528, ... Xyntek's recently ... ...
(Date:9/5/2017)... 2017  Just 18 months after its February 2016 ... announce the appointment of three new senior people to ... Dominic Jones-Phillips and James Wright bring ... Tammy Wynne joins as ... writers. She has over ten years, experience in global ...
(Date:9/1/2017)... , Sept. 1, 2017 Michael Penna ... Inc , highlights opportunities for growth in his response ... that Marlin Equity is seeking a buyer for eMDs. ... award-winning 22-year-old healthcare solutions Value Added Reseller and national ... "As the healthcare market continues ...
Breaking Medicine Technology: