Navigation Links
Study Identifies Mechanism Which May Help Tamoxifen Work Better

The “crosstalk” between estrogen and a special protein responsible for cell development (Notch) helps breast cancer cells// proliferate and spread, a new study shows.

“Breast cancer cells respond to loss of estrogen, which is caused by commonly used hormonal therapy, by increasing the Notch signal,” said senior study investigator Dr. Lucio Miele, professor, departments of pathology, pharmacology and experimental therapeutics, Loyola University Chicago Stritch School of Medicine, Maywood, Ill. “This helps the cancer cells survive the loss of estrogen.

“Blocking the Notch pathway with a Notch inhibitor offers a new strategy to stopping breast cancer,” said Miele, director, breast cancer basic science program, Cardinal Bernardin Cancer Center, Loyola University Health System. He presented the findings here today at the 29th annual San Antonio Breast Cancer Symposium.

Notch inhibitors are currently in early human clinical trials.

“Results of our study shows that in estrogen receptor positive cancers, a drug which inhibits the Notch protein should be used in combination with estrogen inhibitors,” said Miele. “In estrogen receptor negative cancers, the Notch inhibitor can be used alone or with chemotherapy.”

A significant number of people currently become resistant to the breast cancer drug tamoxifen. “For tamoxifen to work better, you need to inhibit the Notch pathway,” said co-author Dr. Kathy S. Albain, professor, division of hematology/oncology, department of medicine, Loyola University Chicago Stritch School of Medicine.

“This can be done by using a novel drug to block the Notch pathway while simultaneously controlling estrogen signaling through the estrogen receptor,” said Albain, director, thoracic oncology clinical research program; director, breast clinical research program; and co-director, multidisciplinary breast oncology center; Loyola University Health System, Maywood, Ill.

Albain also said this research suggests new therapeutic strategies for women with breast cancer.

Source-Nwswise
SRM
'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... 2017 , ... The American College of Medical Informatics (ACMI) will present the ... Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium ... a pioneer in the field of medical informatics, this prestigious award is presented to ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)... , Oct. 4, 2017  According to the Centers for Disease Control ... of October . PhysicianOne Urgent Care is helping communities across ... NY , by offering no-cost* flu shots through the end of ... by certain health insurance regulations. ... best time to get a flu shot is by the end of ...
Breaking Medicine Technology: