Navigation Links
Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss

Researchers have now identified a signaling pathway in the brain, which has been found a crucial role in regulating food intake. Furthermore, this pathway linked to the development of diabetes //and cancer could pave way for novel weight loss methods in obese individuals.

Scientists from UC's Genome Research Institute demonstrated that the signaling pathway mTOR--activated by nutrient and hormonal signals--plays a role in the brain's ability to sense how much energy the body has available.

This finding, the researchers say, suggests that very specific micronutrients may drive these pathways in the brain and could lead to a more scientific approach to diet design to help regulate body weight.

The study, led by Randy Seeley, PhD, professor in UC's psychiatry department, appears in the May 12, 2006 issue of the journal Science.

Ingesting calories (energy in the form of nutrients) has two purposes, says Dr. Seeley.

‘We take in calories to maintain levels of stored fuel (energy) and adequate available fuel,’ he says. ‘The signals that tell our brain about both the stored and the available energy in our body can activate the mTOR pathway in key parts of the brain that control appetite.’

Knowing that mTOR basically serves as a ‘check-point’ for sensing energy changes, the researchers predicted that it could be manipulated to alter food intake.

The mTOR pathway is very sensitive to ‘branched-chain’ amino acids, particularly leucine, Dr. Seeley explains. In laboratory studies, he and his team found that when they administered leucine directly to the hypothalamus, a brain region that controls a number of metabolic processes, animals ate less.

Other, similar amino acids did not give the same results.

This animal study, says Dr. Seeley, could eventually have implications for human obesity.

‘Rather than basing our diets only on macronutrients like fat or carboh ydrates, we might one day be designing diets based on micronutrients like amino acids,’ he says.

But, Dr. Seeley adds, that certainly doesn't mean people should ‘run out and add more leucine to their diets.’

‘We still have a lot to learn about how these nutrients would act if simply ingested with other nutrients, in what form they could be most effective, and even if they are effective at all when not administered directly to the brain,’ he sas.


'"/>




Related medicine news :

1. Tomato Sauce reduces Cancer Risk- Study
2. Study on obesity and heart failure
3. National Lung Study in the process
4. Study casts doubt on keyboard ills
5. Study reveals how stress can make you sick
6. Study reveals how stress can make you sick
7. Study supports vegetable diet
8. Study to look at early surgery to treat epilepsy
9. Its Never Too Late to Stop Smoking,Study Finds
10. New Technique to Study Infants Brain.
11. Groundbreaking Study Gives Hope For Patients With Kidney Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... 24, 2017 , ... The California State University Institute for Palliative Care ... or interested in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: ... San Diego on Sept. 28 and 29, 2017, on the campus of California State ...
(Date:2/24/2017)... ... ... Indiana Fiber Network (IFN) President and CEO Kelly C. Dyer recently announced that ... Chairman of the Management Committee when IFN was originally formed in 2002 where he ... and development of the business plan. He became the first paid employee of ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head ... division on February 12th. Ms. Esparza qualified into this prestigious status after ... held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... jointly issued a letter to withdraw previous guidance issued by the ... identity. The guidance issued in May 2016 by the Obama Administration came in ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease Report®, ... be participating in Rare Disease Day events, hosted by the Rare Disease Legislative ... Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews with ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  MiMedx Group, Inc. (NASDAQ: MDXG), the leading regenerative ... to develop and market advanced products and therapies for ... and Dental sectors of healthcare, today announced its record ... December 31, 2016. Full Year 2016 Highlights ... increase over full year 2015 revenue ...
(Date:2/23/2017)... On Wednesday, February 22, 2017, US markets saw ... sectors finished the trading sessions in green, four closed in ... indices were also mixed at the close of yesterday,s session. ... by 0.09%; the Dow Jones Industrial Average edged 0.16% higher, ... 2,362.82, down 0.11%. This Thursday morning, Stock-Callers.com looks at the ...
(Date:2/23/2017)... 2017 Tillotts Pharma is strengthening ... Berlin office was opened in January 2017 ... portfolio includes Entocort ® for the treatment of ... ulcerative colitis, and VistaPrep ® for bowel preparation ... pharmaceutical company focused on the treatment of gastrointestinal (GI) ...
Breaking Medicine Technology: